Detailed information NTG0195381

Bioinformatically predicted

Overview

• Name: comYC
• Type: Machinery gene
• Locus tag: A7J08_RS00900
• Genome accession: NZ_CP017088
• Coordinates: 146999..147280 (+)
• Length: 93 a.a.
• NCBI ID: WP_053866667.1
• Uniprot ID: A0A3Q8BIE2
• Organism: Streptococcus suis strain SRD478
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 141999..152280

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A7J08_RS00880 (A7J08_00875)	-	143507..143881 (+)	375	WP_024385120.1	DUF1033 family protein	-
A7J08_RS00885 (A7J08_00880)	-	143915..144826 (-)	912	Protein_136	S66 peptidase family protein	-
A7J08_RS00890 (A7J08_00885)	comYA	145098..146048 (+)	951	WP_053867353.1	competence type IV pilus ATPase ComGA	Machinery gene
A7J08_RS00895 (A7J08_00890)	comYB	145960..146997 (+)	1038	WP_238600014.1	competence type IV pilus assembly protein ComGB	Machinery gene
A7J08_RS00900 (A7J08_00895)	comYC	146999..147280 (+)	282	WP_053866667.1	competence type IV pilus major pilin ComGC	Machinery gene
A7J08_RS00905 (A7J08_00900)	comGD	147261..147668 (+)	408	WP_053866668.1	competence type IV pilus minor pilin ComGD	-
A7J08_RS00910 (A7J08_00905)	comYE	147640..147933 (+)	294	WP_053866669.1	competence type IV pilus minor pilin ComGE	Machinery gene
A7J08_RS00915 (A7J08_00910)	comGF/cglF	147920..148354 (+)	435	WP_053866670.1	competence type IV pilus minor pilin ComGF	Machinery gene
A7J08_RS00920 (A7J08_00915)	comGG	148332..148745 (+)	414	WP_053866671.1	competence type IV pilus minor pilin ComGG	-
A7J08_RS00925 (A7J08_00920)	comYH	148795..149748 (+)	954	WP_053866672.1	class I SAM-dependent methyltransferase	Machinery gene
A7J08_RS00930 (A7J08_00925)	-	149798..150985 (+)	1188	WP_053866673.1	acetate kinase	-
A7J08_RS00940 (A7J08_00930)	-	151299..151850 (+)	552	WP_053866674.1	folate family ECF transporter S component	-

Sequence

Protein

• Length: 93 a.a.
• Molecular weight: 10390.31 Da
• Isoelectric Point: 7.0116

>NTDB_id=195381 A7J08_RS00900 WP_053866667.1 146999..147280(+) (comYC) [Streptococcus suis strain SRD478]
MKKLIEVKVKGFTLVEMLVVLGIISLLLLLFVPNLSQQKDVVQKKGNAAVVKVVESQMELYELEHDTEATVAELQAKGYI
TEKQAEQYATAKK

Nucleotide

• Length: 282 bp

>NTDB_id=195381 A7J08_RS00900 WP_053866667.1 146999..147280(+) (comYC) [Streptococcus suis strain SRD478]
ATGAAAAAGTTAATTGAAGTGAAGGTAAAAGGGTTCACTCTGGTGGAAATGTTAGTCGTTTTGGGAATTATTAGCCTGCT
CTTGCTCCTTTTTGTGCCAAATTTGAGCCAGCAGAAGGATGTTGTTCAGAAGAAGGGGAATGCGGCAGTTGTCAAAGTAG
TGGAGAGTCAAATGGAGCTCTATGAATTGGAACATGACACGGAAGCAACGGTGGCAGAGTTGCAGGCGAAAGGCTATATT
ACTGAAAAACAAGCGGAGCAGTATGCTACGGCGAAAAAATAA

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (8-30)

3D structure

• AlphaFold DB: A0A3Q8BIE2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYC	Streptococcus suis isolate S10	91.398	100	0.914
comGC/cglC	Streptococcus pneumoniae TIGR4	63.043	98.925	0.624
comGC/cglC	Streptococcus pneumoniae Rx1	63.043	98.925	0.624
comGC/cglC	Streptococcus pneumoniae D39	63.043	98.925	0.624
comGC/cglC	Streptococcus pneumoniae R6	63.043	98.925	0.624
comGC/cglC	Streptococcus mitis NCTC 12261	63.043	98.925	0.624
comGC/cglC	Streptococcus mitis SK321	63.043	98.925	0.624
comYC	Streptococcus gordonii str. Challis substr. CH1	62.921	95.699	0.602
comYC	Streptococcus mutans UA140	62.5	94.624	0.591
comYC	Streptococcus mutans UA159	62.5	94.624	0.591
comGC	Lactococcus lactis subsp. cremoris KW2	59.091	94.624	0.559
comGC	Staphylococcus aureus MW2	47.436	83.871	0.398
comGC	Staphylococcus aureus N315	47.436	83.871	0.398
comGC	Bacillus subtilis subsp. subtilis str. 168	47.222	77.419	0.366