Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   DQL01_RS10635 Genome accession   NZ_LS483451
Coordinates   1972596..1973537 (-) Length   313 a.a.
NCBI ID   WP_000249571.1    Uniprot ID   A0A0B7M3Q7
Organism   Streptococcus pneumoniae strain 4041STDY6836166     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1967596..1978537
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL01_RS10595 comYH 1968082..1969035 (-) 954 WP_000345119.1 class I SAM-dependent methyltransferase Machinery gene
  DQL01_RS10600 - 1969096..1969690 (-) 595 Protein_1996 class I SAM-dependent methyltransferase -
  DQL01_RS10605 comGG/cglG 1969827..1970240 (-) 414 WP_050114148.1 competence type IV pilus minor pilin ComGG Machinery gene
  DQL01_RS10610 comGF/cglF 1970218..1970679 (-) 462 WP_050114150.1 competence type IV pilus minor pilin ComGF Machinery gene
  DQL01_RS10615 comGE/cglE 1970642..1970944 (-) 303 WP_188109891.1 competence type IV pilus minor pilin ComGE Machinery gene
  DQL01_RS10620 comGD/cglD 1970907..1971311 (-) 405 WP_000588022.1 competence type IV pilus minor pilin ComGD Machinery gene
  DQL01_RS10625 comGC/cglC 1971304..1971630 (-) 327 WP_000738634.1 comG operon protein ComGC Machinery gene
  DQL01_RS10630 comGB/cglB 1971632..1972648 (-) 1017 WP_074017570.1 competence type IV pilus assembly protein ComGB Machinery gene
  DQL01_RS10635 comGA/cglA/cilD 1972596..1973537 (-) 942 WP_000249571.1 competence type IV pilus ATPase ComGA Machinery gene
  DQL01_RS10640 - 1973613..1973978 (-) 366 WP_000286415.1 DUF1033 family protein -
  DQL01_RS10645 - 1974129..1975187 (-) 1059 WP_000649466.1 zinc-dependent alcohol dehydrogenase family protein -
  DQL01_RS10650 nagA 1975350..1976501 (-) 1152 WP_061753289.1 N-acetylglucosamine-6-phosphate deacetylase -
  DQL01_RS10655 - 1976654..1978471 (-) 1818 WP_111702741.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35591.51 Da        Isoelectric Point: 6.0083

>NTDB_id=1142096 DQL01_RS10635 WP_000249571.1 1972596..1973537(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain 4041STDY6836166]
MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=1142096 DQL01_RS10635 WP_000249571.1 1972596..1973537(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain 4041STDY6836166]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCAGCTCGGAAAAAAGGGACGCAGGATATTTATTTTGTCCCTAAGTT
AGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGACATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGCCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M3Q7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

99.042

100

0.99
  comGA/cglA/cilD Streptococcus pneumoniae D39

99.042

100

0.99
  comGA/cglA/cilD Streptococcus pneumoniae R6

99.042

100

0.99
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

99.042

100

0.99
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

96.805

100

0.968
  comYA Streptococcus gordonii str. Challis substr. CH1

77.742

99.042

0.77
  comYA Streptococcus mutans UA159

65.916

99.361

0.655
  comYA Streptococcus mutans UA140

65.916

99.361

0.655
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.581

99.042

0.62
  comGA Lactococcus lactis subsp. cremoris KW2

54.808

99.681

0.546
  comGA Latilactobacillus sakei subsp. sakei 23K

42.642

84.665

0.361

Multiple sequence alignment