Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/comE2   Type   Regulator
Locus tag   DQM67_RS10215 Genome accession   NZ_LS483383
Coordinates   1994923..1995666 (-) Length   247 a.a.
NCBI ID   WP_005591384.1    Uniprot ID   A0AAV3EGB4
Organism   Streptococcus cristatus ATCC 51100 strain NCTC 12479     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1989923..2000666
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM67_RS10180 (NCTC12479_01973) - 1990497..1991336 (+) 840 WP_005591389.1 energy-coupling factor ABC transporter ATP-binding protein -
  DQM67_RS10185 (NCTC12479_01974) - 1991329..1992123 (+) 795 WP_005591388.1 energy-coupling factor transporter transmembrane protein EcfT -
  DQM67_RS10595 (NCTC12479_01975) - 1992310..1992969 (+) 660 WP_005591387.1 LysM peptidoglycan-binding domain-containing protein -
  DQM67_RS10195 (NCTC12479_01976) sdaAA 1993025..1993897 (-) 873 WP_005591386.1 L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha -
  DQM67_RS10200 (NCTC12479_01977) sdaAB 1993906..1994577 (-) 672 WP_005592070.1 L-serine ammonia-lyase, iron-sulfur-dependent subunit beta -
  DQM67_RS10215 (NCTC12479_01980) comE/comE2 1994923..1995666 (-) 744 WP_005591384.1 competence system response regulator transcription factor ComE Regulator
  DQM67_RS10220 (NCTC12479_01981) comD/comD1 1995663..1997009 (-) 1347 WP_376738740.1 sensor histidine kinase Regulator
  DQM67_RS10225 (NCTC12479_01982) comC 1997032..1997160 (-) 129 WP_005591382.1 bacteriocin Regulator
  DQM67_RS10235 (NCTC12479_01984) rlmH 1997455..1997934 (-) 480 WP_005591381.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  DQM67_RS10240 (NCTC12479_01985) htrA 1998137..1999315 (+) 1179 WP_005591380.1 S1C family serine protease Regulator
  DQM67_RS10245 (NCTC12479_01986) spo0J 1999378..2000139 (+) 762 WP_005591379.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 247 a.a.        Molecular weight: 29125.42 Da        Isoelectric Point: 7.3958

>NTDB_id=1139541 DQM67_RS10215 WP_005591384.1 1994923..1995666(-) (comE/comE2) [Streptococcus cristatus ATCC 51100 strain NCTC 12479]
MRILALEDTLAHQLRMEKTLAEIAEEMGLDIQVKITGKIQEFKDYVENEDVNQIYFLDIDIKGEETKGLEVARFIRHHNP
YAIIVFVTSKSEFATMTFKYKVSALDFIDKDINDDSFKKRIKECIIYTKNTLITNTNMVDYFEYSYRGNDVRVPFNDILY
IETSSSSHKLRMVGKNFIKEFYGTIASVQEQDEKTQRFFASHKSFLVNIDNICDYDKKTKEIIFYEGRRCPVSRLRTKHL
KEILKNK

Nucleotide


Download         Length: 744 bp        

>NTDB_id=1139541 DQM67_RS10215 WP_005591384.1 1994923..1995666(-) (comE/comE2) [Streptococcus cristatus ATCC 51100 strain NCTC 12479]
ATGAGAATCTTAGCATTAGAAGATACCTTAGCCCACCAACTCCGTATGGAAAAAACTTTAGCAGAGATTGCTGAAGAAAT
GGGGCTCGATATCCAGGTAAAAATCACAGGAAAAATTCAGGAATTTAAGGACTACGTCGAAAATGAAGATGTCAATCAGA
TTTATTTTCTGGATATAGATATTAAAGGGGAAGAGACCAAAGGACTGGAGGTCGCTCGTTTTATTCGTCATCATAATCCA
TATGCTATTATTGTCTTTGTAACTTCAAAATCAGAGTTTGCGACCATGACTTTCAAATACAAGGTATCAGCTCTTGATTT
TATTGACAAGGATATTAACGATGATTCGTTTAAAAAACGTATAAAAGAGTGTATCATTTATACGAAAAATACCTTAATTA
CAAACACCAACATGGTTGATTATTTTGAATACAGCTATCGAGGCAATGATGTGCGCGTGCCATTTAATGATATTTTGTAT
ATCGAAACCTCAAGCTCCTCTCATAAGTTACGGATGGTCGGAAAAAACTTTATAAAAGAATTTTATGGAACGATTGCCAG
TGTTCAAGAACAGGATGAGAAAACCCAACGTTTCTTTGCTTCCCATAAATCTTTCTTAGTCAATATCGATAATATCTGTG
ATTATGATAAGAAAACAAAGGAAATTATATTTTATGAAGGCCGTCGTTGCCCTGTTTCTAGGCTAAGAACAAAACATTTA
AAAGAAATTTTAAAAAATAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(18-121)

LytTr DNA-binding domain (LytTR)

(151-244)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

68.421

100

0.684
  comE/comE2 Streptococcus gordonii strain NCTC7865

68.421

100

0.684
  comE Streptococcus mitis NCTC 12261

62.348

100

0.623
  comE Streptococcus mitis SK321

61.538

100

0.615
  comE Streptococcus pneumoniae TIGR4

61.134

100

0.611
  comE Streptococcus pneumoniae D39

61.134

100

0.611
  comE Streptococcus infantis strain Atu-4

61.134

100

0.611
  comE Streptococcus pneumoniae Rx1

61.134

100

0.611
  comE Streptococcus pneumoniae R6

61.134

100

0.611
  comE/blpR Streptococcus mutans UA159

39.919

100

0.401
  comE/comE1 Streptococcus equinus JB1

38.306

100

0.385
  comE/comE2 Streptococcus equinus JB1

37.551

99.19

0.372

Multiple sequence alignment