Detailed information NTG1139544

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DQM67_RS10240
• Genome accession: NZ_LS483383
• Coordinates: 1998137..1999315 (+)
• Length: 392 a.a.
• NCBI ID: WP_005591380.1
• Uniprot ID: A0AAV3EGJ2
• Organism: Streptococcus cristatus ATCC 51100 strain NCTC 12479
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1993137..2004315

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM67_RS10200 (NCTC12479_01977)	sdaAB	1993906..1994577 (-)	672	WP_005592070.1	L-serine ammonia-lyase, iron-sulfur-dependent subunit beta	-
DQM67_RS10215 (NCTC12479_01980)	comE/comE2	1994923..1995666 (-)	744	WP_005591384.1	competence system response regulator transcription factor ComE	Regulator
DQM67_RS10220 (NCTC12479_01981)	comD/comD1	1995663..1997009 (-)	1347	WP_376738740.1	sensor histidine kinase	Regulator
DQM67_RS10225 (NCTC12479_01982)	comC	1997032..1997160 (-)	129	WP_005591382.1	bacteriocin	Regulator
DQM67_RS10235 (NCTC12479_01984)	rlmH	1997455..1997934 (-)	480	WP_005591381.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQM67_RS10240 (NCTC12479_01985)	htrA	1998137..1999315 (+)	1179	WP_005591380.1	S1C family serine protease	Regulator
DQM67_RS10245 (NCTC12479_01986)	spo0J	1999378..2000139 (+)	762	WP_005591379.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 392 a.a.
• Molecular weight: 41362.51 Da
• Isoelectric Point: 5.8365

>NTDB_id=1139544 DQM67_RS10240 WP_005591380.1 1998137..1999315(+) (htrA) [Streptococcus cristatus ATCC 51100 strain NCTC 12479]
MKNASNFFKKSLLLFIVLVVGFIGGSLGNLTTAFLNNKMANIGPSSSKTTVSTSYKNTTDTTKAVKKVQNAVVSVITYTG
SNQEGVINNESTSDPQVASEGSGVIYKKEGKYAYLVTNTHVLNGAKNPDILLADGNKVPGEVVGSDVYSDISVVRISSEK
VKDVAEFGDSNSLTVGETAIAIGSPLGTEYANSVTQGIISSLGRNVTLQSEDGQNISTTALQTDAAINPGNSGGPLINIQ
GQVIGITSSKISHNGQTAVEGMGFAIPSNDVVNIIKQLEKTGTVTRPALGIQMLDLSNIATSDLAKLRLPSSVKSGILVR
SVQEGMPAENKLQKYDVITKVDDKDVESTSDLQSALYRHSLGDDLKVTYFRDGKEATTTIKLTKSTQDLSDN

Nucleotide

• Length: 1179 bp

>NTDB_id=1139544 DQM67_RS10240 WP_005591380.1 1998137..1999315(+) (htrA) [Streptococcus cristatus ATCC 51100 strain NCTC 12479]
ATGAAAAACGCTTCAAATTTCTTTAAAAAATCTTTGTTGCTTTTTATCGTTTTAGTTGTAGGATTTATTGGCGGAAGCCT
AGGAAATTTAACCACTGCATTTCTTAATAATAAAATGGCTAATATTGGTCCTTCTAGCTCAAAGACCACTGTATCAACGT
CTTATAAAAACACAACCGATACCACAAAGGCTGTAAAAAAGGTTCAAAACGCAGTTGTATCAGTGATTACTTATACAGGT
TCTAATCAAGAAGGAGTGATCAATAATGAATCAACCAGTGATCCTCAAGTAGCTAGTGAGGGATCTGGTGTTATTTATAA
GAAGGAAGGAAAATATGCCTACCTTGTTACCAATACTCACGTTCTAAATGGAGCAAAAAATCCCGATATTCTACTAGCAG
ATGGTAATAAGGTTCCTGGTGAAGTGGTAGGATCAGATGTTTATTCTGATATTTCTGTAGTAAGAATTAGCTCTGAAAAG
GTGAAAGATGTAGCTGAATTTGGAGATTCCAACTCCCTGACAGTAGGAGAAACTGCTATTGCCATCGGAAGCCCTCTCGG
AACAGAATACGCTAACTCTGTTACACAAGGAATCATCTCTAGTTTAGGCAGAAATGTAACTCTCCAATCTGAAGACGGCC
AAAATATTTCCACGACTGCCTTGCAAACAGATGCTGCTATCAACCCTGGTAACTCTGGTGGCCCACTCATCAATATCCAA
GGGCAAGTTATCGGTATTACGTCCAGCAAAATCTCTCACAATGGTCAAACTGCTGTAGAAGGCATGGGCTTTGCAATCCC
ATCAAACGATGTTGTCAACATTATCAAGCAATTAGAAAAAACTGGAACAGTAACTCGTCCTGCTCTGGGTATCCAAATGC
TCGATTTATCTAATATCGCCACTTCTGACTTAGCAAAATTACGTCTGCCTTCATCTGTAAAATCAGGTATCCTTGTCCGC
TCTGTGCAAGAAGGAATGCCTGCTGAAAATAAACTTCAGAAATACGATGTCATCACAAAAGTTGACGATAAGGATGTTGA
GTCAACCAGTGATTTACAATCTGCTCTCTACAGACATTCTCTGGGAGATGACTTGAAAGTGACTTACTTTAGGGATGGTA
AAGAGGCTACTACAACAATTAAATTGACCAAATCAACCCAGGACTTAAGTGACAACTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (101-246)

• Peptidase family M50 (Peptidase_M50) (233-386)

• PDZ domain (PDZ_2) (287-382)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	67.848	100	0.684
htrA	Streptococcus pneumoniae Rx1	64.194	99.745	0.64
htrA	Streptococcus pneumoniae D39	64.194	99.745	0.64
htrA	Streptococcus pneumoniae R6	64.194	99.745	0.64
htrA	Streptococcus pneumoniae TIGR4	64.194	99.745	0.64
htrA	Streptococcus mitis NCTC 12261	64.194	99.745	0.64
htrA	Streptococcus mutans UA159	54.839	100	0.564