Detailed information NTG1121303

Bioinformatically predicted

Overview

• Name: comX/sigX/comX2/sigX2
• Type: Regulator
• Locus tag: EL136_RS10645
• Genome accession: NZ_LR134317
• Coordinates: 2227643..2228128 (+)
• Length: 161 a.a.
• NCBI ID: WP_014623459.1
• Uniprot ID: A0A6D2L510
• Organism: Streptococcus equi subsp. zooepidemicus strain NCTC6180
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	2226190..2227199	2227643..2228128	flank	444

Gene organization within MGE regions

Location: 2226190..2228128

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL136_RS10635 (NCTC6180_02179)	-	2226190..2227328 (+)	1139	Protein_2078	ISAs1 family transposase	-
EL136_RS10645 (NCTC6180_02181)	comX/sigX/comX2/sigX2	2227643..2228128 (+)	486	WP_014623459.1	hypothetical protein	Regulator

Sequence

Protein

• Length: 161 a.a.
• Molecular weight: 19403.39 Da
• Isoelectric Point: 8.2702

>NTDB_id=1121303 EL136_RS10645 WP_014623459.1 2227643..2228128(+) (comX/sigX/comX2/sigX2) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
MTDDLVRLFDKIKPIIMKLRRHYYIQLWELDDWLQEGRLILYRLLVTYPELIEDEEKLYRYFKTKFSSYLKDVLRQQESQ
KRRFHKMAYEEIGSVGHAIPAGGLGVDDYVAYQLIVKEVEERLTESELSQFRALIRGERFEGRRALLRKIGPYFQDFTGE
K

Nucleotide

• Length: 486 bp

>NTDB_id=1121303 EL136_RS10645 WP_014623459.1 2227643..2228128(+) (comX/sigX/comX2/sigX2) [Streptococcus equi subsp. zooepidemicus strain NCTC6180]
ATGACTGATGATTTAGTGAGGTTGTTTGATAAGATCAAGCCTATTATTATGAAGCTAAGACGGCATTATTATATTCAGCT
GTGGGAGCTAGATGATTGGTTACAGGAGGGGCGGTTGATCTTGTATCGGTTATTGGTCACTTATCCAGAATTGATAGAGG
ATGAGGAGAAGCTGTATCGTTATTTTAAGACCAAGTTTTCCTCTTATTTGAAGGACGTGTTGCGGCAGCAGGAGAGTCAG
AAGCGTCGGTTTCATAAGATGGCTTATGAGGAGATTGGGTCGGTAGGCCATGCGATACCAGCAGGTGGCTTGGGAGTAGA
TGATTATGTGGCTTATCAGTTGATTGTGAAGGAGGTTGAGGAGCGATTGACAGAGAGTGAGCTGTCGCAGTTTCGGGCTT
TGATCAGGGGAGAGCGGTTTGAGGGGAGACGGGCCTTGCTTCGCAAGATAGGACCTTACTTTCAGGACTTTACTGGTGAG
AAATAA

Domains

No domain identified.

3D structure

• AlphaFold DB: A0A6D2L510

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	67.5	99.379	0.671
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	67.5	99.379	0.671
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	67.5	99.379	0.671
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	67.5	99.379	0.671
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	70.395	94.41	0.665
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	70.395	94.41	0.665
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	47.742	96.273	0.46
comX/sigX	Streptococcus mutans UA159	46.497	97.516	0.453
comX	Streptococcus sobrinus strain NIDR 6715-7	45.752	95.031	0.435
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	40.667	93.168	0.379
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	40.397	93.789	0.379
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	40.397	93.789	0.379
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	39.333	93.168	0.366
comX/comX2	Streptococcus pneumoniae TIGR4	38.411	93.789	0.36
comX/comX1	Streptococcus pneumoniae TIGR4	38.411	93.789	0.36
comX/comX2	Streptococcus pneumoniae Rx1	38.411	93.789	0.36
comX/comX1	Streptococcus pneumoniae Rx1	38.411	93.789	0.36
comX/comX2	Streptococcus pneumoniae D39	38.411	93.789	0.36
comX/comX1	Streptococcus pneumoniae D39	38.411	93.789	0.36
comX/comX2	Streptococcus pneumoniae R6	38.411	93.789	0.36
comX/comX1	Streptococcus pneumoniae R6	38.411	93.789	0.36
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	38.667	93.168	0.36
comX	Streptococcus thermophilus LMG 18311	37.908	95.031	0.36
comX	Streptococcus thermophilus LMD-9	37.908	95.031	0.36