Detailed information NTG1120232

Bioinformatically predicted

Overview

• Name: comYC
• Type: Machinery gene
• Locus tag: EL087_RS01000
• Genome accession: NZ_LR134288
• Coordinates: 190114..190431 (+)
• Length: 105 a.a.
• NCBI ID: WP_003028473.1
• Uniprot ID: A0A0P0N5S2
• Organism: Streptococcus milleri strain NCTC11169
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 185114..195431

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL087_RS00970 (NCTC11169_00189)	-	185242..185772 (+)	531	WP_126406225.1	FUSC family protein	-
EL087_RS00975 (NCTC11169_00190)	-	185849..186208 (+)	360	WP_003028467.1	MerR family transcriptional regulator	-
EL087_RS00980 (NCTC11169_00191)	glnA	186246..187592 (+)	1347	WP_106079126.1	type I glutamate--ammonia ligase	-
EL087_RS00985 (NCTC11169_00192)	-	187777..188142 (+)	366	WP_126406228.1	DUF1033 family protein	-
EL087_RS00990 (NCTC11169_00193)	comYA	188212..189153 (+)	942	WP_126406231.1	competence type IV pilus ATPase ComGA	Machinery gene
EL087_RS00995 (NCTC11169_00194)	comYB	189095..190117 (+)	1023	WP_182465780.1	competence type IV pilus assembly protein ComGB	Machinery gene
EL087_RS01000 (NCTC11169_00195)	comYC	190114..190431 (+)	318	WP_003028473.1	competence type IV pilus major pilin ComGC	Machinery gene
EL087_RS01005 (NCTC11169_00196)	comYD	190391..190819 (+)	429	WP_037566697.1	competence type IV pilus minor pilin ComGD	Machinery gene
EL087_RS01010 (NCTC11169_00197)	comGE/cglE	190791..191084 (+)	294	WP_126406234.1	competence type IV pilus minor pilin ComGE	Machinery gene
EL087_RS01015 (NCTC11169_00198)	comGF/cglF	191068..191505 (+)	438	WP_049513212.1	competence type IV pilus minor pilin ComGF	Machinery gene
EL087_RS01020 (NCTC11169_00199)	comGG	191486..191812 (+)	327	WP_269470973.1	competence type IV pilus minor pilin ComGG	-
EL087_RS01025 (NCTC11169_00200)	comYH	191884..192837 (+)	954	WP_003039058.1	class I SAM-dependent methyltransferase	Machinery gene
EL087_RS01030 (NCTC11169_00201)	-	192884..194083 (+)	1200	WP_126406237.1	acetate kinase	-

Sequence

Protein

• Length: 105 a.a.
• Molecular weight: 11622.72 Da
• Isoelectric Point: 10.1006

>NTDB_id=1120232 EL087_RS01000 WP_003028473.1 190114..190431(+) (comYC) [Streptococcus milleri strain NCTC11169]
MKKLKSLKVKGFTLVEMLVVLLIISVLMLLFVPNLTKQKEAVTEKGNAAVVKVVESQAELFEVNHTNEKATLSKLVNEGT
ITDKQAASYKAYYAKHTKEARSVAD

Nucleotide

• Length: 318 bp

>NTDB_id=1120232 EL087_RS01000 WP_003028473.1 190114..190431(+) (comYC) [Streptococcus milleri strain NCTC11169]
ATGAAAAAATTAAAAAGTTTGAAGGTTAAAGGTTTTACTTTAGTAGAGATGTTAGTCGTGCTTCTTATCATCAGTGTTTT
GATGCTCTTATTTGTACCGAATTTGACCAAGCAAAAAGAAGCGGTGACGGAAAAAGGAAATGCAGCGGTGGTAAAAGTTG
TGGAAAGCCAAGCGGAGCTGTTTGAGGTCAATCACACTAATGAAAAAGCGACACTCTCAAAATTAGTCAACGAAGGCACG
ATTACAGACAAGCAAGCGGCATCTTATAAGGCTTACTATGCGAAACATACAAAAGAAGCTCGTTCCGTTGCAGATTAA

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (8-30)

3D structure

• AlphaFold DB: A0A0P0N5S2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYC	Streptococcus gordonii str. Challis substr. CH1	73.333	100	0.733
comYC	Streptococcus mutans UA159	66.667	100	0.667
comYC	Streptococcus mutans UA140	66.667	100	0.667
comGC/cglC	Streptococcus mitis NCTC 12261	68.627	97.143	0.667
comGC/cglC	Streptococcus mitis SK321	68.627	97.143	0.667
comGC/cglC	Streptococcus pneumoniae R6	66.667	97.143	0.648
comGC/cglC	Streptococcus pneumoniae D39	66.667	97.143	0.648
comGC/cglC	Streptococcus pneumoniae Rx1	66.667	97.143	0.648
comGC/cglC	Streptococcus pneumoniae TIGR4	66.667	97.143	0.648
comYC	Streptococcus suis isolate S10	66.292	84.762	0.562
comGC	Lactococcus lactis subsp. cremoris KW2	54.808	99.048	0.543