Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   AABA19_RS09850 Genome accession   NZ_AP028609
Coordinates   1911220..1912161 (-) Length   313 a.a.
NCBI ID   WP_016398028.1    Uniprot ID   A0A0U0BVC9
Organism   Streptococcus pneumoniae strain Sep4     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1906220..1917161
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AABA19_RS09810 (TKY121806_19120) comYH 1906706..1907659 (-) 954 WP_338170756.1 class I SAM-dependent methyltransferase Machinery gene
  AABA19_RS09815 - 1907720..1908314 (-) 595 Protein_1910 class I SAM-dependent methyltransferase -
  AABA19_RS09820 (TKY121806_19150) comGG/cglG 1908451..1908864 (-) 414 WP_050114148.1 competence type IV pilus minor pilin ComGG Machinery gene
  AABA19_RS09825 (TKY121806_19160) comGF/cglF 1908842..1909303 (-) 462 WP_063643062.1 competence type IV pilus minor pilin ComGF Machinery gene
  AABA19_RS09830 (TKY121806_19170) comGE/cglE 1909266..1909568 (-) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  AABA19_RS09835 (TKY121806_19180) comGD/cglD 1909531..1909935 (-) 405 WP_000588023.1 competence type IV pilus minor pilin ComGD Machinery gene
  AABA19_RS09840 (TKY121806_19190) comGC/cglC 1909928..1910254 (-) 327 WP_061630249.1 comG operon protein ComGC Machinery gene
  AABA19_RS09845 (TKY121806_19200) comGB/cglB 1910256..1911272 (-) 1017 WP_075270915.1 competence type IV pilus assembly protein ComGB Machinery gene
  AABA19_RS09850 (TKY121806_19210) comGA/cglA/cilD 1911220..1912161 (-) 942 WP_016398028.1 competence type IV pilus ATPase ComGA Machinery gene
  AABA19_RS09855 (TKY121806_19220) - 1912237..1912602 (-) 366 WP_000286415.1 DUF1033 family protein -
  AABA19_RS09860 (TKY121806_19230) - 1912753..1913811 (-) 1059 WP_000649468.1 zinc-dependent alcohol dehydrogenase family protein -
  AABA19_RS09865 (TKY121806_19240) nagA 1913974..1915125 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  AABA19_RS09870 (TKY121806_19250) - 1915278..1917095 (-) 1818 WP_001220848.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35546.46 Da        Isoelectric Point: 6.0083

>NTDB_id=106470 AABA19_RS09850 WP_016398028.1 1911220..1912161(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain Sep4]
MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKIASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFASRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=106470 AABA19_RS09850 WP_016398028.1 1911220..1912161(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain Sep4]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCAGCTCGGAAAAAAGGGACGCAGGATATCTATTTTGTCCCTAAGTT
AGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATAGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAGCAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0U0BVC9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

99.681

100

0.997
  comGA/cglA/cilD Streptococcus pneumoniae D39

99.681

100

0.997
  comGA/cglA/cilD Streptococcus pneumoniae R6

99.681

100

0.997
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

99.681

100

0.997
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

96.166

100

0.962
  comYA Streptococcus gordonii str. Challis substr. CH1

78.065

99.042

0.773
  comYA Streptococcus mutans UA159

65.916

99.361

0.655
  comYA Streptococcus mutans UA140

65.916

99.361

0.655
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.581

99.042

0.62
  comGA Lactococcus lactis subsp. cremoris KW2

54.808

99.681

0.546
  comGA Latilactobacillus sakei subsp. sakei 23K

42.642

84.665

0.361

Multiple sequence alignment