Detailed information NTG1052157

Bioinformatically predicted

Overview

• Name: comX/comX2
• Type: Regulator
• Locus tag: ACE2AN_RS00070
• Genome accession: NZ_CP169564
• Coordinates: 14254..14733 (+)
• Length: 159 a.a.
• NCBI ID: WP_000588897.1
• Uniprot ID: Q9R2W8
• Organism: Streptococcus pneumoniae strain 6_2F1
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	12174..39052	14254..14733	within	0

Gene organization within MGE regions

Location: 12174..39052

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACE2AN_RS00065	ftsH	12174..14132 (+)	1959	WP_000744557.1	ATP-dependent zinc metalloprotease FtsH	-
ACE2AN_RS00070	comX/comX2	14254..14733 (+)	480	WP_000588897.1	sigma-70 family RNA polymerase sigma factor	Regulator
ACE2AN_RS00105	-	20283..20492 (+)	210	Protein_14	transposase	-
ACE2AN_RS00110	-	20527..21324 (-)	798	Protein_15	transposase	-
ACE2AN_RS00115	comW	21590..21826 (+)	237	WP_000939546.1	sigma(X)-activator ComW	Regulator
ACE2AN_RS00120	-	22057..23343 (+)	1287	WP_000205044.1	adenylosuccinate synthase	-
ACE2AN_RS00125	tadA	23544..24011 (+)	468	WP_000291875.1	tRNA adenosine(34) deaminase TadA	-
ACE2AN_RS00135	-	24220..25356 (-)	1137	WP_001824497.1	site-specific integrase	-
ACE2AN_RS00140	-	25417..26487 (-)	1071	WP_000401841.1	type I restriction endonuclease	-
ACE2AN_RS00145	-	26504..26884 (-)	381	WP_081528400.1	ImmA/IrrE family metallo-endopeptidase	-
ACE2AN_RS00150	-	26897..27160 (-)	264	WP_000285962.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ACE2AN_RS00155	-	27160..27393 (-)	234	WP_000156419.1	hypothetical protein	-
ACE2AN_RS00160	-	27393..27761 (-)	369	WP_000464160.1	helix-turn-helix domain-containing protein	-
ACE2AN_RS00165	-	28175..28414 (-)	240	WP_000142893.1	hypothetical protein	-
ACE2AN_RS00170	-	28479..28670 (+)	192	WP_001112859.1	DNA-binding protein	-
ACE2AN_RS00175	-	28693..28896 (+)	204	WP_001247549.1	hypothetical protein	-
ACE2AN_RS00180	-	29051..29218 (-)	168	WP_000024181.1	YjzC family protein	-
ACE2AN_RS00185	-	29223..29603 (+)	381	Protein_29	autolysin	-
ACE2AN_RS00190	-	29888..30331 (+)	444	WP_000701992.1	dUTP diphosphatase	-
ACE2AN_RS00195	-	30333..30848 (+)	516	WP_061372761.1	histidine phosphatase family protein	-
ACE2AN_RS00200	radA	30862..32223 (+)	1362	WP_074017595.1	DNA repair protein RadA	Machinery gene
ACE2AN_RS00205	-	32296..32793 (+)	498	WP_001809263.1	carbonic anhydrase	-
ACE2AN_RS00210	-	32818..33601 (+)	784	Protein_34	PrsW family glutamic-type intramembrane protease	-
ACE2AN_RS00215	-	33746..34714 (+)	969	WP_000010163.1	ribose-phosphate diphosphokinase	-
ACE2AN_RS00220	-	34848..35129 (-)	282	Protein_36	transposase family protein	-
ACE2AN_RS00225	-	35256..36163 (-)	908	Protein_37	Rpn family recombination-promoting nuclease/putative transposase	-
ACE2AN_RS00230	polA	36419..39052 (+)	2634	WP_024478011.1	DNA polymerase I	-

Sequence

Protein

• Length: 159 a.a.
• Molecular weight: 19873.52 Da
• Isoelectric Point: 7.3797

>NTDB_id=1052157 ACE2AN_RS00070 WP_000588897.1 14254..14733(+) (comX/comX2) [Streptococcus pneumoniae strain 6_2F1]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISREEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

Nucleotide

• Length: 480 bp

>NTDB_id=1052157 ACE2AN_RS00070 WP_000588897.1 14254..14733(+) (comX/comX2) [Streptococcus pneumoniae strain 6_2F1]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTTTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGACCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGTAGACGATATTCCAC
GTTTAAGGAAATATTTCAAAACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAGCAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGAGAGATCAGTCATCGTATAAGTGAGGGGGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCACTAG

Domains

No domain identified.

3D structure

• AlphaFold DB: Q9R2W8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/comX2	Streptococcus pneumoniae Rx1	100	100	1
comX/comX1	Streptococcus pneumoniae Rx1	100	100	1
comX/comX2	Streptococcus pneumoniae D39	100	100	1
comX/comX1	Streptococcus pneumoniae D39	100	100	1
comX/comX2	Streptococcus pneumoniae R6	100	100	1
comX/comX1	Streptococcus pneumoniae R6	100	100	1
comX/comX2	Streptococcus pneumoniae TIGR4	99.371	100	0.994
comX/comX1	Streptococcus pneumoniae TIGR4	99.371	100	0.994
comX/sigX/comX1/sigX1	Streptococcus mitis NCTC 12261	92.453	100	0.925
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	92.453	100	0.925
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	90.566	100	0.906
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	89.241	99.371	0.887
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comX/sigX	Streptococcus mutans UA159	46	94.34	0.434
comX/sigX	Streptococcus suis isolate S10	45.695	94.969	0.434
comX/sigX	Streptococcus suis D9	45.695	94.969	0.434
comX/sigX	Streptococcus suis P1/7	45.695	94.969	0.434
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	40	94.34	0.377