Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 3621..4272 Replicon plasmid pAB120
Accession NC_019359
Organism Acinetobacter baumannii

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HPE87_RS00025 Protein ID WP_000269902.1
Coordinates 3621..3977 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HPE87_RS00030 Protein ID WP_001140622.1
Coordinates 3970..4272 (+) Length 101 a.a.

Genomic Context

HPE87_RS00005HPE87_RS00010HPE87_RS00015HPE87_RS00025HPE87_RS00030HPE87_RS00035HPE87_RS00020HPE87_RS00040HPE87_RS00045HPE87_RS00050HPE87_RS00055
Location: 322..1272 (951 bp)
Type: Others
Protein ID: WP_001205343.1
Location: 1265..1840 (576 bp)
Type: Others
Protein ID: WP_001096616.1
Location: 1860..2003 (144 bp)
Type: Others
Protein ID: WP_001125246.1
Location: 3621..3977 (357 bp)
Type: Toxin
Protein ID: WP_000269902.1
Location: 3970..4272 (303 bp)
Type: Antitoxin
Protein ID: WP_001140622.1
Location: 4265..4474 (210 bp)
Type: Others
Protein ID: WP_000069473.1
Location: 2185..3012 (828 bp)
Type: Others
Protein ID: WP_000713530.1
Location: 4800..5261 (462 bp)
Type: Others
Protein ID: WP_000761346.1
Location: 5567..7978 (2412 bp)
Type: Others
Protein ID: WP_000932953.1
Location: 8106..8420 (315 bp)
Type: Others
Protein ID: WP_001983304.1
Location: 8407..8694 (288 bp)
Type: Others
Protein ID: WP_000438826.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HPE87_RS00005 (pAB120_01)322..1272+951WP_001205343.1replication initiation protein RepM-
HPE87_RS00010 (pAB120_02)1265..1840+576WP_001096616.1plasmid replication DNA-binding protein-
HPE87_RS000151860..2003+144WP_001125246.1hypothetical protein-
HPE87_RS00020 (pAB120_03)2185..3012-828WP_000713530.1OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72-
HPE87_RS00025 (pAB120_04)3621..3977+357WP_000269902.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HPE87_RS00030 (pAB120_05)3970..4272+303WP_001140622.1XRE family transcriptional regulatorAntitoxin
HPE87_RS00035 (pAB120_06)4265..4474+210WP_000069473.1hypothetical protein-
HPE87_RS00040 (pAB120_07)4800..5261-462WP_000761346.1DIP1984 family protein-
HPE87_RS00045 (pAB120_08)5567..7978-2412WP_000932953.1TonB-dependent receptor ZnuD2-
HPE87_RS00050 (pAB120_09)8106..8420-315WP_001983304.1BrnA antitoxin family protein-
HPE87_RS00055 (pAB120_10)8407..8694-288WP_000438826.1BrnT family toxin-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideNon-Mobilizable plasmidblaOXA-72-1..1087910879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13487.44 Da        Isoelectric Point: 6.4631

>T10169 WP_000269902.1 NC_019359:3621-3977 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

>T10169 NC_019359:3621-3977 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCTGATCAGCAATACGAACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11178.98 Da        Isoelectric Point: 6.7282

>AT10169 WP_001140622.1 NC_019359:3970-4272 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT10169 NC_019359:3970-4272 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAGGCTCGTATTCAACAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACCATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T10063Escherichia coli strain Ec158

51

100

0.51

T10050Mycobacterium tuberculosis H37Rv

44.348

97.458

0.432

T127Mycobacterium tuberculosis H37Rv

44.545

96.491

0.43

T6105Burkholderia pseudomallei K96243

27.778

100

0.306

T6106Burkholderia pseudomallei K96243

27.778

100

0.306
Showing 1 to 5 of 5 rows

Multiple sequence alignment    


Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT10063Escherichia coli strain Ec158

51

100

0.51

AT10050Mycobacterium tuberculosis H37Rv

34.375

96

0.33
Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References

(1) Julija Armalytė et al. (2018) The higBA Toxin-Antitoxin Module From the Opportunistic Pathogen Acinetobacter baumannii - Regulation, Activity, and Evolution. Frontiers in Microbiology 9:732. [PubMed:29706946] experimental


experimental experimental literature