Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 13826..14477 Replicon plasmid p1OC043
Accession NZ_CP087322
Organism Acinetobacter baumannii strain OC043

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LO002_RS19280 Protein ID WP_000269902.1
Coordinates 13826..14182 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LO002_RS19285 Protein ID WP_001140622.1
Coordinates 14175..14477 (+) Length 101 a.a.

Genomic Context

LO002_RS19260LO002_RS19265LO002_RS19270LO002_RS19280LO002_RS19285LO002_RS19290LO002_RS19255LO002_RS19275LO002_RS19295LO002_RS19300LO002_RS19305LO002_RS19310
Location: 10526..11476 (951 bp)
Type: Others
Protein ID: WP_001205343.1
Location: 11469..12044 (576 bp)
Type: Others
Protein ID: WP_001096616.1
Location: 12064..12207 (144 bp)
Type: Others
Protein ID: WP_001125246.1
Location: 13826..14182 (357 bp)
Type: Toxin
Protein ID: WP_000269902.1
Location: 14175..14477 (303 bp)
Type: Antitoxin
Protein ID: WP_001140622.1
Location: 14470..14679 (210 bp)
Type: Others
Protein ID: WP_000069473.1
Location: 9199..9390 (192 bp)
Type: Others
Protein ID: WP_000032259.1
Location: 12390..13217 (828 bp)
Type: Others
Protein ID: WP_000713530.1
Location: 15005..15466 (462 bp)
Type: Others
Protein ID: WP_000761346.1
Location: 15771..18182 (2412 bp)
Type: Others
Protein ID: WP_000932953.1
Location: 18309..18623 (315 bp)
Type: Others
Protein ID: WP_001983304.1
Location: 18610..18897 (288 bp)
Type: Others
Protein ID: WP_000438826.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LO002_RS192559199..9390-192WP_000032259.1hypothetical protein-
LO002_RS1926010526..11476+951WP_001205343.1replication initiation protein RepM-
LO002_RS1926511469..12044+576WP_001096616.1plasmid replication DNA-binding protein-
LO002_RS1927012064..12207+144WP_001125246.1hypothetical protein-
LO002_RS1927512390..13217-828WP_000713530.1OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72-
LO002_RS1928013826..14182+357WP_000269902.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LO002_RS1928514175..14477+303WP_001140622.1XRE family transcriptional regulatorAntitoxin
LO002_RS1929014470..14679+210WP_000069473.1hypothetical protein-
LO002_RS1929515005..15466-462WP_000761346.1DIP1984 family protein-
LO002_RS1930015771..18182-2412WP_000932953.1TonB-dependent receptor ZnuD2-
LO002_RS1930518309..18623-315WP_001983304.1BrnA antitoxin family protein-
LO002_RS1931018610..18897-288WP_000438826.1BrnT family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideNon-Mobilizable plasmidblaOXA-72-1..2154221542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13487.44 Da        Isoelectric Point: 6.4631

>T225354 WP_000269902.1 NZ_CP087322:13826-14182 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

>T225354 NZ_CP121137:4455865-4456212 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAATCGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11178.98 Da        Isoelectric Point: 6.7282

>AT225354 WP_001140622.1 NZ_CP087322:14175-14477 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT225354 NZ_CP121137:4456212-4456511 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References