225354

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 13826..14477 Replicon plasmid p1OC043
Accession NZ_CP087322
Organism Acinetobacter baumannii strain OC043

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LO002_RS19280 Protein ID WP_000269902.1
Coordinates 13826..14182 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LO002_RS19285 Protein ID WP_001140622.1
Coordinates 14175..14477 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO002_RS19255 9199..9390 - 192 WP_000032259.1 hypothetical protein -
LO002_RS19260 10526..11476 + 951 WP_001205343.1 replication initiation protein RepM -
LO002_RS19265 11469..12044 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
LO002_RS19270 12064..12207 + 144 WP_001125246.1 hypothetical protein -
LO002_RS19275 12390..13217 - 828 WP_000713530.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72 -
LO002_RS19280 13826..14182 + 357 WP_000269902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO002_RS19285 14175..14477 + 303 WP_001140622.1 XRE family transcriptional regulator Antitoxin
LO002_RS19290 14470..14679 + 210 WP_000069473.1 hypothetical protein -
LO002_RS19295 15005..15466 - 462 WP_000761346.1 DIP1984 family protein -
LO002_RS19300 15771..18182 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
LO002_RS19305 18309..18623 - 315 WP_001983304.1 BrnA antitoxin family protein -
LO002_RS19310 18610..18897 - 288 WP_000438826.1 BrnT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid blaOXA-72 - 1..21542 21542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13487.44 Da        Isoelectric Point: 6.4631

>T225354 WP_000269902.1 NZ_CP087322:13826-14182 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

>T225354 NZ_CP121137:4455865-4456212 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAATCGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11178.98 Da        Isoelectric Point: 6.7282

>AT225354 WP_001140622.1 NZ_CP087322:14175-14477 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT225354 NZ_CP121137:4456212-4456511 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References