225355

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 4251..4839 Replicon plasmid p2OC043
Accession NZ_CP087323
Organism Acinetobacter baumannii strain OC043

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag LO002_RS19360 Protein ID WP_000438826.1
Coordinates 4552..4839 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag LO002_RS19355 Protein ID WP_001983304.1
Coordinates 4251..4565 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO002_RS19330 1..123 + 123 Protein_0 type II toxin-antitoxin system RelE/ParE family toxin -
LO002_RS19335 116..418 + 303 WP_001140622.1 XRE family transcriptional regulator -
LO002_RS19340 411..620 + 210 WP_000069473.1 hypothetical protein -
LO002_RS19345 946..1407 - 462 WP_000761346.1 DIP1984 family protein -
LO002_RS19350 1712..4123 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
LO002_RS19355 4251..4565 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
LO002_RS19360 4552..4839 - 288 WP_000438826.1 BrnT family toxin Toxin
LO002_RS19365 5148..5975 + 828 WP_000713530.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72 -
LO002_RS19370 6019..6210 - 192 WP_000032259.1 hypothetical protein -
LO002_RS19375 7346..8296 + 951 WP_001205343.1 replication initiation protein RepM -
LO002_RS19380 8289..8864 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
LO002_RS19385 8884..9027 + 144 WP_001125246.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid blaOXA-72 - 1..15932 15932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T225355 WP_000438826.1 NZ_CP087323:c4839-4552 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T225355 NZ_CP121137:4900044-4900454 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGATGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT225355 WP_001983304.1 NZ_CP087323:c4565-4251 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT225355 NZ_CP121137:4899797-4900063 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References