Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2647..3235 Replicon plasmid p1OC043
Accession NZ_CP087322
Organism Acinetobacter baumannii strain OC043

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag LO002_RS19215 Protein ID WP_000438826.1
Coordinates 2647..2934 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag LO002_RS19220 Protein ID WP_001983304.1
Coordinates 2921..3235 (+) Length 105 a.a.

Genomic Context

LO002_RS19205LO002_RS19215LO002_RS19220LO002_RS19225LO002_RS19230LO002_RS19200LO002_RS19210LO002_RS19235LO002_RS19240LO002_RS19245
Location: 1276..1467 (192 bp)
Type: Others
Protein ID: WP_000032259.1
Location: 2647..2934 (288 bp)
Type: Toxin
Protein ID: WP_000438826.1
Location: 2921..3235 (315 bp)
Type: Antitoxin
Protein ID: WP_001983304.1
Location: 3363..5774 (2412 bp)
Type: Others
Protein ID: WP_000932953.1
Location: 6079..6540 (462 bp)
Type: Others
Protein ID: WP_000761346.1
Location: 1..140 (140 bp)
Type: Others
Protein ID: WP_258579767.1
Location: 1511..2338 (828 bp)
Type: Others
Protein ID: WP_000713530.1
Location: 6866..7075 (210 bp)
Type: Others
Protein ID: WP_000069473.1
Location: 7068..7370 (303 bp)
Type: Others
Protein ID: WP_001140622.1
Location: 7363..7719 (357 bp)
Type: Others
Protein ID: WP_000269902.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LO002_RS192001..140-140WP_258579767.1replication initiation protein-
LO002_RS192051276..1467+192WP_000032259.1hypothetical protein-
LO002_RS192101511..2338-828WP_000713530.1OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72-
LO002_RS192152647..2934+288WP_000438826.1BrnT family toxinToxin
LO002_RS192202921..3235+315WP_001983304.1BrnA antitoxin family proteinAntitoxin
LO002_RS192253363..5774+2412WP_000932953.1TonB-dependent receptor ZnuD2-
LO002_RS192306079..6540+462WP_000761346.1DIP1984 family protein-
LO002_RS192356866..7075-210WP_000069473.1hypothetical protein-
LO002_RS192407068..7370-303WP_001140622.1XRE family transcriptional regulator-
LO002_RS192457363..7719-357WP_000269902.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideNon-Mobilizable plasmidblaOXA-72-1..2154221542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T225352 WP_000438826.1 NZ_CP087322:2647-2934 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T225352 NZ_CP121137:4303052-4303537 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATGCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT225352 WP_001983304.1 NZ_CP087322:2921-3235 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT225352 NZ_CP121137:4302798-4303064 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3G6Z3M6

Antitoxin

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Source
ID
Structure
AlphaFold DBN9M5I3

References