Detailed information of TA system TA109196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 6607..7258
• Replicon: plasmid pAB120
• Accession: NZ_CP031446
• Organism: Acinetobacter baumannii strain MDR-UNC

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DYB08_RS20085
• Protein ID: WP_000269902.1
• Coordinates: 6902..7258 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DYB08_RS20080
• Protein ID: WP_001140622.1
• Coordinates: 6607..6909 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DYB08_RS20055	2186..2473	+	288	WP_000438826.1	BrnT family toxin	-
DYB08_RS20060	2460..2774	+	315	WP_001983304.1	BrnA antitoxin family protein	-
DYB08_RS20065	2902..5313	+	2412	WP_000932953.1	TonB-dependent receptor ZnuD2	-
DYB08_RS20070	5618..6079	+	462	WP_000761346.1	DIP1984 family protein	-
DYB08_RS20075	6405..6614	-	210	WP_000069473.1	hypothetical protein	-
DYB08_RS20080	6607..6909	-	303	WP_001140622.1	XRE family transcriptional regulator	Antitoxin
DYB08_RS20085	6902..7258	-	357	WP_000269902.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DYB08_RS20090	7867..8694	+	828	WP_000713530.1	OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72	-
DYB08_RS20195	8877..9020	-	144	WP_001125246.1	hypothetical protein	-
DYB08_RS20095	9040..9615	-	576	WP_001096616.1	helix-turn-helix domain-containing protein	-
DYB08_RS20100	9608..10558	-	951	WP_001205343.1	replication initiation protein RepM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_019359 Acinetobacter baumannii Non-Mobilizable plasmid TA010169 1..10879 0	inside	Non-Mobilizable plasmid	blaOXA-72	-	1..10879	10879

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (13-89)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13487.44 Da
• Isoelectric Point: 6.4631

>T109196 WP_000269902.1 NZ_CP031446:c7258-6902 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T109196 NZ_CP031446:c7258-6902 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCTGATCAGCAATACGAACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11178.98 Da
• Isoelectric Point: 6.7282

>AT109196 WP_001140622.1 NZ_CP031446:c6909-6607 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT109196 NZ_CP031446:c6909-6607 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACCATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA