Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1435651..1437660 Replicon chromosome
Accession NC_006351
Organism Burkholderia pseudomallei K96243

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BPS_RS24505 Protein ID WP_024431052.1
Coordinates 1437364..1437660 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BPS_RS24510 Protein ID WP_009971793.1
Coordinates 1437663..1438019 (+) Length 119 a.a.

Genomic Context

BPS_RS24460BPS_RS24465BPS_RS24470BPS_RS24475BPS_RS24480BPS_RS24485BPS_RS24490BPS_RS24495BPS_RS24500BPS_RS24505BPS_RS24510BPS_RS24525BPS_RS24515BPS_RS24520
Location: 1430773..1430895 (123 bp)
Type: Others
Protein ID: WP_006027270.1
Location: 1430895..1432688 (1794 bp)
Type: Others
Protein ID: WP_009971786.1
Location: 1432704..1432970 (267 bp)
Type: Others
Protein ID: WP_009971787.1
Location: 1432967..1433173 (207 bp)
Type: Others
Protein ID: WP_004532731.1
Location: 1433263..1433916 (654 bp)
Type: Others
Protein ID: WP_004532770.1
Location: 1434150..1434272 (123 bp)
Type: Others
Protein ID: WP_009897078.1
Location: 1434375..1434908 (534 bp)
Type: Others
Protein ID: WP_004532793.1
Location: 1434905..1435642 (738 bp)
Type: Others
Protein ID: WP_011205520.1
Location: 1435657..1436772 (1116 bp)
Type: Others
Protein ID: WP_029670743.1
Location: 1437364..1437660 (297 bp)
Type: Toxin
Protein ID: WP_024431052.1
Location: 1437663..1438019 (357 bp)
Type: Antitoxin
Protein ID: WP_009971793.1
Location: 1441028..1441837 (810 bp)
Type: Others
Protein ID: WP_011205526.1
Location: 1438063..1439118 (1056 bp)
Type: Others
Protein ID: WP_011205524.1
Location: 1439115..1440884 (1770 bp)
Type: Others
Protein ID: WP_009972550.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BPS_RS244601430773..1430895+123WP_006027270.1hypothetical protein-
BPS_RS24465 (BPSS1052)1430895..1432688+1794WP_009971786.1replication endonuclease-
BPS_RS24470 (BPSS1053)1432704..1432970+267WP_009971787.1ogr/Delta-like zinc finger family protein-
BPS_RS24475 (BPSS1054)1432967..1433173+207WP_004532731.1ogr/Delta-like zinc finger family protein-
BPS_RS24480 (BPSS1055)1433263..1433916+654WP_004532770.1AAA family ATPase-
BPS_RS24485 (BPSS1056)1434150..1434272+123WP_009897078.1CopG family transcriptional regulator-
BPS_RS24490 (BPSS1057)1434375..1434908+534WP_004532793.1bacteriophage gp29 protein-
BPS_RS24495 (BPSS1058)1434905..1435642+738WP_011205520.1VRR-NUC domain-containing protein-
BPS_RS24500 (BPSS1059)1435657..1436772+1116WP_029670743.1DUF3396 domain-containing protein-
BPS_RS24505 (BPSS1060)1437364..1437660+297WP_024431052.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BPS_RS24510 (BPSS1061)1437663..1438019+357WP_009971793.1putative addiction module antidote proteinAntitoxin
BPS_RS24515 (BPSS1062)1438063..1439118-1056WP_011205524.1phage portal protein-
BPS_RS24520 (BPSS1063)1439115..1440884-1770WP_009972550.1terminase ATPase subunit family protein-
BPS_RS24525 (BPSS1064)1441028..1441837+810WP_011205526.1GPO family capsid scaffolding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--1424167..146212037953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10916.71 Da        Isoelectric Point: 9.9369

>T6106 WP_024431052.1 NC_006351:1437364-1437660 [Burkholderia pseudomallei K96243]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRREKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T6106 NC_006351:1437364-1437660 [Burkholderia pseudomallei K96243]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGAAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12527.38 Da        Isoelectric Point: 10.2187

>AT6106 WP_009971793.1 NC_006351:1437663-1438019 [Burkholderia pseudomallei K96243]
MKISELAEFDGSKYLKDEATIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT6106 NC_006351:1437663-1438019 [Burkholderia pseudomallei K96243]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGCAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T6105Burkholderia pseudomallei K96243

98.98

100

0.99

T10097Pseudomonas aeruginosa

46.316

96.939

0.449

T10169Acinetobacter baumannii

27.778

100

0.306
Showing 1 to 3 of 3 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT6105Burkholderia pseudomallei K96243

99.153

100

0.992

AT10097Pseudomonas aeruginosa

37.778

93.75

0.354
Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References

(1) Aaron Butt et al. (2013) Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiology Letters 338(1):86-94. [PubMed:23082999] experimental


experimental experimental literature