49221

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 61254..61909 Replicon chromosome
Accession NZ_CP009537
Organism Burkholderia pseudomallei K96243

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AQ15_RS00295 Protein ID WP_024431052.1
Coordinates 61254..61550 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AQ15_RS00300 Protein ID WP_009971793.1
Coordinates 61553..61909 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ15_RS00260 56594..56860 + 267 WP_009971787.1 ogr/Delta-like zinc finger family protein -
AQ15_RS00265 56857..57063 + 207 WP_004532731.1 ogr/Delta-like zinc finger family protein -
AQ15_RS00270 57153..57806 + 654 WP_004532770.1 AAA family ATPase -
AQ15_RS00275 58040..58162 + 123 WP_009897078.1 CopG family transcriptional regulator -
AQ15_RS00280 58265..58798 + 534 WP_004532793.1 bacteriophage gp29 protein -
AQ15_RS00285 58795..59532 + 738 WP_011205520.1 VRR-NUC domain-containing protein -
AQ15_RS00290 59547..60662 + 1116 WP_029670743.1 DUF3396 domain-containing protein -
AQ15_RS00295 61254..61550 + 297 WP_024431052.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AQ15_RS00300 61553..61909 + 357 WP_009971793.1 putative addiction module antidote protein Antitoxin
AQ15_RS00305 61953..63008 - 1056 WP_011205524.1 phage portal protein -
AQ15_RS00310 63005..64774 - 1770 WP_009972550.1 terminase ATPase subunit family protein -
AQ15_RS00315 64918..65727 + 810 WP_011205526.1 GPO family capsid scaffolding protein -
AQ15_RS00320 65761..66774 + 1014 WP_004532901.1 phage major capsid protein, P2 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 48057..86010 37953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10916.71 Da        Isoelectric Point: 9.9369

>T49221 WP_024431052.1 NZ_CP009537:61254-61550 [Burkholderia pseudomallei K96243]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRREKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T49221 NZ_CP009537:61254-61550 [Burkholderia pseudomallei K96243]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGAAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12527.38 Da        Isoelectric Point: 10.2187

>AT49221 WP_009971793.1 NZ_CP009537:61553-61909 [Burkholderia pseudomallei K96243]
MKISELAEFDGSKYLKDEATIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT49221 NZ_CP009537:61553-61909 [Burkholderia pseudomallei K96243]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGCAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References