44474

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1431962..1432617 Replicon chromosome
Accession NZ_AP028074
Organism Burkholderia pseudomallei strain GTC3P0050

Toxin (Protein)


Gene name relE Uniprot ID B1H687
Locus tag QUF22_RS24375 Protein ID WP_004532728.1
Coordinates 1431962..1432258 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag QUF22_RS24380 Protein ID WP_004202809.1
Coordinates 1432261..1432617 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUF22_RS24340 (GTC050_46750) 1427302..1427568 + 267 WP_004532697.1 ogr/Delta-like zinc finger family protein -
QUF22_RS24345 (GTC050_46760) 1427565..1427771 + 207 WP_004532731.1 ogr/Delta-like zinc finger family protein -
QUF22_RS24350 (GTC050_46770) 1427861..1428514 + 654 WP_004532770.1 AAA family ATPase -
QUF22_RS24355 (GTC050_46780) 1428589..1428870 + 282 WP_015985021.1 hypothetical protein -
QUF22_RS24360 (GTC050_46790) 1428973..1429506 + 534 WP_004532793.1 PAAR domain-containing protein -
QUF22_RS24365 (GTC050_46800) 1429503..1430240 + 738 WP_004532838.1 VRR-NUC domain-containing protein -
QUF22_RS24370 (GTC050_46810) 1430255..1431370 + 1116 WP_029670743.1 DUF3396 domain-containing protein -
QUF22_RS24375 1431962..1432258 + 297 WP_004532728.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUF22_RS24380 (GTC050_46830) 1432261..1432617 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
QUF22_RS24385 (GTC050_46840) 1432661..1433716 - 1056 WP_004199886.1 phage portal protein -
QUF22_RS24390 (GTC050_46850) 1433713..1435482 - 1770 WP_038757698.1 terminase ATPase subunit family protein -
QUF22_RS24395 (GTC050_46860) 1435626..1436435 + 810 WP_004532870.1 GPO family capsid scaffolding protein -
QUF22_RS24400 (GTC050_46870) 1436469..1437482 + 1014 WP_004532901.1 phage major capsid protein, P2 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1418660..1456475 37815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10876.71 Da        Isoelectric Point: 10.1723

>T44474 WP_004532728.1 NZ_AP028074:1431962-1432258 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFMRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T44474 NZ_AP028074:1431962-1432258 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTCGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATTGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCATGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGTGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT44474 WP_004202809.1 NZ_AP028074:1432261-1432617 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT44474 NZ_AP028074:1432261-1432617 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1H687

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References