Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/upstrm_HI1419-dnstrm_HI1420 |
Location | 350664..351319 | Replicon | chromosome |
Accession | NZ_CP009586 | ||
Organism | Burkholderia pseudomallei strain PHLS 112 |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | DP45_RS19075 | Protein ID | WP_024431052.1 |
Coordinates | 351023..351319 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | DP45_RS19070 | Protein ID | WP_009971793.1 |
Coordinates | 350664..351020 (-) | Length | 119 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DP45_RS19050 | 345799..346812 | - | 1014 | WP_009972548.1 | phage major capsid protein, P2 family | - |
DP45_RS19055 | 346846..347655 | - | 810 | WP_009972549.1 | GPO family capsid scaffolding protein | - |
DP45_RS19060 | 347799..349568 | + | 1770 | WP_009972550.1 | terminase ATPase subunit family protein | - |
DP45_RS19065 | 349565..350620 | + | 1056 | WP_011205524.1 | phage portal protein | - |
DP45_RS19070 | 350664..351020 | - | 357 | WP_009971793.1 | putative addiction module antidote protein | Antitoxin |
DP45_RS19075 | 351023..351319 | - | 297 | WP_024431052.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
DP45_RS19080 | 351911..353026 | - | 1116 | WP_029670743.1 | DUF3396 domain-containing protein | - |
DP45_RS19085 | 353041..353778 | - | 738 | WP_011205520.1 | VRR-NUC domain-containing protein | - |
DP45_RS19090 | 353775..354308 | - | 534 | WP_004532793.1 | bacteriophage gp29 protein | - |
DP45_RS19095 | 354411..354533 | - | 123 | WP_009897078.1 | CopG family transcriptional regulator | - |
DP45_RS19100 | 354767..355420 | - | 654 | WP_004532770.1 | AAA family ATPase | - |
DP45_RS19105 | 355510..355716 | - | 207 | WP_004532731.1 | ogr/Delta-like zinc finger family protein | - |
DP45_RS19110 | 355713..355979 | - | 267 | WP_009971787.1 | ogr/Delta-like zinc finger family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 326563..364516 | 37953 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 10916.71 Da Isoelectric Point: 9.9369
>T49297 WP_024431052.1 NZ_CP009586:c351319-351023 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRREKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRREKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED
Download Length: 297 bp
>T49297 NZ_CP009586:c351319-351023 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGAAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGAAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA
Antitoxin
Download Length: 119 a.a. Molecular weight: 12527.38 Da Isoelectric Point: 10.2187
>AT49297 WP_009971793.1 NZ_CP009586:c351020-350664 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEATIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA
MKISELAEFDGSKYLKDEATIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA
Download Length: 357 bp
>AT49297 NZ_CP009586:c351020-350664 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGCAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGCAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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