Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 350664..351319 Replicon chromosome
Accession NZ_CP009586
Organism Burkholderia pseudomallei strain PHLS 112

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DP45_RS19075 Protein ID WP_024431052.1
Coordinates 351023..351319 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DP45_RS19070 Protein ID WP_009971793.1
Coordinates 350664..351020 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DP45_RS19050 345799..346812 - 1014 WP_009972548.1 phage major capsid protein, P2 family -
DP45_RS19055 346846..347655 - 810 WP_009972549.1 GPO family capsid scaffolding protein -
DP45_RS19060 347799..349568 + 1770 WP_009972550.1 terminase ATPase subunit family protein -
DP45_RS19065 349565..350620 + 1056 WP_011205524.1 phage portal protein -
DP45_RS19070 350664..351020 - 357 WP_009971793.1 putative addiction module antidote protein Antitoxin
DP45_RS19075 351023..351319 - 297 WP_024431052.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DP45_RS19080 351911..353026 - 1116 WP_029670743.1 DUF3396 domain-containing protein -
DP45_RS19085 353041..353778 - 738 WP_011205520.1 VRR-NUC domain-containing protein -
DP45_RS19090 353775..354308 - 534 WP_004532793.1 bacteriophage gp29 protein -
DP45_RS19095 354411..354533 - 123 WP_009897078.1 CopG family transcriptional regulator -
DP45_RS19100 354767..355420 - 654 WP_004532770.1 AAA family ATPase -
DP45_RS19105 355510..355716 - 207 WP_004532731.1 ogr/Delta-like zinc finger family protein -
DP45_RS19110 355713..355979 - 267 WP_009971787.1 ogr/Delta-like zinc finger family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 326563..364516 37953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10916.71 Da        Isoelectric Point: 9.9369

>T49297 WP_024431052.1 NZ_CP009586:c351319-351023 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRREKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T49297 NZ_CP009586:c351319-351023 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGAAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12527.38 Da        Isoelectric Point: 10.2187

>AT49297 WP_009971793.1 NZ_CP009586:c351020-350664 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEATIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT49297 NZ_CP009586:c351020-350664 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGCAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References