44477

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1431874..1432529 Replicon chromosome
Accession NZ_AP028076
Organism Burkholderia pseudomallei strain GTC3P0054

Toxin (Protein)


Gene name relE Uniprot ID B1H687
Locus tag QUF23_RS24350 Protein ID WP_004532728.1
Coordinates 1431874..1432170 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag QUF23_RS24355 Protein ID WP_004202809.1
Coordinates 1432173..1432529 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUF23_RS24315 (GTC054_46670) 1427214..1427480 + 267 WP_004532697.1 ogr/Delta-like zinc finger family protein -
QUF23_RS24320 (GTC054_46680) 1427477..1427683 + 207 WP_004532731.1 ogr/Delta-like zinc finger family protein -
QUF23_RS24325 (GTC054_46690) 1427773..1428426 + 654 WP_004532770.1 AAA family ATPase -
QUF23_RS24330 (GTC054_46700) 1428501..1428782 + 282 WP_015985021.1 hypothetical protein -
QUF23_RS24335 (GTC054_46710) 1428885..1429418 + 534 WP_004532793.1 PAAR domain-containing protein -
QUF23_RS24340 (GTC054_46720) 1429415..1430152 + 738 WP_004532838.1 VRR-NUC domain-containing protein -
QUF23_RS24345 (GTC054_46730) 1430167..1431282 + 1116 WP_029670743.1 DUF3396 domain-containing protein -
QUF23_RS24350 1431874..1432170 + 297 WP_004532728.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUF23_RS24355 (GTC054_46750) 1432173..1432529 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
QUF23_RS24360 (GTC054_46760) 1432573..1433628 - 1056 WP_038737788.1 phage portal protein -
QUF23_RS24365 (GTC054_46770) 1433625..1435394 - 1770 WP_286272671.1 terminase ATPase subunit family protein -
QUF23_RS24370 (GTC054_46780) 1435538..1436347 + 810 WP_004532870.1 GPO family capsid scaffolding protein -
QUF23_RS24375 (GTC054_46790) 1436381..1437394 + 1014 WP_004532901.1 phage major capsid protein, P2 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1418572..1456631 38059


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10876.71 Da        Isoelectric Point: 10.1723

>T44477 WP_004532728.1 NZ_AP028076:1431874-1432170 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFMRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T44477 NZ_AP028076:1431874-1432170 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTCGACGGGCTTCGCGACCCGGTCGGTAGCGCGGCGATCAA
CCTGCGCATTGAGCGGGCAAAGCTTGGCAATCTCGGCCAATGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCATGCGACGCGGAAAAATTATCGTCGTGGTGTTGTGCGGTGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT44477 WP_004202809.1 NZ_AP028076:1432173-1432529 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT44477 NZ_AP028076:1432173-1432529 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1H687

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References