Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/upstrm_HI1419-dnstrm_HI1420 |
Location | 1091780..1092435 | Replicon | chromosome |
Accession | NZ_CP008912 | ||
Organism | Burkholderia pseudomallei HBPUB10134a |
Toxin (Protein)
Gene name | relE | Uniprot ID | - |
Locus tag | DR55_RS21990 | Protein ID | WP_024431052.1 |
Coordinates | 1092139..1092435 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | - |
Locus tag | DR55_RS21985 | Protein ID | WP_015985014.1 |
Coordinates | 1091780..1092136 (-) | Length | 119 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DR55_RS21965 | 1086915..1087928 | - | 1014 | WP_004531048.1 | phage major capsid protein, P2 family | - |
DR55_RS21970 | 1087962..1088771 | - | 810 | WP_004532870.1 | GPO family capsid scaffolding protein | - |
DR55_RS21975 | 1088915..1090684 | + | 1770 | WP_024431548.1 | terminase ATPase subunit family protein | - |
DR55_RS21980 | 1090681..1091736 | + | 1056 | WP_004556602.1 | phage portal protein | - |
DR55_RS21985 | 1091780..1092136 | - | 357 | WP_015985014.1 | putative addiction module antidote protein | Antitoxin |
DR55_RS21990 | 1092139..1092435 | - | 297 | WP_024431052.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
DR55_RS21995 | 1093027..1094142 | - | 1116 | WP_029670743.1 | DUF3396 domain-containing protein | - |
DR55_RS22000 | 1094157..1094894 | - | 738 | WP_011205520.1 | VRR-NUC domain-containing protein | - |
DR55_RS22005 | 1094891..1095424 | - | 534 | WP_004532793.1 | bacteriophage gp29 protein | - |
DR55_RS22010 | 1095527..1095649 | - | 123 | WP_009897078.1 | CopG family transcriptional regulator | - |
DR55_RS22015 | 1095883..1096536 | - | 654 | WP_004532770.1 | AAA family ATPase | - |
DR55_RS22020 | 1096626..1096832 | - | 207 | WP_004532731.1 | ogr/Delta-like zinc finger family protein | - |
DR55_RS22025 | 1096829..1097095 | - | 267 | WP_009971787.1 | ogr/Delta-like zinc finger family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 1066770..1105633 | 38863 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 10916.71 Da Isoelectric Point: 9.9369
>T47912 WP_024431052.1 NZ_CP008912:c1092435-1092139 [Burkholderia pseudomallei HBPUB10134a]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRREKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRREKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED
Download Length: 297 bp
>T47912 NZ_CP008912:c1092435-1092139 [Burkholderia pseudomallei HBPUB10134a]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGAAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGAAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA
Antitoxin
Download Length: 119 a.a. Molecular weight: 12575.37 Da Isoelectric Point: 9.9470
>AT47912 WP_015985014.1 NZ_CP008912:c1092136-1091780 [Burkholderia pseudomallei HBPUB10134a]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAESAPVPAPATTRARSRVRTAAHA
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAESAPVPAPATTRARSRVRTAAHA
Download Length: 357 bp
>AT47912 NZ_CP008912:c1092136-1091780 [Burkholderia pseudomallei HBPUB10134a]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAATACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAATCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAATACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAATCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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