Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1091780..1092435 Replicon chromosome
Accession NZ_CP008912
Organism Burkholderia pseudomallei HBPUB10134a

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DR55_RS21990 Protein ID WP_024431052.1
Coordinates 1092139..1092435 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DR55_RS21985 Protein ID WP_015985014.1
Coordinates 1091780..1092136 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR55_RS21965 1086915..1087928 - 1014 WP_004531048.1 phage major capsid protein, P2 family -
DR55_RS21970 1087962..1088771 - 810 WP_004532870.1 GPO family capsid scaffolding protein -
DR55_RS21975 1088915..1090684 + 1770 WP_024431548.1 terminase ATPase subunit family protein -
DR55_RS21980 1090681..1091736 + 1056 WP_004556602.1 phage portal protein -
DR55_RS21985 1091780..1092136 - 357 WP_015985014.1 putative addiction module antidote protein Antitoxin
DR55_RS21990 1092139..1092435 - 297 WP_024431052.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DR55_RS21995 1093027..1094142 - 1116 WP_029670743.1 DUF3396 domain-containing protein -
DR55_RS22000 1094157..1094894 - 738 WP_011205520.1 VRR-NUC domain-containing protein -
DR55_RS22005 1094891..1095424 - 534 WP_004532793.1 bacteriophage gp29 protein -
DR55_RS22010 1095527..1095649 - 123 WP_009897078.1 CopG family transcriptional regulator -
DR55_RS22015 1095883..1096536 - 654 WP_004532770.1 AAA family ATPase -
DR55_RS22020 1096626..1096832 - 207 WP_004532731.1 ogr/Delta-like zinc finger family protein -
DR55_RS22025 1096829..1097095 - 267 WP_009971787.1 ogr/Delta-like zinc finger family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1066770..1105633 38863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10916.71 Da        Isoelectric Point: 9.9369

>T47912 WP_024431052.1 NZ_CP008912:c1092435-1092139 [Burkholderia pseudomallei HBPUB10134a]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRREKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T47912 NZ_CP008912:c1092435-1092139 [Burkholderia pseudomallei HBPUB10134a]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTACTTCGTGCGACGCGAAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12575.37 Da        Isoelectric Point: 9.9470

>AT47912 WP_015985014.1 NZ_CP008912:c1092136-1091780 [Burkholderia pseudomallei HBPUB10134a]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAESAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT47912 NZ_CP008912:c1092136-1091780 [Burkholderia pseudomallei HBPUB10134a]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAATACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAATCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References