Detailed information of TA system TA006105

Experimentally validated

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Xre-RelE
• Location: 178503..179185
• Replicon: chromosome
• Accession: NC_006350
• Organism: Burkholderia pseudomallei K96243

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0F6LEW6
• Locus tag: BPS_RS00910
• Protein ID: WP_006027262.1
• Coordinates: 178862..179158 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q63YL3
• Locus tag: BPS_RS00905
• Protein ID: WP_004202809.1
• Coordinates: 178503..178859 (-)
• Length: 119 a.a.

Genomic Context

Location: 175638..177407 (1770 bp)
Type: Others
Protein ID: WP_011204765.1

Location: 177404..178459 (1056 bp)
Type: Others
Protein ID: WP_011204766.1

Location: 182072..182806 (735 bp)
Type: Others
Protein ID: WP_004190026.1

Location: 182900..183532 (633 bp)
Type: Others
Protein ID: WP_004189241.1

Location: 183552..184004 (453 bp)
Type: Others
Protein ID: WP_004189793.1

Location: 173641..174651 (1011 bp)
Type: Others
Protein ID: WP_011204764.1

Location: 174685..175494 (810 bp)
Type: Others
Protein ID: WP_004532870.1

Location: 178503..178859 (357 bp)
Type: Antitoxin
Protein ID: WP_004202809.1

Location: 178862..179158 (297 bp)
Type: Toxin
Protein ID: WP_006027262.1

Location: 179988..180551 (564 bp)
Type: Others
Protein ID: WP_038782825.1

Location: 180548..180904 (357 bp)
Type: Others
Protein ID: WP_162486661.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BPS_RS00885 (BPSL0170)	173641..174651	-	1011	WP_011204764.1	phage major capsid protein, P2 family	-
BPS_RS00890 (BPSL0171)	174685..175494	-	810	WP_004532870.1	GPO family capsid scaffolding protein	-
BPS_RS00895 (BPSL0172)	175638..177407	+	1770	WP_011204765.1	terminase ATPase subunit family protein	-
BPS_RS00900 (BPSL0173)	177404..178459	+	1056	WP_011204766.1	phage portal protein	-
BPS_RS00905 (BPSL0174)	178503..178859	-	357	WP_004202809.1	putative addiction module antidote protein	Antitoxin
BPS_RS00910 (BPSL0175)	178862..179158	-	297	WP_006027262.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BPS_RS00915 (BPSL0176)	179988..180551	-	564	WP_038782825.1	hypothetical protein	-
BPS_RS00920	180548..180904	-	357	WP_162486661.1	hypothetical protein	-
BPS_RS00925 (BPSL0177)	182072..182806	+	735	WP_004190026.1	7-cyano-7-deazaguanine synthase QueC	-
BPS_RS00930 (BPSL0178)	182900..183532	+	633	WP_004189241.1	7-carboxy-7-deazaguanine synthase	-
BPS_RS00935 (BPSL0179)	183552..184004	+	453	WP_004189793.1	6-carboxytetrahydropterin synthase QueD	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NZ_CP009538 Burkholderia pseudomallei K96243 Prophage TA049226 1521297..1574264 0.009 View NZ_CP018400 Burkholderia pseudomallei strain 2013746811 Prophage TA069903 2304972..2343865 0.001	inside	Prophage	-	-	146684..183532	36848

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-97)

Antitoxin

• Uncharacterized protein HI1420 (16-94)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10844.65 Da
• Isoelectric Point: 10.1723

>T6105 WP_006027262.1 NC_006350:c179158-178862 [Burkholderia pseudomallei K96243]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Nucleotide

• Length: 297 bp

>T6105 NC_006350:c179158-178862 [Burkholderia pseudomallei K96243]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 12585.41 Da
• Isoelectric Point: 9.9470

>AT6105 WP_004202809.1 NC_006350:c178859-178503 [Burkholderia pseudomallei K96243]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Nucleotide

• Length: 357 bp

>AT6105 NC_006350:c178859-178503 [Burkholderia pseudomallei K96243]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
T6106	Burkholderia pseudomallei K96243	98.98	100	0.99
T10097	Pseudomonas aeruginosa	47.368	96.939	0.459
T10169	Acinetobacter baumannii	27.778	100	0.306

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Multiple sequence alignment

Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
AT6106	Burkholderia pseudomallei K96243	99.153	100	0.992
AT10097	Pseudomonas aeruginosa	38.889	93.75	0.365

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Multiple sequence alignment

Structures

Toxin

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• AlphaFold DB: A0A0F6LEW6

Antitoxin

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• AlphaFold DB: A0A3N4G1D3

References

(1) Aaron Butt et al. (2013) Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiology Letters 338(1):86-94. [PubMed:23082999]


 experimental literature