69903

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2338836..2339491 Replicon chromosome
Accession NZ_CP018400
Organism Burkholderia pseudomallei strain 2013746811

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag BOC51_RS12370 Protein ID WP_006027262.1
Coordinates 2339195..2339491 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BOC51_RS12365 Protein ID WP_004202809.1
Coordinates 2338836..2339192 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOC51_RS12345 2333974..2334984 - 1011 WP_011204764.1 phage major capsid protein, P2 family -
BOC51_RS12350 2335018..2335827 - 810 WP_004532870.1 GPO family capsid scaffolding protein -
BOC51_RS12355 2335971..2337740 + 1770 WP_011204765.1 terminase ATPase subunit family protein -
BOC51_RS12360 2337737..2338792 + 1056 WP_011204766.1 phage portal protein -
BOC51_RS12365 2338836..2339192 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BOC51_RS12370 2339195..2339491 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BOC51_RS12375 2340321..2340881 - 561 WP_179093274.1 hypothetical protein -
BOC51_RS37655 2340881..2341237 - 357 WP_162486661.1 hypothetical protein -
BOC51_RS12385 2342405..2343139 + 735 WP_004190026.1 7-cyano-7-deazaguanine synthase QueC -
BOC51_RS12390 2343233..2343865 + 633 WP_004189241.1 7-carboxy-7-deazaguanine synthase -
BOC51_RS12395 2343885..2344337 + 453 WP_004189793.1 6-carboxytetrahydropterin synthase QueD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2304972..2343865 38893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T69903 WP_006027262.1 NZ_CP018400:c2339491-2339195 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T69903 NZ_CP018400:c2339491-2339195 [Burkholderia pseudomallei]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT69903 WP_004202809.1 NZ_CP018400:c2339192-2338836 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT69903 NZ_CP018400:c2339192-2338836 [Burkholderia pseudomallei]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References