Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1525671..1526326 Replicon chromosome
Accession NZ_CP009538
Organism Burkholderia pseudomallei K96243

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag AQ15_RS19715 Protein ID WP_006027262.1
Coordinates 1525671..1525967 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag AQ15_RS19720 Protein ID WP_004202809.1
Coordinates 1525970..1526326 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ15_RS19695 1520825..1521277 - 453 WP_004189793.1 6-carboxytetrahydropterin synthase QueD -
AQ15_RS19700 1521297..1521929 - 633 WP_004189241.1 7-carboxy-7-deazaguanine synthase -
AQ15_RS19705 1522023..1522757 - 735 WP_004190026.1 7-cyano-7-deazaguanine synthase QueC -
AQ15_RS40560 1523925..1524281 + 357 WP_162486661.1 hypothetical protein -
AQ15_RS19710 1524278..1524841 + 564 WP_038782825.1 hypothetical protein -
AQ15_RS19715 1525671..1525967 + 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AQ15_RS19720 1525970..1526326 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
AQ15_RS19725 1526370..1527425 - 1056 WP_011204766.1 phage portal protein -
AQ15_RS19730 1527422..1529191 - 1770 WP_011204765.1 terminase ATPase subunit family protein -
AQ15_RS19735 1529335..1530144 + 810 WP_004532870.1 GPO family capsid scaffolding protein -
AQ15_RS19740 1530178..1531188 + 1011 WP_011204764.1 phage major capsid protein, P2 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1521297..1574264 52967


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T49226 WP_006027262.1 NZ_CP009538:1525671-1525967 [Burkholderia pseudomallei K96243]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T49226 NZ_CP009538:1525671-1525967 [Burkholderia pseudomallei K96243]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT49226 WP_004202809.1 NZ_CP009538:1525970-1526326 [Burkholderia pseudomallei K96243]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT49226 NZ_CP009538:1525970-1526326 [Burkholderia pseudomallei K96243]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGGAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTCGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References