Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 14747..15404 Replicon plasmid pEc158
Accession NZ_KY887596
Organism Escherichia coli strain Ec158

Toxin (Protein)


Gene name higB Uniprot ID U3PDC3
Locus tag HTM98_RS00130 Protein ID WP_000270043.1
Coordinates 15054..15404 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HTM98_RS00125 Protein ID WP_000124640.1
Coordinates 14747..15049 (-) Length 101 a.a.

Genomic Context

HTM98_RS00075HTM98_RS00080HTM98_RS00085HTM98_RS00090HTM98_RS00095HTM98_RS00100HTM98_RS00105HTM98_RS00110HTM98_RS00115HTM98_RS00120HTM98_RS00135HTM98_RS00140HTM98_RS00145HTM98_RS00150HTM98_RS00155HTM98_RS00165HTM98_RS00170HTM98_RS00125HTM98_RS00130HTM98_RS00160
Location: 10372..10800 (429 bp)
Type: Others
Protein ID: WP_000591074.1
Location: 10857..11216 (360 bp)
Type: Others
Protein ID: WP_000422768.1
Location: 11216..11662 (447 bp)
Type: Others
Protein ID: WP_000919345.1
Location: 11659..12177 (519 bp)
Type: Others
Protein ID: WP_000210756.1
Location: 12177..12407 (231 bp)
Type: Others
Protein ID: WP_000972663.1
Location: 12394..13251 (858 bp)
Type: Others
Protein ID: WP_001167032.1
Location: 13277..13465 (189 bp)
Type: Others
Protein ID: WP_001270411.1
Location: 13482..14009 (528 bp)
Type: Others
Protein ID: WP_001236377.1
Location: 14067..14339 (273 bp)
Type: Others
Protein ID: WP_001043047.1
Location: 14427..14720 (294 bp)
Type: Others
Protein ID: WP_001239997.1
Location: 15567..16115 (549 bp)
Type: Others
Protein ID: WP_001061574.1
Location: 16289..16456 (168 bp)
Type: Others
Protein ID: WP_015059388.1
Location: 16456..16650 (195 bp)
Type: Others
Protein ID: WP_000343597.1
Location: 16661..17032 (372 bp)
Type: Others
Protein ID: WP_000516916.1
Location: 17025..17495 (471 bp)
Type: Others
Protein ID: WP_001281821.1
Location: 17942..18430 (489 bp)
Type: Others
Protein ID: WP_001273096.1
Location: 18433..18930 (498 bp)
Type: Others
Protein ID: WP_000062185.1
Location: 14747..15049 (303 bp)
Type: Antitoxin
Protein ID: WP_000124640.1
Location: 15054..15404 (351 bp)
Type: Toxin
Protein ID: WP_000270043.1
Location: 17510..17845 (336 bp)
Type: Others
Protein ID: WP_000683476.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HTM98_RS0007510372..10800+429WP_000591074.1hypothetical protein-
HTM98_RS0008010857..11216+360WP_000422768.1hypothetical protein-
HTM98_RS0008511216..11662+447WP_000919345.1Fe3+-siderophore ABC transporter permease-
HTM98_RS0009011659..12177+519WP_000210756.1nitrite reductase-
HTM98_RS0009512177..12407+231WP_000972663.1hypothetical protein-
HTM98_RS0010012394..13251+858WP_001167032.1hypothetical protein-
HTM98_RS0010513277..13465+189WP_001270411.1hypothetical protein-
HTM98_RS0011013482..14009+528WP_001236377.1thermonuclease family protein-
HTM98_RS0011514067..14339+273WP_001043047.1HU family DNA-binding protein-
HTM98_RS0012014427..14720+294WP_001239997.1chromosome segregation protein ParM-
HTM98_RS0012514747..15049-303WP_000124640.1XRE family transcriptional regulatorAntitoxin
HTM98_RS0013015054..15404-351WP_000270043.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HTM98_RS0013515567..16115+549WP_001061574.1transcriptional regulator-
HTM98_RS0014016289..16456+168WP_015059388.1hypothetical protein-
HTM98_RS0014516456..16650+195WP_000343597.1hypothetical protein-
HTM98_RS0015016661..17032+372WP_000516916.1hypothetical protein-
HTM98_RS0015517025..17495+471WP_001281821.1hypothetical protein-
HTM98_RS0016017510..17845-336WP_000683476.1hypothetical protein-
HTM98_RS0016517942..18430+489WP_001273096.1DUF1643 domain-containing protein-
HTM98_RS0017018433..18930+498WP_000062185.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideConjugative plasmidblaIMP-4 / catB3 / qacE / sul1 / mph(A) / aac(3)-IId / dfrA35 / blaTEM-1B-1..165169165169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Cro/C1-type helix-turn-helix domain

(33-79)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 11006.73 Da        Isoelectric Point: 7.2036

>T10063 WP_000270043.1 NZ_KY887596:c15404-15054 [Escherichia coli]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE

Download         Length: 351 bp

>T10063 NZ_KY887596:c15404-15054 [Escherichia coli]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11006.73 Da        Isoelectric Point: 7.2036

>AT10063 WP_000124640.1 NZ_KY887596:c15049-14747 [Escherichia coli]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV

Download         Length: 303 bp

>AT10063 NZ_KY887596:c15049-14747 [Escherichia coli]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT10169Acinetobacter baumannii

51

100

0.51

AT10050Mycobacterium tuberculosis H37Rv

33.333

99

0.33
Showing 1 to 2 of 2 rows

Multiple sequence alignment    




Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A7G8AFB9

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References

(1) Qin Qi et al. (2021) The higBA-Type Toxin-Antitoxin System in IncC Plasmids Is a Mobilizable Ciprofloxacin-Inducible System. MSphere 6(3):e0042421. [PubMed:34077263] experimental


experimental experimental literature