Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 140528..141185 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP066808 | ||
| Organism | Escherichia coli strain TCM3e1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | JGU77_RS25415 | Protein ID | WP_000270043.1 |
| Coordinates | 140528..140878 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | JGU77_RS25420 | Protein ID | WP_000124640.1 |
| Coordinates | 140883..141185 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JGU77_RS25380 | 137002..137499 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| JGU77_RS25385 | 137502..137990 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| JGU77_RS25390 | 138087..138422 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| JGU77_RS25395 | 138437..138907 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| JGU77_RS25400 | 138900..139271 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| JGU77_RS25405 | 139282..139476 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| JGU77_RS25410 | 139817..140365 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| JGU77_RS25415 | 140528..140878 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JGU77_RS25420 | 140883..141185 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| JGU77_RS25425 | 141212..141505 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| JGU77_RS25430 | 141593..141865 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| JGU77_RS25435 | 141923..142450 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| JGU77_RS25440 | 142467..142655 | - | 189 | WP_001270411.1 | hypothetical protein | - |
| JGU77_RS25445 | 142681..143538 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| JGU77_RS25450 | 143525..143755 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| JGU77_RS25455 | 143755..144273 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| JGU77_RS25460 | 144270..144716 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| JGU77_RS25465 | 144716..145075 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| JGU77_RS25470 | 145132..145560 | - | 429 | WP_072713905.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Conjugative plasmid | blaNDM-1 / sul1 / qacE / aadA2 / dfrA12 / mph(A) / blaSFO-1 / mph(E) / msr(E) | - | 1..191962 | 191962 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T185097 WP_000270043.1 NZ_CP066808:140528-140878 [Escherichia coli]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T185097 NZ_CP087993:1608985-1609272 [Xylella fastidiosa subsp. multiplex]
ATGGCTAAGTCCTATCGACTGACACCGCTGGCCGAGGCCGATCTTGAAGAAATCTGGTTCTACACATTCAGGCACTGGTC
GATAGAGCAGGCCGACAGCTACCACCGCAGCCTAGTTGCAGTTTTCGAGGGGCTGGCAGCAGGTACAAAGCAAGGCTGCC
CTTCTGTTTTGCCGGACTTCAATAAATACCTATGTGGTTCGCATGTAGTGTATTTCATGGATTACGCCGATCACTTGGAT
ATTATCCGCATCCTGCATCAGCGGCAGGATACCGAGCGGTACCTATAA
ATGGCTAAGTCCTATCGACTGACACCGCTGGCCGAGGCCGATCTTGAAGAAATCTGGTTCTACACATTCAGGCACTGGTC
GATAGAGCAGGCCGACAGCTACCACCGCAGCCTAGTTGCAGTTTTCGAGGGGCTGGCAGCAGGTACAAAGCAAGGCTGCC
CTTCTGTTTTGCCGGACTTCAATAAATACCTATGTGGTTCGCATGTAGTGTATTTCATGGATTACGCCGATCACTTGGAT
ATTATCCGCATCCTGCATCAGCGGCAGGATACCGAGCGGTACCTATAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT185097 WP_000124640.1 NZ_CP066808:140883-141185 [Escherichia coli]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT185097 NZ_CP087993:1608750-1608992 [Xylella fastidiosa subsp. multiplex]
ATGAGTCGAAACACATCCGTTGCCCTCGGGCCGCACTTCACCAGCTTTATTGATGCCCAAGTCCAGGGCGGTCGCTACGG
TACCGCCAGCGATGTTGTCAGGGCCGGTCTGCGGCTACTTGAGGAACACGAAACAAAGGTGAAGGCACTGCAAGATGCGC
TGAATGTTGGCCACCAATCCGGCGAGCCGCGCCCGTTCGACAGCGAGGTGTTTTTGAGCCGGATGCACACGCAGCATGGC
TAA
ATGAGTCGAAACACATCCGTTGCCCTCGGGCCGCACTTCACCAGCTTTATTGATGCCCAAGTCCAGGGCGGTCGCTACGG
TACCGCCAGCGATGTTGTCAGGGCCGGTCTGCGGCTACTTGAGGAACACGAAACAAAGGTGAAGGCACTGCAAGATGCGC
TGAATGTTGGCCACCAATCCGGCGAGCCGCGCCCGTTCGACAGCGAGGTGTTTTTGAGCCGGATGCACACGCAGCATGGC
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|