Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 13609..14266 | Replicon | plasmid pEC8-NDM-1 |
| Accession | NZ_CP060954 | ||
| Organism | Escherichia coli strain EC8 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | H9195_RS24820 | Protein ID | WP_000270043.1 |
| Coordinates | 13916..14266 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | H9195_RS24815 | Protein ID | WP_000124640.1 |
| Coordinates | 13609..13911 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9195_RS24765 (H9195_24520) | 9234..9662 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| H9195_RS24770 (H9195_24525) | 9719..10078 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| H9195_RS24775 (H9195_24530) | 10078..10524 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| H9195_RS24780 (H9195_24535) | 10521..11039 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| H9195_RS24785 (H9195_24540) | 11039..11269 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| H9195_RS24790 (H9195_24545) | 11256..12113 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| H9195_RS24795 (H9195_24550) | 12139..12327 | + | 189 | WP_001270411.1 | hypothetical protein | - |
| H9195_RS24800 (H9195_24555) | 12344..12871 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| H9195_RS24805 (H9195_24560) | 12929..13201 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| H9195_RS24810 (H9195_24565) | 13289..13582 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| H9195_RS24815 (H9195_24570) | 13609..13911 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| H9195_RS24820 (H9195_24575) | 13916..14266 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H9195_RS24825 (H9195_24580) | 14429..14977 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| H9195_RS24830 (H9195_24585) | 15318..15512 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| H9195_RS24835 (H9195_24590) | 15523..15894 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| H9195_RS24840 (H9195_24595) | 15887..16357 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| H9195_RS24845 (H9195_24600) | 16372..16707 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| H9195_RS24850 (H9195_24605) | 16804..17292 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| H9195_RS24855 (H9195_24610) | 17295..17792 | + | 498 | WP_000062185.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Conjugative plasmid | fosA3 / aac(6')-IIa / dfrA1 / aadA2 / qacE / sul1 / blaNDM-1 / catB3 / ARR-3 / armA / msr(E) / mph(E) / sul2 / blaTEM-1B | - | 1..168756 | 168756 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T171743 WP_000270043.1 NZ_CP060954:c14266-13916 [Escherichia coli]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T171743 NZ_CP078081:254218-254568 [Bacillus tropicus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT171743 WP_000124640.1 NZ_CP060954:c13911-13609 [Escherichia coli]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT171743 NZ_CP078081:253926-254213 [Bacillus tropicus]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|