Detailed information of TA system    

experimentalExperimentally validated    

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2266805..2267724 Replicon chromosome
Accession NC_000962
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name HigB2 Uniprot ID O53468
Locus tag Rv2022c Protein ID NP_216538.1
Coordinates 2267119..2267724 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID O53467
Locus tag Rv2021c Protein ID NP_216537.1
Coordinates 2266805..2267110 (-) Length 102 a.a.

Genomic Context

Rv2016Rv2017Rv2018Rv2019Rv2015cRv2021cRv2022cRv2023cRv2024cRv2025c
Location: 2263426..2264001 (576 bp)
Type: Others
Protein ID: NP_216532.1
Location: 2263998..2265038 (1041 bp)
Type: Others
Protein ID: NP_216533.1
Location: 2265280..2265999 (720 bp)
Type: Others
Protein ID: NP_216534.1
Location: 2265989..2266405 (417 bp)
Type: Others
Protein ID: NP_216535.1
Location: 2261816..2263072 (1257 bp)
Type: Others
Protein ID: NP_216531.1
Location: 2266805..2267110 (306 bp)
Type: Antitoxin
Protein ID: NP_216537.1
Location: 2267119..2267724 (606 bp)
Type: Toxin
Protein ID: NP_216538.1
Location: 2267749..2268108 (360 bp)
Type: Others
Protein ID: NP_216539.1
Location: 2268693..2270240 (1548 bp)
Type: Others
Protein ID: NP_216540.1
Location: 2270750..2271748 (999 bp)
Type: Others
Protein ID: NP_216541.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
Rv2015c2261816..2263072-1257NP_216531.1hypothetical protein-
Rv20162263426..2264001+576NP_216532.1hypothetical protein-
Rv20172263998..2265038+1041NP_216533.1transcriptional regulator-
Rv20182265280..2265999+720NP_216534.1hypothetical protein-
Rv20192265989..2266405+417NP_216535.1hypothetical protein-
Rv2021c2266805..2267110-306NP_216537.1transcriptional regulatorAntitoxin
Rv2022c2267119..2267724-606NP_216538.1hypothetical proteinToxin
Rv2023c2267749..2268108-360NP_216539.1hypothetical protein-
Rv2024c2268693..2270240-1548NP_216540.1hypothetical protein-
Rv2025c2270750..2271748-999NP_216541.1cation efflux system protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22744.96 Da        Isoelectric Point: 7.3073

>T10050 NP_216538.1 NC_000962:c2267724-2267119 [Mycobacterium tuberculosis H37Rv]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

>T10050 NC_000962:c2267724-2267119 [Mycobacterium tuberculosis H37Rv]
GTGAACGTTCCATGGGAGAACGCGCACGGCGGCGCACTGTACTGCCTCATACGTGGGGATGAATTCTCGGCCTGGCACAG
GCTACTGTTTCAACGGCCCGGGTGCGCAGAGTCCGTCCTCGCCTGCCGGCATTTCCTCGACGGTAGCCCCGTCGCCCGCT
GCTCTTACCCGGAGGAATATCACCCTTGTGTGATATCGCGTATCGCGCTACTCTGCGACTCTGTGGGGTGGACGGCGGAT
GTGGAGCGCATCTCCGCCTGGCTCAACGGCTTGGACCGAGAGACCTACGAATTGGTGTTCGCAGCTATCGAGGTTCTCGA
GGAAGAGGGCCCCGCACTTGGCTGTCCTCTGGTGGACACGGTGCGTGGGTCGCGCCACAAGAACATGAAGGAGCTGCGTC
CAGGATCACAAGGGCGGTCCGAGGTCCGCATTCTGTTCGCCTTCGACCCGGCGCGGCAGGCGATCATGCTGGCCGCCGGT
AACAAGGCCGGGCGGTGGACCCAGTGGTACGACGAGAAGATCAAAGCGGCCGATGAGATGTTTGCCGAACATCTCGCACA
GTTCGAGGACACGAAGCCAAAGAGGCGCAAGCGCAAGAAAGGGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT10050 NP_216537.1 NC_000962:c2267110-2266805 [Mycobacterium tuberculosis H37Rv]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp

>AT10050 NC_000962:c2267110-2266805 [Mycobacterium tuberculosis H37Rv]
ATGGCGATGACACTACGGGACATGGACGCCGTACGTCCCGTTAACCGGGAGGCGGTGGACCGGCACAAGGCACGAATGCG
CGATGAAGTGCGGGCATTCCGGCTCCGGGAGCTGCGCGCGGCTCAGTCACTCACCCAGGTCCAGGTGGCTGCGCTGGCGC
ACATCCGGCAGAGCCGGGTATCCAGCATCGAGAACGGCGACATCGGCTCCGCACAGGTCAACACACTGCGCAAATACGTG
TCCGCTCTTGGCGGAGAACTGGATATCACCGTCCGCCTGGGAGATGAGACATTCACCCTGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
T127Mycobacterium tuberculosis H37Rv

50.505

86.842

0.439

T10169Acinetobacter baumannii

44.348

97.458

0.432

T10063Escherichia coli strain Ec158

33.333

99

0.33
Showing 1 to 3 of 3 rows

Multiple sequence alignment    


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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
AT127Mycobacterium tuberculosis H37Rv

42.991

100

0.455

AT10169Acinetobacter baumannii

34.375

96

0.33

AT10063Escherichia coli strain Ec158

33.333

99

0.33

AT10106Xenorhabdus nematophila ATCC 19061

42.857

75.904

0.325
Showing 1 to 4 of 4 rows

Multiple sequence alignment    




Structures

Toxin

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Source
ID
Structure
AlphaFold DBO53468

Antitoxin

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Source
ID
Structure
PDB7EWD
PDB7EWC
PDB7EWE
AlphaFold DBO53467

References

(1) William Richardson et al. (2021) Chasing the structural diversity of the transcription regulator Mycobacterium tuberculosis HigA2. IUCrJ 8(Pt 5):823-832. [PubMed:34584743] 3D_structure


3D_structure protein structure literature