Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2186..2774 Replicon plasmid pAB120
Accession NZ_CP031446
Organism Acinetobacter baumannii strain MDR-UNC

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag DYB08_RS20055 Protein ID WP_000438826.1
Coordinates 2186..2473 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag DYB08_RS20060 Protein ID WP_001983304.1
Coordinates 2460..2774 (+) Length 105 a.a.

Genomic Context

DYB08_RS20045DYB08_RS20055DYB08_RS20060DYB08_RS20065DYB08_RS20070DYB08_RS20050DYB08_RS20075DYB08_RS20080DYB08_RS20085
Location: 815..1006 (192 bp)
Type: Others
Protein ID: WP_000032259.1
Location: 2186..2473 (288 bp)
Type: Toxin
Protein ID: WP_000438826.1
Location: 2460..2774 (315 bp)
Type: Antitoxin
Protein ID: WP_001983304.1
Location: 2902..5313 (2412 bp)
Type: Others
Protein ID: WP_000932953.1
Location: 5618..6079 (462 bp)
Type: Others
Protein ID: WP_000761346.1
Location: 1050..1877 (828 bp)
Type: Others
Protein ID: WP_000713530.1
Location: 6405..6614 (210 bp)
Type: Others
Protein ID: WP_000069473.1
Location: 6607..6909 (303 bp)
Type: Others
Protein ID: WP_001140622.1
Location: 6902..7258 (357 bp)
Type: Others
Protein ID: WP_000269902.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DYB08_RS20045815..1006+192WP_000032259.1hypothetical protein-
DYB08_RS200501050..1877-828WP_000713530.1OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72-
DYB08_RS200552186..2473+288WP_000438826.1BrnT family toxinToxin
DYB08_RS200602460..2774+315WP_001983304.1BrnA antitoxin family proteinAntitoxin
DYB08_RS200652902..5313+2412WP_000932953.1TonB-dependent receptor ZnuD2-
DYB08_RS200705618..6079+462WP_000761346.1DIP1984 family protein-
DYB08_RS200756405..6614-210WP_000069473.1hypothetical protein-
DYB08_RS200806607..6909-303WP_001140622.1XRE family transcriptional regulator-
DYB08_RS200856902..7258-357WP_000269902.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideNon-Mobilizable plasmidblaOXA-72-1..1087910879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T109195 WP_000438826.1 NZ_CP031446:2186-2473 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T109195 NZ_CP031446:2186-2473 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT109195 WP_001983304.1 NZ_CP031446:2460-2774 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT109195 NZ_CP031446:2460-2774 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3G6Z3M6

Antitoxin

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Source
ID
Structure
AlphaFold DBN9M5I3

References