206471

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 4012..4600 Replicon plasmid unnamed1
Accession NZ_CP076737
Organism Acinetobacter baumannii strain X4-201

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag KRO90_RS19220 Protein ID WP_000438826.1
Coordinates 4012..4299 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag KRO90_RS19225 Protein ID WP_001983304.1
Coordinates 4286..4600 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRO90_RS19200 (KRO90_19070) 1012..1962 + 951 WP_001205343.1 replication initiation protein RepM -
KRO90_RS19205 (KRO90_19075) 1955..2530 + 576 WP_279482303.1 plasmid replication DNA-binding protein -
KRO90_RS19210 (KRO90_19080) 2550..2693 + 144 WP_001125246.1 hypothetical protein -
KRO90_RS19215 (KRO90_19085) 2876..3703 - 828 WP_279482305.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase -
KRO90_RS19220 (KRO90_19090) 4012..4299 + 288 WP_000438826.1 BrnT family toxin Toxin
KRO90_RS19225 (KRO90_19095) 4286..4600 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
KRO90_RS19230 (KRO90_19100) 4728..7139 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
KRO90_RS19235 (KRO90_19105) 7444..7905 + 462 WP_000761346.1 DIP1984 family protein -
KRO90_RS19240 (KRO90_19110) 8228..8401 - 174 WP_001282484.1 hypothetical protein -
KRO90_RS19245 (KRO90_19115) 8401..8772 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid blaOXA-72 - 1..8970 8970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T206471 WP_000438826.1 NZ_CP076737:4012-4299 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T206471 NZ_CP102438:333781-334149 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCATGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTATGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT206471 WP_001983304.1 NZ_CP076737:4286-4600 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT206471 NZ_CP102438:333563-333784 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References