225356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 10646..11297 Replicon plasmid p2OC043
Accession NZ_CP087323
Organism Acinetobacter baumannii strain OC043

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LO002_RS19395 Protein ID WP_000269902.1
Coordinates 10646..11002 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LO002_RS19400 Protein ID WP_001140622.1
Coordinates 10995..11297 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO002_RS19370 6019..6210 - 192 WP_000032259.1 hypothetical protein -
LO002_RS19375 7346..8296 + 951 WP_001205343.1 replication initiation protein RepM -
LO002_RS19380 8289..8864 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
LO002_RS19385 8884..9027 + 144 WP_001125246.1 hypothetical protein -
LO002_RS19390 9210..10037 - 828 WP_000713530.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72 -
LO002_RS19395 10646..11002 + 357 WP_000269902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO002_RS19400 10995..11297 + 303 WP_001140622.1 XRE family transcriptional regulator Antitoxin
LO002_RS19405 11290..11499 + 210 WP_000069473.1 hypothetical protein -
LO002_RS19410 11825..12286 - 462 WP_000761346.1 DIP1984 family protein -
LO002_RS19415 12591..15002 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
LO002_RS19420 15130..15444 - 315 WP_001983304.1 BrnA antitoxin family protein -
LO002_RS19425 15431..15718 - 288 WP_000438826.1 BrnT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid blaOXA-72 - 1..15932 15932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13487.44 Da        Isoelectric Point: 6.4631

>T225356 WP_000269902.1 NZ_CP087323:10646-11002 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

>T225356 NZ_CP121138:126990-127472 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11178.98 Da        Isoelectric Point: 6.7282

>AT225356 WP_001140622.1 NZ_CP087323:10995-11297 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT225356 NZ_CP121138:126736-127002 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References