Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 10646..11297 Replicon plasmid p2OC043
Accession NZ_CP087323
Organism Acinetobacter baumannii strain OC043

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LO002_RS19395 Protein ID WP_000269902.1
Coordinates 10646..11002 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LO002_RS19400 Protein ID WP_001140622.1
Coordinates 10995..11297 (+) Length 101 a.a.

Genomic Context

LO002_RS19375LO002_RS19380LO002_RS19385LO002_RS19395LO002_RS19400LO002_RS19405LO002_RS19370LO002_RS19390LO002_RS19410LO002_RS19415LO002_RS19420LO002_RS19425
Location: 7346..8296 (951 bp)
Type: Others
Protein ID: WP_001205343.1
Location: 8289..8864 (576 bp)
Type: Others
Protein ID: WP_001096616.1
Location: 8884..9027 (144 bp)
Type: Others
Protein ID: WP_001125246.1
Location: 10646..11002 (357 bp)
Type: Toxin
Protein ID: WP_000269902.1
Location: 10995..11297 (303 bp)
Type: Antitoxin
Protein ID: WP_001140622.1
Location: 11290..11499 (210 bp)
Type: Others
Protein ID: WP_000069473.1
Location: 6019..6210 (192 bp)
Type: Others
Protein ID: WP_000032259.1
Location: 9210..10037 (828 bp)
Type: Others
Protein ID: WP_000713530.1
Location: 11825..12286 (462 bp)
Type: Others
Protein ID: WP_000761346.1
Location: 12591..15002 (2412 bp)
Type: Others
Protein ID: WP_000932953.1
Location: 15130..15444 (315 bp)
Type: Others
Protein ID: WP_001983304.1
Location: 15431..15718 (288 bp)
Type: Others
Protein ID: WP_000438826.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LO002_RS193706019..6210-192WP_000032259.1hypothetical protein-
LO002_RS193757346..8296+951WP_001205343.1replication initiation protein RepM-
LO002_RS193808289..8864+576WP_001096616.1plasmid replication DNA-binding protein-
LO002_RS193858884..9027+144WP_001125246.1hypothetical protein-
LO002_RS193909210..10037-828WP_000713530.1OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72-
LO002_RS1939510646..11002+357WP_000269902.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LO002_RS1940010995..11297+303WP_001140622.1XRE family transcriptional regulatorAntitoxin
LO002_RS1940511290..11499+210WP_000069473.1hypothetical protein-
LO002_RS1941011825..12286-462WP_000761346.1DIP1984 family protein-
LO002_RS1941512591..15002-2412WP_000932953.1TonB-dependent receptor ZnuD2-
LO002_RS1942015130..15444-315WP_001983304.1BrnA antitoxin family protein-
LO002_RS1942515431..15718-288WP_000438826.1BrnT family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideNon-Mobilizable plasmidblaOXA-72-1..1593215932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13487.44 Da        Isoelectric Point: 6.4631

>T225356 WP_000269902.1 NZ_CP087323:10646-11002 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG

Download         Length: 357 bp

>T225356 NZ_CP121138:126990-127472 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11178.98 Da        Isoelectric Point: 6.7282

>AT225356 WP_001140622.1 NZ_CP087323:10995-11297 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT225356 NZ_CP121138:126736-127002 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References