Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 4200..4788 Replicon plasmid unnamed1
Accession NZ_CP074696
Organism Acinetobacter baumannii strain X4-107

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag IS508_RS19195 Protein ID WP_000438826.1
Coordinates 4200..4487 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag IS508_RS19200 Protein ID WP_001983304.1
Coordinates 4474..4788 (+) Length 105 a.a.

Genomic Context

IS508_RS19175IS508_RS19180IS508_RS19185IS508_RS19195IS508_RS19200IS508_RS19205IS508_RS19210IS508_RS19190IS508_RS19215IS508_RS19220
Location: 1200..2150 (951 bp)
Type: Others
Protein ID: WP_001205343.1
Location: 2143..2718 (576 bp)
Type: Others
Protein ID: WP_001096616.1
Location: 2738..2881 (144 bp)
Type: Others
Protein ID: WP_001125246.1
Location: 4200..4487 (288 bp)
Type: Toxin
Protein ID: WP_000438826.1
Location: 4474..4788 (315 bp)
Type: Antitoxin
Protein ID: WP_001983304.1
Location: 4916..7327 (2412 bp)
Type: Others
Protein ID: WP_000932953.1
Location: 7632..8093 (462 bp)
Type: Others
Protein ID: WP_000761346.1
Location: 3064..3891 (828 bp)
Type: Others
Protein ID: WP_000713530.1
Location: 8416..8589 (174 bp)
Type: Others
Protein ID: WP_001282484.1
Location: 8589..8960 (372 bp)
Type: Others
Protein ID: WP_000504218.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IS508_RS191751200..2150+951WP_001205343.1replication initiation protein RepM-
IS508_RS191802143..2718+576WP_001096616.1plasmid replication DNA-binding protein-
IS508_RS191852738..2881+144WP_001125246.1hypothetical protein-
IS508_RS191903064..3891-828WP_000713530.1OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72-
IS508_RS191954200..4487+288WP_000438826.1BrnT family toxinToxin
IS508_RS192004474..4788+315WP_001983304.1BrnA antitoxin family proteinAntitoxin
IS508_RS192054916..7327+2412WP_000932953.1TonB-dependent receptor ZnuD2-
IS508_RS192107632..8093+462WP_000761346.1DIP1984 family protein-
IS508_RS192158416..8589-174WP_001282484.1hypothetical protein-
IS508_RS192208589..8960-372WP_000504218.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideNon-Mobilizable plasmidblaOXA-72-1..89618961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T202661 WP_000438826.1 NZ_CP074696:4200-4487 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T202661 NZ_CP099576:c2270806-2270702 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT202661 WP_001983304.1 NZ_CP074696:4474-4788 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT202661 NZ_CP099576:2270608-2270646 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3G6Z3M6

Antitoxin

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Source
ID
Structure
AlphaFold DBN9M5I3

References