202661

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 4200..4788 Replicon plasmid unnamed1
Accession NZ_CP074696
Organism Acinetobacter baumannii strain X4-107

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag IS508_RS19195 Protein ID WP_000438826.1
Coordinates 4200..4487 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag IS508_RS19200 Protein ID WP_001983304.1
Coordinates 4474..4788 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS508_RS19175 1200..2150 + 951 WP_001205343.1 replication initiation protein RepM -
IS508_RS19180 2143..2718 + 576 WP_001096616.1 plasmid replication DNA-binding protein -
IS508_RS19185 2738..2881 + 144 WP_001125246.1 hypothetical protein -
IS508_RS19190 3064..3891 - 828 WP_000713530.1 OXA-24 family carbapenem-hydrolyzing class D beta-lactamase OXA-72 -
IS508_RS19195 4200..4487 + 288 WP_000438826.1 BrnT family toxin Toxin
IS508_RS19200 4474..4788 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
IS508_RS19205 4916..7327 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
IS508_RS19210 7632..8093 + 462 WP_000761346.1 DIP1984 family protein -
IS508_RS19215 8416..8589 - 174 WP_001282484.1 hypothetical protein -
IS508_RS19220 8589..8960 - 372 WP_000504218.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid blaOXA-72 - 1..8961 8961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T202661 WP_000438826.1 NZ_CP074696:4200-4487 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T202661 NZ_CP099576:c2270806-2270702 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT202661 WP_001983304.1 NZ_CP074696:4474-4788 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT202661 NZ_CP099576:2270608-2270646 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References