Detailed information NTG0098845

Bioinformatically predicted

Overview

• Name: comX/comX2
• Type: Regulator
• Locus tag: R8568_RS09540
• Genome accession: NZ_AP026931
• Coordinates: 1861005..1861484 (-)
• Length: 159 a.a.
• NCBI ID: WP_000588866.1
• Uniprot ID: A0A6C7J1A1
• Organism: Streptococcus pneumoniae strain PZ900701541
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1856005..1866484

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8568_RS09540 (PC1520_18580)	comX/comX2	1861005..1861484 (-)	480	WP_000588866.1	sigma-70 family RNA polymerase sigma factor	Regulator
R8568_RS09545 (PC1520_18590)	nusG	1861606..1862142 (-)	537	WP_000376736.1	transcription termination/antitermination protein NusG	-
R8568_RS09550 (PC1520_18600)	secE	1862197..1862373 (-)	177	WP_001210988.1	preprotein translocase subunit SecE	-
R8568_RS09555 (PC1520_18610)	rpmG	1862383..1862535 (-)	153	WP_001809375.1	50S ribosomal protein L33	-
R8568_RS09560 (PC1520_18620)	pbp2a	1862588..1864783 (-)	2196	WP_000762606.1	penicillin-binding protein PBP2A	-
R8568_RS09565 (PC1520_18630)	-	1864870..1865745 (+)	876	WP_076750265.1	RluA family pseudouridine synthase	-

Sequence

Protein

• Length: 159 a.a.
• Molecular weight: 19845.46 Da
• Isoelectric Point: 7.3797

>NTDB_id=98845 R8568_RS09540 WP_000588866.1 1861005..1861484(-) (comX/comX2) [Streptococcus pneumoniae strain PZ900701541]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISREEGLADDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGELSHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

Nucleotide

• Length: 480 bp

>NTDB_id=98845 R8568_RS09540 WP_000588866.1 1861005..1861484(-) (comX/comX2) [Streptococcus pneumoniae strain PZ900701541]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTGTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGACCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGCAGACGATATTCCAC
GTTTAAGGAAATATTTCAAAACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAGCAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGTGAGCTCAGTCATCGTATAAGTGAGGGAGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGTGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCACTAG

Domains

No domain identified.

3D structure

• AlphaFold DB: A0A6C7J1A1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/comX2	Streptococcus pneumoniae Rx1	98.742	100	0.987
comX/comX1	Streptococcus pneumoniae Rx1	98.742	100	0.987
comX/comX2	Streptococcus pneumoniae D39	98.742	100	0.987
comX/comX1	Streptococcus pneumoniae D39	98.742	100	0.987
comX/comX2	Streptococcus pneumoniae R6	98.742	100	0.987
comX/comX1	Streptococcus pneumoniae R6	98.742	100	0.987
comX/comX2	Streptococcus pneumoniae TIGR4	98.113	100	0.981
comX/comX1	Streptococcus pneumoniae TIGR4	98.113	100	0.981
comX/sigX/comX1/sigX1	Streptococcus mitis NCTC 12261	91.195	100	0.912
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	91.195	100	0.912
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	89.308	100	0.893
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	89.241	99.371	0.887
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	48.077	98.113	0.472
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	48.077	98.113	0.472
comX/sigX	Streptococcus suis D9	45.695	94.969	0.434
comX/sigX	Streptococcus suis isolate S10	45.695	94.969	0.434
comX/sigX	Streptococcus suis P1/7	45.695	94.969	0.434
comX/sigX	Streptococcus mutans UA159	45.333	94.34	0.428
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	40	94.34	0.377
comX	Streptococcus sobrinus strain NIDR 6715-7	38.926	93.711	0.365