Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   R4711_RS06570 Genome accession   NZ_CP137107
Coordinates   1301545..1302486 (+) Length   313 a.a.
NCBI ID   WP_000249550.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 15H4024     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1296545..1307486
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4711_RS06550 - 1296611..1298428 (+) 1818 WP_001220850.1 acyltransferase family protein -
  R4711_RS06555 nagA 1298581..1299732 (+) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  R4711_RS06560 - 1299895..1300953 (+) 1059 WP_000649468.1 zinc-dependent alcohol dehydrogenase family protein -
  R4711_RS06565 - 1301104..1301469 (+) 366 WP_000286415.1 DUF1033 family protein -
  R4711_RS06570 comGA/cglA/cilD 1301545..1302486 (+) 942 WP_000249550.1 competence type IV pilus ATPase ComGA Machinery gene
  R4711_RS06575 comGB/cglB 1302434..1303450 (+) 1017 WP_077141332.1 competence type IV pilus assembly protein ComGB Machinery gene
  R4711_RS06580 comGC/cglC 1303452..1303778 (+) 327 WP_000738623.1 comG operon protein ComGC Machinery gene
  R4711_RS06585 comGD/cglD 1303771..1304175 (+) 405 WP_000588002.1 competence type IV pilus minor pilin ComGD Machinery gene
  R4711_RS06590 comGE/cglE 1304138..1304440 (+) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  R4711_RS06595 comGF/cglF 1304403..1304864 (+) 462 WP_000250529.1 competence type IV pilus minor pilin ComGF Machinery gene
  R4711_RS06600 comGG/cglG 1304842..1305255 (+) 414 WP_000265617.1 competence type IV pilus minor pilin ComGG Machinery gene
  R4711_RS06605 - 1305392..1305979 (+) 588 Protein_1291 class I SAM-dependent methyltransferase -
  R4711_RS06610 comYH 1306040..1306993 (+) 954 WP_000345086.1 class I SAM-dependent methyltransferase Machinery gene

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35516.43 Da        Isoelectric Point: 6.0083

>NTDB_id=895642 R4711_RS06570 WP_000249550.1 1301545..1302486(+) (comGA/cglA/cilD) [Streptococcus pneumoniae strain 15H4024]
MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKIASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFASRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=895642 R4711_RS06570 WP_000249550.1 1301545..1302486(+) (comGA/cglA/cilD) [Streptococcus pneumoniae strain 15H4024]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCGGCTCGGAAAAAAGGGGCGCAAGACATTTATTTTGTCCCTAAGTT
AGATGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATAGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAAAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAGCAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae D39

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae R6

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

99.361

100

0.994
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

96.486

100

0.965
  comYA Streptococcus gordonii str. Challis substr. CH1

78.387

99.042

0.776
  comYA Streptococcus mutans UA159

66.238

99.361

0.658
  comYA Streptococcus mutans UA140

66.238

99.361

0.658
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.903

99.042

0.623
  comGA Lactococcus lactis subsp. cremoris KW2

55.128

99.681

0.55
  comGA Latilactobacillus sakei subsp. sakei 23K

41.912

86.901

0.364