Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   OS912_RS05375 Genome accession   NZ_CP113266
Coordinates   1047000..1047941 (-) Length   313 a.a.
NCBI ID   WP_000249550.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain BC1     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1042000..1052941
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OS912_RS05335 (OS912_05340) comYH 1042496..1043449 (-) 954 WP_050212403.1 class I SAM-dependent methyltransferase Machinery gene
  OS912_RS05340 (OS912_05345) - 1043510..1044097 (-) 588 Protein_1034 class I SAM-dependent methyltransferase -
  OS912_RS05345 (OS912_05350) comGG/cglG 1044234..1044644 (-) 411 WP_000265621.1 competence type IV pilus minor pilin ComGG Machinery gene
  OS912_RS05350 (OS912_05355) comGF/cglF 1044622..1045083 (-) 462 WP_268233038.1 competence type IV pilus minor pilin ComGF Machinery gene
  OS912_RS05355 (OS912_05360) comGE/cglE 1045046..1045348 (-) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  OS912_RS05360 (OS912_05365) comGD/cglD 1045311..1045715 (-) 405 WP_000588013.1 competence type IV pilus minor pilin ComGD Machinery gene
  OS912_RS05365 (OS912_05370) comGC/cglC 1045708..1046034 (-) 327 WP_000738626.1 comG operon protein ComGC Machinery gene
  OS912_RS05370 (OS912_05375) comGB/cglB 1046036..1047052 (-) 1017 WP_268233044.1 competence type IV pilus assembly protein ComGB Machinery gene
  OS912_RS05375 (OS912_05380) comGA/cglA/cilD 1047000..1047941 (-) 942 WP_000249550.1 competence type IV pilus ATPase ComGA Machinery gene
  OS912_RS05380 (OS912_05385) - 1048017..1048382 (-) 366 WP_000286415.1 DUF1033 family protein -
  OS912_RS05385 (OS912_05390) - 1048533..1049591 (-) 1059 WP_000649466.1 zinc-dependent alcohol dehydrogenase family protein -
  OS912_RS05390 (OS912_05395) nagA 1049754..1050905 (-) 1152 WP_001134459.1 N-acetylglucosamine-6-phosphate deacetylase -
  OS912_RS05395 (OS912_05400) - 1051058..1052875 (-) 1818 WP_001220843.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35516.43 Da        Isoelectric Point: 6.0083

>NTDB_id=761418 OS912_RS05375 WP_000249550.1 1047000..1047941(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain BC1]
MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKIASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFASRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=761418 OS912_RS05375 WP_000249550.1 1047000..1047941(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain BC1]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCGGCTCGGAAAAAAGGGGCGCAAGACATTTATTTTGTCCCCAAGTT
AGATGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATAGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAGCAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae D39

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae R6

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

99.361

100

0.994
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

96.486

100

0.965
  comYA Streptococcus gordonii str. Challis substr. CH1

78.387

99.042

0.776
  comYA Streptococcus mutans UA159

66.238

99.361

0.658
  comYA Streptococcus mutans UA140

66.238

99.361

0.658
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.903

99.042

0.623
  comGA Lactococcus lactis subsp. cremoris KW2

55.128

99.681

0.55
  comGA Latilactobacillus sakei subsp. sakei 23K

41.912

86.901

0.364