Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   SR187_RS00790 Genome accession   NZ_AP018400
Coordinates   123551..124501 (+) Length   316 a.a.
NCBI ID   WP_120171204.1    Uniprot ID   A0A2Z5TMM2
Organism   Streptococcus ruminantium strain GUT-187     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 118551..129501
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SR187_RS00780 (SR187_0805) - 122033..122401 (+) 369 WP_120171203.1 DUF1033 family protein -
  SR187_RS00785 (SR187_0810) - 122439..123389 (-) 951 WP_024532257.1 S66 peptidase family protein -
  SR187_RS00790 (SR187_0815) comYA 123551..124501 (+) 951 WP_120171204.1 competence type IV pilus ATPase ComGA Machinery gene
  SR187_RS00795 (SR187_0820) comYB 124422..125453 (+) 1032 WP_120171205.1 competence type IV pilus assembly protein ComGB Machinery gene
  SR187_RS00800 (SR187_0825) comYC 125450..125731 (+) 282 WP_024532254.1 competence type IV pilus major pilin ComGC Machinery gene
  SR187_RS00805 (SR187_0830) comGD 125718..126131 (+) 414 WP_024532253.1 competence type IV pilus minor pilin ComGD -
  SR187_RS00810 (SR187_0835) comYE 126103..126396 (+) 294 WP_120172446.1 competence type IV pilus minor pilin ComGE Machinery gene
  SR187_RS00815 (SR187_0840) comGF/cglF 126383..126817 (+) 435 WP_120171206.1 competence type IV pilus minor pilin ComGF Machinery gene
  SR187_RS00820 (SR187_0845) comGG 126795..127208 (+) 414 WP_120171207.1 competence type IV pilus minor pilin ComGG -
  SR187_RS00825 (SR187_0850) comYH 127213..128166 (+) 954 WP_120171208.1 class I SAM-dependent methyltransferase Machinery gene
  SR187_RS00830 (SR187_0855) - 128216..129403 (+) 1188 WP_120171209.1 acetate kinase -

Sequence

Protein


Download         Length: 316 a.a.        Molecular weight: 35633.55 Da        Isoelectric Point: 6.3989

>NTDB_id=69427 SR187_RS00790 WP_120171204.1 123551..124501(+) (comYA) [Streptococcus ruminantium strain GUT-187]
MIQEKARQMVEQAVLARVSDLYLVPRGESYQLYHRIMDERVFLQELNEEEVTAIISHFKFLAGLNVGEKRRSQQGSCDYN
YGSGQISLRLSTVGDYRGKESLVIRLLYDNDKELKFWFEAAERIAREIKGRGLYLFSGPVGSGKTTLMYHLARLKFPDKQ
ILTIEDPVEIKQEDMLQLQLNEAIGATYDNLIKLSLRHRPDLLIIGEIRDAETARAVIRASLTGATVFSTVHARSISGVY
ARMLELGVSTEELNNALQGIAYQRLIGGGGVVDFAKENFQNHSADQWNQQIDSLFAAGYISHRQAETEKIVFGSPA

Nucleotide


Download         Length: 951 bp        

>NTDB_id=69427 SR187_RS00790 WP_120171204.1 123551..124501(+) (comYA) [Streptococcus ruminantium strain GUT-187]
ATGATTCAAGAAAAAGCAAGACAGATGGTGGAACAAGCAGTGCTTGCTAGGGTTAGCGACCTTTATTTGGTTCCGCGAGG
GGAGTCCTATCAGCTCTATCATCGGATTATGGATGAACGAGTATTTTTGCAGGAATTGAATGAAGAAGAAGTGACAGCCA
TCATCAGTCATTTCAAGTTTTTGGCTGGTTTGAATGTCGGTGAAAAGCGTCGCAGTCAGCAAGGTTCTTGTGATTATAAT
TATGGTTCAGGGCAGATCTCCCTCCGCTTGTCCACTGTTGGTGATTACCGAGGTAAGGAGAGTTTGGTGATTCGATTGCT
GTACGATAATGATAAGGAACTCAAGTTTTGGTTTGAGGCAGCAGAGCGGATTGCTAGGGAAATCAAGGGGCGAGGACTCT
ACCTTTTTTCGGGTCCGGTCGGCTCTGGCAAAACCACGCTTATGTACCATCTTGCTAGGTTGAAATTTCCAGATAAACAG
ATTTTAACGATTGAAGATCCGGTAGAAATCAAACAGGAAGATATGCTCCAACTTCAGCTCAATGAAGCGATTGGGGCAAC
GTATGACAATCTGATTAAGCTGTCTCTTCGTCATCGGCCGGATTTACTGATTATTGGGGAAATACGAGATGCAGAAACAG
CAAGGGCAGTCATTCGTGCTAGTCTGACAGGTGCAACAGTTTTTTCTACTGTCCATGCTCGCAGTATTTCAGGGGTCTAT
GCTCGGATGCTAGAGCTGGGTGTCAGTACAGAGGAGTTAAATAATGCCCTTCAAGGAATTGCTTATCAACGTTTGATTGG
GGGAGGGGGTGTTGTAGATTTTGCTAAAGAAAACTTCCAAAACCATTCTGCTGACCAGTGGAACCAACAGATTGATAGCC
TTTTTGCAGCAGGATATATCAGTCATAGGCAGGCAGAGACAGAAAAGATTGTCTTTGGATCACCAGCGTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(8-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2Z5TMM2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus gordonii str. Challis substr. CH1

68.065

98.101

0.668
  comYA Streptococcus mutans UA159

67.203

98.418

0.661
  comYA Streptococcus mutans UA140

67.203

98.418

0.661
  comGA/cglA/cilD Streptococcus pneumoniae D39

63.782

98.734

0.63
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

63.782

98.734

0.63
  comGA/cglA/cilD Streptococcus pneumoniae R6

63.782

98.734

0.63
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

63.782

98.734

0.63
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

63.462

98.734

0.627
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

63.871

98.101

0.627
  comGA Lactococcus lactis subsp. cremoris KW2

54.019

98.418

0.532
  comGA Latilactobacillus sakei subsp. sakei 23K

42.599

87.658

0.373

Multiple sequence alignment