Detailed information NTG0506628

Bioinformatically predicted

Overview

• Name: comGC/cglC
• Type: Machinery gene
• Locus tag: I2437_RS08965
• Genome accession: NZ_CP065061
• Coordinates: 1908983..1909306 (-)
• Length: 107 a.a.
• NCBI ID: WP_012514782.1
• Uniprot ID: B4U056
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ33
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1903983..1914306

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I2437_RS08930 (IEMOCGPF_01783)	-	1904345..1904935 (+)	591	WP_165628050.1	hypothetical protein	-
I2437_RS08935 (IEMOCGPF_01784)	-	1905298..1906497 (-)	1200	WP_012678817.1	acetate kinase	-
I2437_RS08940 (IEMOCGPF_01785)	comYH	1906557..1907510 (-)	954	WP_043024962.1	class I SAM-dependent methyltransferase	Machinery gene
I2437_RS08945 (IEMOCGPF_01786)	comGG	1907572..1907934 (-)	363	WP_012677238.1	competence type IV pilus minor pilin ComGG	-
I2437_RS08950 (IEMOCGPF_01787)	comYF	1907912..1908346 (-)	435	WP_043983927.1	competence type IV pilus minor pilin ComGF	Machinery gene
I2437_RS08955 (IEMOCGPF_01788)	comGE	1908333..1908623 (-)	291	WP_014622143.1	competence type IV pilus minor pilin ComGE	-
I2437_RS08960 (IEMOCGPF_01789)	comGD	1908580..1909005 (-)	426	WP_012514783.1	competence type IV pilus minor pilin ComGD	-
I2437_RS08965 (IEMOCGPF_01790)	comGC/cglC	1908983..1909306 (-)	324	WP_012514782.1	competence type IV pilus major pilin ComGC	Machinery gene
I2437_RS08970 (IEMOCGPF_01791)	comYB	1909307..1910341 (-)	1035	WP_228274584.1	competence type IV pilus assembly protein ComGB	Machinery gene
I2437_RS08975 (IEMOCGPF_01792)	comGA/cglA	1910274..1911212 (-)	939	WP_165628048.1	competence type IV pilus ATPase ComGA	Machinery gene
I2437_RS08980 (IEMOCGPF_01793)	-	1911369..1912037 (-)	669	WP_165628047.1	ATP-binding cassette domain-containing protein	-
I2437_RS08985 (IEMOCGPF_01794)	-	1912039..1914042 (-)	2004	WP_111689762.1	DUF1430 domain-containing protein	-

Sequence

Protein

• Length: 107 a.a.
• Molecular weight: 12149.19 Da
• Isoelectric Point: 8.4057

>NTDB_id=506628 I2437_RS08965 WP_012514782.1 1908983..1909306(-) (comGC/cglC) [Streptococcus equi subsp. zooepidemicus strain SEZ33]
MKMRLSILKDQGVQAFTLLEMLLVLLIISVLMLLFVPNLSKQKDKVTDTGNAAVVKLVENQAELYELSHGEKPSLKQLQE
DGSISDKQQKAYQDYYAKHKDEAKKLN

Nucleotide

• Length: 324 bp

>NTDB_id=506628 I2437_RS08965 WP_012514782.1 1908983..1909306(-) (comGC/cglC) [Streptococcus equi subsp. zooepidemicus strain SEZ33]
ATGAAAATGAGATTATCAATCTTAAAAGATCAAGGTGTTCAGGCCTTCACTTTACTGGAAATGCTTCTGGTTTTGTTAAT
CATTAGTGTTTTGATGCTGTTATTTGTTCCAAATTTAAGTAAACAAAAGGATAAGGTGACAGACACAGGCAATGCTGCAG
TGGTAAAGCTGGTTGAAAATCAGGCAGAGCTTTATGAATTATCACATGGGGAAAAGCCAAGCCTGAAGCAGCTGCAAGAG
GATGGAAGTATCAGTGACAAGCAGCAAAAGGCTTATCAGGATTATTATGCAAAGCATAAAGATGAAGCTAAGAAGCTCAA
TTAA

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (14-34)

3D structure

• AlphaFold DB: B4U056

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGC/cglC	Streptococcus mitis SK321	59.813	100	0.598
comGC/cglC	Streptococcus pneumoniae Rx1	57.944	100	0.579
comGC/cglC	Streptococcus pneumoniae D39	57.944	100	0.579
comGC/cglC	Streptococcus pneumoniae R6	57.944	100	0.579
comGC/cglC	Streptococcus pneumoniae TIGR4	57.944	100	0.579
comYC	Streptococcus gordonii str. Challis substr. CH1	62.245	91.589	0.57
comGC/cglC	Streptococcus mitis NCTC 12261	61.616	92.523	0.57
comYC	Streptococcus mutans UA140	58.763	90.654	0.533
comYC	Streptococcus mutans UA159	58.763	90.654	0.533
comGC	Lactococcus lactis subsp. cremoris KW2	56.842	88.785	0.505
comYC	Streptococcus suis isolate S10	60	74.766	0.449
comGC	Staphylococcus aureus MW2	50	72.897	0.364
comGC	Staphylococcus aureus N315	50	72.897	0.364