Detailed information NTG0048933

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: SGGB_RS10160
• Genome accession: NC_017576
• Coordinates: 2047653..2048381 (-)
• Length: 242 a.a.
• NCBI ID: WP_012962512.1
• Uniprot ID: A0A139R4K2
• Organism: Streptococcus gallolyticus subsp. gallolyticus ATCC 43143
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2042653..2053381

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SGGB_RS10135 (SGGB_1989)	rsgA	2042876..2043748 (-)	873	WP_009854990.1	ribosome small subunit-dependent GTPase A	-
SGGB_RS10150 (SGGB_1990)	-	2045944..2046144 (-)	201	WP_009854991.1	hypothetical protein	-
SGGB_RS10155 (SGGB_1991)	comD/comD3	2046276..2047640 (-)	1365	WP_012962511.1	sensor histidine kinase	Regulator
SGGB_RS10160 (SGGB_1992)	comE/comE2	2047653..2048381 (-)	729	WP_012962512.1	LytR/AlgR family response regulator transcription factor	Regulator
SGGB_RS10165 (SGGB_1993)	-	2048480..2048773 (-)	294	WP_009854994.1	bacteriocin immunity protein	-
SGGB_RS10170 (SGGB_1994)	-	2048824..2049051 (-)	228	WP_009854995.1	hypothetical protein	-
SGGB_RS10175 (SGGB_1995)	-	2049321..2049632 (-)	312	WP_003066564.1	bacteriocin immunity protein	-
SGGB_RS10180 (SGGB_1996)	-	2049644..2049793 (-)	150	WP_009854997.1	hypothetical protein	-
SGGB_RS10185 (SGGB_1997)	-	2049803..2050102 (-)	300	WP_009854998.1	DUF3884 family protein	-
SGGB_RS10190 (SGGB_1998)	-	2050402..2050539 (+)	138	WP_009854999.1	hypothetical protein	-
SGGB_RS10195 (SGGB_1999)	-	2050561..2051868 (-)	1308	WP_012962514.1	sensor histidine kinase	-
SGGB_RS10200 (SGGB_2000)	comE/comE1	2051876..2052607 (-)	732	WP_009855001.1	response regulator transcription factor	Regulator
SGGB_RS10205 (SGGB_2001)	-	2052624..2052908 (-)	285	WP_231101259.1	LytTR family DNA-binding domain-containing protein	-
SGGB_RS10210 (SGGB_2002)	-	2053151..2053351 (-)	201	WP_009855003.1	hypothetical protein	-

Sequence

Protein

• Length: 242 a.a.
• Molecular weight: 28063.45 Da
• Isoelectric Point: 6.7499

>NTDB_id=48933 SGGB_RS10160 WP_012962512.1 2047653..2048381(-) (comE/comE2) [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
MIDIYVLEDDVNQQFRLEKMIDEVLVDNQWQHRCFELFGEPSRLITLIDETVPQIFFLDLDINGDKTKGIEVAKAIRDVS
KTATLVFVTTHSEFMLLTYRAQVSALDFIDKTDSDLAIKENLQACLKKVVEGQVPRLSLDTFIFENNKTKIRIPFEDILY
FETAEAHRLMLVTRTGQRNFYGTIREVKKANHKLFQCHKSYLINPDNVVSLDKKEGLVYFVGGKSCYVSKKHMKELKTKL
ES

Nucleotide

• Length: 729 bp

>NTDB_id=48933 SGGB_RS10160 WP_012962512.1 2047653..2048381(-) (comE/comE2) [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
ATGATTGATATTTATGTTTTGGAAGATGACGTAAATCAGCAGTTTCGCTTGGAAAAAATGATTGACGAGGTGCTTGTGGA
CAATCAGTGGCAACATCGTTGTTTTGAATTGTTTGGTGAGCCTAGTCGTCTTATCACTCTTATTGATGAAACGGTTCCTC
AAATCTTTTTCTTGGATTTGGATATCAATGGCGATAAAACGAAAGGAATTGAAGTTGCCAAGGCGATTAGAGACGTTTCG
AAAACAGCAACACTTGTCTTTGTTACAACGCATTCTGAATTTATGCTCCTGACCTATCGTGCGCAAGTCAGTGCCCTTGA
TTTCATTGATAAAACCGACAGTGACTTGGCAATCAAGGAAAATTTGCAGGCTTGTTTAAAGAAAGTCGTTGAAGGACAAG
TGCCTCGCCTAAGCTTGGATACCTTTATTTTTGAAAACAATAAAACCAAAATCAGAATACCATTTGAAGATATTCTTTAT
TTTGAAACGGCGGAAGCGCACCGTTTGATGTTGGTGACACGGACAGGACAGCGTAATTTTTACGGAACAATTAGAGAAGT
TAAAAAGGCAAATCATAAGCTATTTCAATGCCATAAATCCTATCTGATTAATCCTGATAATGTCGTCAGTTTGGATAAAA
AAGAAGGGCTTGTTTATTTTGTAGGTGGAAAATCTTGCTACGTTTCCAAAAAACACATGAAAGAATTAAAAACTAAACTA
GAAAGTTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (5-113)

3D structure

• AlphaFold DB: A0A139R4K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus equinus JB1	70.248	100	0.702
comE/comE1	Streptococcus equinus JB1	43.802	100	0.438
comE/blpR	Streptococcus mutans UA159	42.739	99.587	0.426