Detailed information NTG0048934

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: SGGB_RS10200
• Genome accession: NC_017576
• Coordinates: 2051876..2052607 (-)
• Length: 243 a.a.
• NCBI ID: WP_009855001.1
• Uniprot ID: A0A380K1N3
• Organism: Streptococcus gallolyticus subsp. gallolyticus ATCC 43143
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2046876..2057607

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SGGB_RS10160 (SGGB_1992)	comE/comE2	2047653..2048381 (-)	729	WP_012962512.1	LytR/AlgR family response regulator transcription factor	Regulator
SGGB_RS10165 (SGGB_1993)	-	2048480..2048773 (-)	294	WP_009854994.1	bacteriocin immunity protein	-
SGGB_RS10170 (SGGB_1994)	-	2048824..2049051 (-)	228	WP_009854995.1	hypothetical protein	-
SGGB_RS10175 (SGGB_1995)	-	2049321..2049632 (-)	312	WP_003066564.1	bacteriocin immunity protein	-
SGGB_RS10180 (SGGB_1996)	-	2049644..2049793 (-)	150	WP_009854997.1	hypothetical protein	-
SGGB_RS10185 (SGGB_1997)	-	2049803..2050102 (-)	300	WP_009854998.1	DUF3884 family protein	-
SGGB_RS10190 (SGGB_1998)	-	2050402..2050539 (+)	138	WP_009854999.1	hypothetical protein	-
SGGB_RS10195 (SGGB_1999)	-	2050561..2051868 (-)	1308	WP_012962514.1	sensor histidine kinase	-
SGGB_RS10200 (SGGB_2000)	comE/comE1	2051876..2052607 (-)	732	WP_009855001.1	response regulator transcription factor	Regulator
SGGB_RS10205 (SGGB_2001)	-	2052624..2052908 (-)	285	WP_231101259.1	LytTR family DNA-binding domain-containing protein	-
SGGB_RS10210 (SGGB_2002)	-	2053151..2053351 (-)	201	WP_009855003.1	hypothetical protein	-
SGGB_RS10220 (SGGB_2003)	-	2053672..2054685 (-)	1014	WP_009855005.1	bacteriocin biosynthesis protein	-
SGGB_RS10225 (SGGB_2005)	-	2055743..2055940 (-)	198	WP_009855009.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
SGGB_RS10230 (SGGB_2006)	-	2055959..2056210 (-)	252	WP_009855010.1	bacteriocin class II family protein	-
SGGB_RS10235 (SGGB_2007)	-	2056457..2056714 (+)	258	WP_009855011.1	hypothetical protein	-

Sequence

Protein

• Length: 243 a.a.
• Molecular weight: 28456.61 Da
• Isoelectric Point: 5.4335

>NTDB_id=48934 SGGB_RS10200 WP_009855001.1 2051876..2052607(-) (comE/comE1) [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
MLDIYVLEDNIIQQFRMEREIATIMAKNNWDYQRIEVFSSANEIIAKATEKGEHQIFFLDLEIRDDEKQGIDVAKAIREK
DATAIIVFVTTHSEFMLLTYQALVGAIDFIDKNLNDQAFSERIELCLKEAMKHQNDNFGENSFLFETPKARVRMPYSDIL
YFETSPAVHRVIMHTKNDRMEFYATIAEIAKSDKRLFKCHRSFIINVDNVVRFDKATRSVYFETGDTCLVSRDKIKPLLN
EMR

Nucleotide

• Length: 732 bp

>NTDB_id=48934 SGGB_RS10200 WP_009855001.1 2051876..2052607(-) (comE/comE1) [Streptococcus gallolyticus subsp. gallolyticus ATCC 43143]
ATGTTAGATATTTATGTACTAGAGGATAATATCATACAGCAATTTCGTATGGAACGCGAGATTGCGACCATTATGGCAAA
AAATAATTGGGACTATCAGAGAATAGAGGTGTTTAGTTCCGCAAATGAGATTATAGCTAAGGCAACTGAAAAAGGAGAGC
ATCAAATTTTCTTTCTTGATTTAGAAATCAGAGACGACGAAAAACAAGGAATTGATGTCGCTAAAGCTATTCGTGAAAAA
GATGCAACAGCTATCATTGTTTTTGTAACAACTCATTCAGAATTTATGCTGCTGACCTACCAAGCGTTAGTAGGGGCAAT
TGATTTTATTGATAAGAACCTGAATGACCAAGCATTTAGTGAACGCATAGAGTTGTGCCTAAAGGAAGCCATGAAACATC
AAAATGATAATTTCGGCGAAAACTCCTTTTTATTTGAAACTCCTAAAGCACGTGTGCGCATGCCATATAGTGACATTCTC
TATTTTGAAACCTCTCCTGCTGTGCACCGCGTGATTATGCATACGAAAAATGACAGAATGGAATTTTATGCAACGATTGC
AGAGATTGCTAAATCAGACAAACGTCTTTTTAAGTGTCATCGTTCTTTTATTATTAATGTGGATAATGTGGTCAGATTTG
ATAAAGCGACACGAAGTGTTTATTTCGAAACTGGGGACACTTGCCTAGTTTCTAGAGATAAAATAAAACCTCTATTAAAT
GAGATGAGGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (11-123)

• LytTr DNA-binding domain (LytTR) (152-238)

3D structure

• AlphaFold DB: A0A380K1N3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	71.605	100	0.716
comE/blpR	Streptococcus mutans UA159	47.699	98.354	0.469
comE/comE2	Streptococcus equinus JB1	46.694	99.588	0.465