Detailed information NTG0044159

Bioinformatically predicted

Overview

• Name: comX/comX2
• Type: Regulator
• Locus tag: HMPREF1038_RS00075
• Genome accession: NC_018630
• Coordinates: 14450..14929 (+)
• Length: 159 a.a.
• NCBI ID: WP_000588897.1
• Uniprot ID: Q9R2W8
• Organism: Streptococcus pneumoniae gamPNI0373
• Function: activate transcription of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 9450..19929

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HMPREF1038_RS00060 (HMPREF1038_00011)	tilS	10531..11808 (+)	1278	WP_001208983.1	tRNA lysidine(34) synthetase TilS	-
HMPREF1038_RS00065 (HMPREF1038_00012)	hpt	11812..12354 (+)	543	WP_000892184.1	hypoxanthine phosphoribosyltransferase	-
HMPREF1038_RS00070 (HMPREF1038_00013)	ftsH	12370..14328 (+)	1959	WP_000744537.1	ATP-dependent zinc metalloprotease FtsH	-
HMPREF1038_RS00075 (HMPREF1038_00014)	comX/comX2	14450..14929 (+)	480	WP_000588897.1	sigma-70 family RNA polymerase sigma factor	Regulator

Sequence

Protein

• Length: 159 a.a.
• Molecular weight: 19873.52 Da
• Isoelectric Point: 7.3797

>NTDB_id=44159 HMPREF1038_RS00075 WP_000588897.1 14450..14929(+) (comX/comX2) [Streptococcus pneumoniae gamPNI0373]
MIKELYEEVQGTVYKCRNEYYLHLWELSDWDQEGMLCLHELISREEGLVDDIPRLRKYFKTKFRNRILDYIRKQESQKRR
YDKEPYEEVGEISHRISEGGLWLDDYYLFHETLRDYRNKQSKEKQEELERVLSNERFRGRQRVLRDLRIVFKEFTIRTH

Nucleotide

• Length: 480 bp

>NTDB_id=44159 HMPREF1038_RS00075 WP_000588897.1 14450..14929(+) (comX/comX2) [Streptococcus pneumoniae gamPNI0373]
ATGATTAAAGAATTGTATGAAGAAGTCCAAGGGACTGTTTATAAGTGTAGAAATGAATATTACCTTCATTTATGGGAATT
GTCGGATTGGGACCAAGAAGGCATGCTCTGCTTACATGAATTGATTAGTAGAGAAGAAGGACTGGTAGACGATATTCCAC
GTTTAAGGAAATATTTCAAAACCAAGTTTCGAAATCGAATTTTAGACTATATCCGTAAGCAGGAAAGTCAGAAGCGTAGA
TACGATAAAGAACCCTATGAAGAAGTGGGAGAGATCAGTCATCGTATAAGTGAGGGGGGTCTCTGGCTAGATGATTATTA
TCTCTTTCATGAAACACTAAGAGATTATAGAAACAAACAAAGTAAAGAGAAACAAGAAGAACTAGAACGCGTCTTAAGCA
ATGAACGATTTCGAGGGCGTCAAAGAGTATTAAGAGACTTACGCATTGTGTTTAAGGAGTTTACTATCCGTACCCACTAG

Domains

No domain identified.

3D structure

• AlphaFold DB: Q9R2W8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX/comX2	Streptococcus pneumoniae Rx1	100	100	1
comX/comX1	Streptococcus pneumoniae Rx1	100	100	1
comX/comX2	Streptococcus pneumoniae D39	100	100	1
comX/comX1	Streptococcus pneumoniae D39	100	100	1
comX/comX2	Streptococcus pneumoniae R6	100	100	1
comX/comX1	Streptococcus pneumoniae R6	100	100	1
comX/comX2	Streptococcus pneumoniae TIGR4	99.371	100	0.994
comX/comX1	Streptococcus pneumoniae TIGR4	99.371	100	0.994
comX/sigX/comX1/sigX1	Streptococcus mitis NCTC 12261	92.453	100	0.925
comX/sigX/comX2/sigX2	Streptococcus mitis NCTC 12261	92.453	100	0.925
comX/sigX/comX2/sigX2	Streptococcus mitis SK321	90.566	100	0.906
comX/sigX/comX1/sigX1	Streptococcus mitis SK321	89.241	99.371	0.887
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	48.718	98.113	0.478
comX/sigX	Streptococcus mutans UA159	46	94.34	0.434
comX/sigX	Streptococcus suis isolate S10	45.695	94.969	0.434
comX/sigX	Streptococcus suis D9	45.695	94.969	0.434
comX/sigX	Streptococcus suis P1/7	45.695	94.969	0.434
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	39.216	96.226	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	40	94.34	0.377
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	40	94.34	0.377
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	40	94.34	0.377