Detailed information NTG0419335

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: GWC80_RS05440
• Genome accession: NZ_CP048007
• Coordinates: 1161998..1163041 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain CGMH-SL131
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1156998..1168041

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GWC80_RS05415	-	1157288..1158649 (-)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-
GWC80_RS05420	-	1158783..1159763 (-)	981	WP_249689300.1	aromatic acid exporter family protein	-
GWC80_RS05425	map	1160008..1160763 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
GWC80_RS05430	-	1160889..1161275 (+)	387	WP_002477960.1	hypothetical protein	-
GWC80_RS05435	liaF	1161300..1162001 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
GWC80_RS05440	vraS	1161998..1163041 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
GWC80_RS05445	vraR	1163031..1163660 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
GWC80_RS05450	-	1163833..1165062 (-)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
GWC80_RS05455	-	1165265..1165549 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
GWC80_RS05460	-	1165556..1166020 (-)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
GWC80_RS05465	-	1166184..1166369 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
GWC80_RS05470	-	1166382..1167620 (+)	1239	WP_002461326.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=419335 GWC80_RS05440 WP_002461334.1 1161998..1163041(+) (vraS) [Staphylococcus lugdunensis strain CGMH-SL131]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=419335 GWC80_RS05440 WP_002461334.1 1161998..1163041(+) (vraS) [Staphylococcus lugdunensis strain CGMH-SL131]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911