Detailed information NTG0419335

Bioinformatically predicted

Overview

• Name: comX
• Type: Regulator
• Locus tag: IBB96_RS00885
• Genome accession: NZ_CP061023
• Coordinates: 150753..151250 (+)
• Length: 165 a.a.
• NCBI ID: WP_002949220.1
• Uniprot ID: Q5M6C4
• Organism: Streptococcus thermophilus strain 13499
• Function: activation of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 145753..156250

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IBB96_RS00860 (IBB96_00870)	-	147168..147490 (-)	323	Protein_117	transposase	-
IBB96_RS00865 (IBB96_00875)	-	147679..148005 (+)	327	WP_014607875.1	M20/M25/M40 family metallo-hydrolase	-
IBB96_RS00870 (IBB96_00880)	-	148087..149277 (+)	1191	WP_011680651.1	cyclopropane-fatty-acyl-phospholipid synthase family protein	-
IBB96_RS00875 (IBB96_00885)	-	149535..149999 (-)	465	Protein_120	transposase family protein	-
IBB96_RS00880 (IBB96_00890)	-	150357..150446 (+)	90	Protein_121	IS200/IS605 family transposase	-
IBB96_RS00885 (IBB96_00895)	comX	150753..151250 (+)	498	WP_002949220.1	sigma factor	Regulator
IBB96_RS00890 (IBB96_00900)	-	151350..152192 (-)	843	WP_011225338.1	mechanosensitive ion channel family protein	-
IBB96_RS00895 (IBB96_00905)	tig	152333..153616 (+)	1284	WP_011680653.1	trigger factor	-
IBB96_RS00900 (IBB96_00910)	rpoE	153774..154349 (+)	576	WP_002949228.1	DNA-directed RNA polymerase subunit delta	-
IBB96_RS00905 (IBB96_00915)	-	154600..156204 (+)	1605	WP_002949230.1	CTP synthase	-

Sequence

Protein

• Length: 165 a.a.
• Molecular weight: 20160.12 Da
• Isoelectric Point: 5.2073

>NTDB_id=419335 IBB96_RS00885 WP_002949220.1 150753..151250(+) (comX) [Streptococcus thermophilus strain 13499]
MEQEVFVKAYEKVRPIVLKAFRQYFIQLWDQADMEQEAMMTLYQLLKKFPDLEKDDDKLRRYFKTKFRNRLNDEVRRQES
VKRQANRQCYVEISDIAFCIPNKELDMVDRLAYDEQLNAFREQLSSEDSLKLDRLLGGECFRGRKKMIRELRFWMVDFDP
CNEED

Nucleotide

• Length: 498 bp

>NTDB_id=419335 IBB96_RS00885 WP_002949220.1 150753..151250(+) (comX) [Streptococcus thermophilus strain 13499]
ATGGAACAAGAAGTTTTTGTTAAGGCATATGAAAAGGTAAGGCCAATTGTACTTAAGGCTTTTAGGCAATACTTTATTCA
GCTTTGGGATCAAGCTGACATGGAGCAAGAGGCGATGATGACTTTGTATCAGCTTTTAAAAAAGTTTCCTGATTTAGAGA
AAGATGATGATAAGTTACGTCGTTACTTTAAAACTAAGTTTAGGAATCGACTTAATGATGAAGTGAGGCGGCAGGAGTCA
GTAAAACGTCAAGCTAATAGACAGTGCTATGTTGAAATTTCAGATATTGCCTTTTGTATTCCCAATAAGGAGCTAGATAT
GGTTGATAGACTTGCTTATGATGAACAGCTTAATGCTTTTCGTGAGCAGTTATCATCGGAAGATTCTCTTAAGTTGGATC
GATTGTTGGGTGGTGAATGCTTTAGGGGAAGGAAAAAGATGATACGAGAGTTAAGATTTTGGATGGTTGACTTTGATCCA
TGTAATGAAGAAGACTGA

Domains

Predicted by InterProScan.

• Sigma-70 region 2 (Sigma70_r2) (10-79)

3D structure

• AlphaFold DB: Q5M6C4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX	Streptococcus thermophilus LMD-9	100	100	1
comX	Streptococcus thermophilus LMG 18311	100	100	1
comX/sigX	Streptococcus salivarius strain HSISS4	89.091	100	0.891
comX	Streptococcus salivarius SK126	88.485	100	0.885
comX	Streptococcus sobrinus strain NIDR 6715-7	41.975	98.182	0.412
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	41.667	94.545	0.394
comX/sigX	Streptococcus mutans UA159	41.026	94.545	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX	Streptococcus suis D9	40.523	92.727	0.376
comX/sigX	Streptococcus suis isolate S10	40.523	92.727	0.376
comX/sigX	Streptococcus suis P1/7	40.523	92.727	0.376