Detailed information NTG0039611

Bioinformatically predicted

Overview

• Name: comX
• Type: Regulator
• Locus tag: STH8232_RS01015
• Genome accession: NC_017581
• Coordinates: 175899..176396 (+)
• Length: 165 a.a.
• NCBI ID: WP_002949220.1
• Uniprot ID: Q5M6C4
• Organism: Streptococcus thermophilus JIM 8232
• Function: activation of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 170899..181396

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STH8232_RS10985	-	172313..172635 (-)	323	Protein_140	transposase	-
STH8232_RS01000 (STH8232_0213)	-	172824..173150 (+)	327	WP_014607875.1	M20/M25/M40 family metallo-hydrolase	-
STH8232_RS01005 (STH8232_0214)	-	173232..174422 (+)	1191	WP_011680651.1	SAM-dependent methyltransferase	-
STH8232_RS01010 (STH8232_0217)	-	174681..175145 (-)	465	Protein_143	transposase family protein	-
STH8232_RS10170	-	175503..175607 (+)	105	Protein_144	IS200/IS605 family transposase	-
STH8232_RS01015 (STH8232_0219)	comX	175899..176396 (+)	498	WP_002949220.1	sigma factor	Regulator
STH8232_RS01020 (STH8232_0221)	-	176496..177338 (-)	843	WP_041828985.1	mechanosensitive ion channel family protein	-
STH8232_RS01025 (STH8232_0222)	tig	177479..178762 (+)	1284	WP_011680653.1	trigger factor	-
STH8232_RS01030 (STH8232_0223)	rpoE	178920..179495 (+)	576	WP_002949228.1	DNA-directed RNA polymerase subunit delta	-
STH8232_RS01035 (STH8232_0224)	-	179746..181350 (+)	1605	WP_002949230.1	CTP synthase	-

Sequence

Protein

• Length: 165 a.a.
• Molecular weight: 20160.12 Da
• Isoelectric Point: 5.2073

>NTDB_id=39611 STH8232_RS01015 WP_002949220.1 175899..176396(+) (comX) [Streptococcus thermophilus JIM 8232]
MEQEVFVKAYEKVRPIVLKAFRQYFIQLWDQADMEQEAMMTLYQLLKKFPDLEKDDDKLRRYFKTKFRNRLNDEVRRQES
VKRQANRQCYVEISDIAFCIPNKELDMVDRLAYDEQLNAFREQLSSEDSLKLDRLLGGECFRGRKKMIRELRFWMVDFDP
CNEED

Nucleotide

• Length: 498 bp

>NTDB_id=39611 STH8232_RS01015 WP_002949220.1 175899..176396(+) (comX) [Streptococcus thermophilus JIM 8232]
ATGGAACAAGAAGTTTTTGTTAAGGCATATGAAAAGGTAAGGCCAATTGTACTTAAGGCTTTTAGGCAATACTTTATTCA
GCTTTGGGATCAAGCTGACATGGAGCAAGAGGCGATGATGACTTTGTATCAGCTTTTAAAAAAGTTTCCTGATTTAGAGA
AAGATGATGATAAGTTACGTCGTTACTTTAAAACTAAGTTTAGGAATCGACTTAATGATGAAGTGAGGCGGCAGGAGTCA
GTAAAACGTCAAGCTAATAGACAGTGCTATGTTGAAATTTCAGATATTGCCTTTTGTATTCCCAATAAGGAGCTAGATAT
GGTTGATAGACTTGCTTATGATGAACAGCTTAATGCTTTTCGTGAGCAGTTATCATCGGAAGATTCTCTTAAGTTGGATC
GATTGTTGGGTGGTGAATGCTTTAGGGGAAGGAAAAAGATGATACGAGAGTTAAGATTTTGGATGGTTGACTTTGATCCA
TGTAATGAAGAAGACTGA

Domains

Predicted by InterProScan.

• Sigma-70 region 2 (Sigma70_r2) (10-79)

3D structure

• AlphaFold DB: Q5M6C4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX	Streptococcus thermophilus LMD-9	100	100	1
comX	Streptococcus thermophilus LMG 18311	100	100	1
comX/sigX	Streptococcus salivarius strain HSISS4	89.091	100	0.891
comX	Streptococcus salivarius SK126	88.485	100	0.885
comX	Streptococcus sobrinus strain NIDR 6715-7	41.975	98.182	0.412
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	41.667	94.545	0.394
comX/sigX	Streptococcus mutans UA159	41.026	94.545	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX	Streptococcus suis D9	40.523	92.727	0.376
comX/sigX	Streptococcus suis isolate S10	40.523	92.727	0.376
comX/sigX	Streptococcus suis P1/7	40.523	92.727	0.376