Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   SMUNN2025_RS00960 Genome accession   NC_013928
Coordinates   203722..204663 (+) Length   313 a.a.
NCBI ID   WP_002263435.1    Uniprot ID   -
Organism   Streptococcus mutans NN2025     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 198722..209663
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNN2025_RS00950 (SmuNN2025_0169) rpoC 199451..203080 (+) 3630 WP_002263433.1 DNA-directed RNA polymerase subunit beta' -
  SMUNN2025_RS00955 (SmuNN2025_0170) - 203207..203590 (+) 384 WP_002263434.1 DUF1033 family protein -
  SMUNN2025_RS00960 (SmuNN2025_0171) comYA 203722..204663 (+) 942 WP_002263435.1 competence type IV pilus ATPase ComGA Machinery gene
  SMUNN2025_RS00965 (SmuNN2025_0172) comYB 204599..205630 (+) 1032 WP_255262945.1 competence type IV pilus assembly protein ComGB Machinery gene
  SMUNN2025_RS00970 (SmuNN2025_0173) comYC 205630..205944 (+) 315 WP_002263437.1 competence type IV pilus major pilin ComGC Machinery gene
  SMUNN2025_RS00975 (SmuNN2025_0174) comYD 205931..206335 (+) 405 WP_002273742.1 competence type IV pilus minor pilin ComGD Machinery gene
  SMUNN2025_RS00980 (SmuNN2025_0175) comYE 206307..206600 (+) 294 WP_002263439.1 competence type IV pilus minor pilin ComGE Machinery gene
  SMUNN2025_RS00985 (SmuNN2025_0176) comYF 206587..207021 (+) 435 WP_002264245.1 competence type IV pilus minor pilin ComGF Machinery gene
  SMUNN2025_RS00990 (SmuNN2025_0177) comYG 206999..207388 (+) 390 WP_002278009.1 competence type IV pilus minor pilin ComGG Machinery gene
  SMUNN2025_RS00995 (SmuNN2025_0178) comYH 207443..208396 (+) 954 WP_002278010.1 class I SAM-dependent methyltransferase Machinery gene
  SMUNN2025_RS01000 (SmuNN2025_0179) - 208455..209654 (+) 1200 WP_002265895.1 acetate kinase -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35739.09 Da        Isoelectric Point: 8.0347

>NTDB_id=36558 SMUNN2025_RS00960 WP_002263435.1 203722..204663(+) (comYA) [Streptococcus mutans NN2025]
MVQKLGRKIIAEAVQNKAQDIYIIPKKESYELYMRIGNERRFIDVYDHHFMANLISHFKFVAGMNVGEKRRSQLGSCDYS
YDEGKVISLRLSSVGDYRGYESLVIRLLFSGRHDLKFWFNSMDLILNEIKGRGLYLFSGPVGSGKTSLMYQLVKLRFETK
QVITIEDPVEIKQDNMLQLQLNESIDMTYDNLIKLSLRHRPDILIIGEIRDKETARAVIRASLTGAMVFSTIHAKSIPGV
YARMLELGTSSEELQNALRGIVYQRLIGGGGIIDFAKGDYQNHSAKKWNKQIYDLFTAGYITEGEAQAEEIED

Nucleotide


Download         Length: 942 bp        

>NTDB_id=36558 SMUNN2025_RS00960 WP_002263435.1 203722..204663(+) (comYA) [Streptococcus mutans NN2025]
ATGGTTCAAAAATTAGGTAGAAAAATCATTGCCGAAGCTGTTCAAAATAAAGCACAAGATATCTATATTATTCCTAAAAA
AGAATCTTATGAGCTTTATATGAGAATAGGGAATGAAAGGAGGTTCATTGATGTTTATGACCATCATTTCATGGCTAATC
TTATTAGTCACTTTAAATTTGTTGCAGGAATGAATGTTGGTGAGAAAAGACGAAGTCAGCTGGGCTCTTGTGATTATTCT
TATGATGAAGGGAAAGTTATTTCATTAAGGTTATCAAGTGTAGGAGATTATCGTGGTTATGAAAGTTTGGTTATTCGCTT
ACTTTTTTCTGGACGTCACGATTTAAAATTCTGGTTTAACAGTATGGATTTGATTTTAAATGAAATCAAGGGGCGAGGGC
TTTATCTTTTTTCGGGTCCAGTTGGAAGTGGCAAAACAAGTTTGATGTATCAATTGGTAAAACTAAGATTTGAGACCAAA
CAGGTAATTACCATTGAAGATCCTGTGGAAATTAAGCAAGATAATATGTTACAACTGCAGCTTAATGAAAGCATTGATAT
GACTTATGATAATTTAATTAAATTATCTCTGAGGCATCGTCCGGATATTTTAATTATTGGAGAAATTCGAGATAAAGAAA
CCGCCAGAGCTGTTATTAGAGCAAGTCTTACAGGGGCAATGGTATTCTCAACTATCCATGCTAAAAGCATTCCAGGTGTT
TATGCTAGGATGTTAGAATTGGGTACTAGTTCAGAAGAATTACAAAATGCTTTGCGTGGTATTGTTTATCAACGTTTAAT
AGGGGGAGGAGGGATTATTGACTTTGCCAAAGGGGATTATCAAAACCACTCAGCAAAAAAGTGGAACAAACAAATTTATG
ACCTTTTTACAGCAGGATATATCACTGAAGGAGAAGCACAAGCAGAAGAAATTGAAGATTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(8-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA159

100

100

1
  comYA Streptococcus mutans UA140

99.681

100

0.997
  comYA Streptococcus gordonii str. Challis substr. CH1

67.093

100

0.671
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

66.026

99.681

0.658
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

65.916

99.361

0.655
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

65.916

99.361

0.655
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

65.916

99.361

0.655
  comGA/cglA/cilD Streptococcus pneumoniae D39

65.916

99.361

0.655
  comGA/cglA/cilD Streptococcus pneumoniae R6

65.916

99.361

0.655
  comGA Lactococcus lactis subsp. cremoris KW2

52.412

99.361

0.521

Multiple sequence alignment