Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   DV129_RS09130 Genome accession   NZ_CP031247
Coordinates   1687818..1688759 (+) Length   313 a.a.
NCBI ID   WP_000249571.1    Uniprot ID   A0A0B7M3Q7
Organism   Streptococcus pneumoniae strain M23734     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1682818..1693759
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV129_RS09110 - 1682884..1684701 (+) 1818 WP_001220841.1 acyltransferase family protein -
  DV129_RS09115 nagA 1684854..1686005 (+) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  DV129_RS09120 - 1686168..1687226 (+) 1059 WP_000649471.1 zinc-dependent alcohol dehydrogenase family protein -
  DV129_RS09125 - 1687377..1687742 (+) 366 WP_000286415.1 DUF1033 family protein -
  DV129_RS09130 comGA/cglA/cilD 1687818..1688759 (+) 942 WP_000249571.1 competence type IV pilus ATPase ComGA Machinery gene
  DV129_RS09135 comGB/cglB 1688707..1689723 (+) 1017 WP_001844679.1 competence type IV pilus assembly protein ComGB Machinery gene
  DV129_RS09140 comGC/cglC 1689725..1690051 (+) 327 WP_000738633.1 comG operon protein ComGC Machinery gene
  DV129_RS09145 comGD/cglD 1690044..1690448 (+) 405 WP_000588020.1 competence type IV pilus minor pilin ComGD Machinery gene
  DV129_RS09150 comGE/cglE 1690411..1690713 (+) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  DV129_RS09155 comGF/cglF 1690676..1691137 (+) 462 WP_000250531.1 competence type IV pilus minor pilin ComGF Machinery gene
  DV129_RS09160 comGG/cglG 1691115..1691528 (+) 414 WP_000265631.1 competence type IV pilus minor pilin ComGG Machinery gene
  DV129_RS09170 - 1691665..1692259 (+) 595 Protein_1712 methyltransferase domain-containing protein -
  DV129_RS09175 comYH 1692320..1693273 (+) 954 WP_000345116.1 class I SAM-dependent methyltransferase Machinery gene

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35591.51 Da        Isoelectric Point: 6.0083

>NTDB_id=304789 DV129_RS09130 WP_000249571.1 1687818..1688759(+) (comGA/cglA/cilD) [Streptococcus pneumoniae strain M23734]
MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=304789 DV129_RS09130 WP_000249571.1 1687818..1688759(+) (comGA/cglA/cilD) [Streptococcus pneumoniae strain M23734]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCAGCTCGGAAAAAAGGGACGCAGGATATTTATTTTGTCCCTAAGTT
AGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGACATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGCCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M3Q7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

99.042

100

0.99
  comGA/cglA/cilD Streptococcus pneumoniae D39

99.042

100

0.99
  comGA/cglA/cilD Streptococcus pneumoniae R6

99.042

100

0.99
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

99.042

100

0.99
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

96.805

100

0.968
  comYA Streptococcus gordonii str. Challis substr. CH1

77.742

99.042

0.77
  comYA Streptococcus mutans UA159

65.916

99.361

0.655
  comYA Streptococcus mutans UA140

65.916

99.361

0.655
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.581

99.042

0.62
  comGA Lactococcus lactis subsp. cremoris KW2

54.808

99.681

0.546
  comGA Latilactobacillus sakei subsp. sakei 23K

42.642

84.665

0.361

Multiple sequence alignment