Detailed information NTG0272541

Bioinformatically predicted

Overview

• Name: comX
• Type: Regulator
• Locus tag: D1O36_RS00865
• Genome accession: NZ_CP031881
• Coordinates: 140807..141304 (+)
• Length: 165 a.a.
• NCBI ID: WP_002949220.1
• Uniprot ID: Q5M6C4
• Organism: Streptococcus thermophilus strain ST106
• Function: activation of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 135807..146304

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D1O36_RS00835 (D1O36_00835)	-	136892..137113 (+)	222	WP_002948904.1	DUF4649 family protein	-
D1O36_RS00840 (D1O36_00840)	-	137198..137514 (-)	317	Protein_111	transposase	-
D1O36_RS00845 (D1O36_00845)	-	137794..138036 (+)	243	WP_246752677.1	M20/M25/M40 family metallo-hydrolase	-
D1O36_RS00850 (D1O36_00850)	-	138139..139329 (+)	1191	WP_134973038.1	cyclopropane-fatty-acyl-phospholipid synthase family protein	-
D1O36_RS00855 (D1O36_00855)	-	139589..140053 (-)	465	Protein_114	transposase family protein	-
D1O36_RS00860 (D1O36_00860)	-	140411..140500 (+)	90	Protein_115	IS200/IS605 family transposase	-
D1O36_RS00865 (D1O36_00865)	comX	140807..141304 (+)	498	WP_002949220.1	sigma factor	Regulator
D1O36_RS00870 (D1O36_00870)	-	141404..142246 (-)	843	WP_064355676.1	mechanosensitive ion channel family protein	-
D1O36_RS00875 (D1O36_00875)	tig	142387..143670 (+)	1284	WP_134973039.1	trigger factor	-
D1O36_RS00880 (D1O36_00880)	rpoE	143828..144403 (+)	576	WP_002949228.1	DNA-directed RNA polymerase subunit delta	-
D1O36_RS00885 (D1O36_00885)	-	144654..146258 (+)	1605	WP_002949230.1	CTP synthase	-

Sequence

Protein

• Length: 165 a.a.
• Molecular weight: 20160.12 Da
• Isoelectric Point: 5.2073

>NTDB_id=272541 D1O36_RS00865 WP_002949220.1 140807..141304(+) (comX) [Streptococcus thermophilus strain ST106]
MEQEVFVKAYEKVRPIVLKAFRQYFIQLWDQADMEQEAMMTLYQLLKKFPDLEKDDDKLRRYFKTKFRNRLNDEVRRQES
VKRQANRQCYVEISDIAFCIPNKELDMVDRLAYDEQLNAFREQLSSEDSLKLDRLLGGECFRGRKKMIRELRFWMVDFDP
CNEED

Nucleotide

• Length: 498 bp

>NTDB_id=272541 D1O36_RS00865 WP_002949220.1 140807..141304(+) (comX) [Streptococcus thermophilus strain ST106]
ATGGAACAAGAAGTTTTTGTTAAGGCATATGAAAAGGTAAGGCCAATTGTACTTAAGGCTTTTAGGCAATACTTTATTCA
GCTTTGGGATCAAGCTGACATGGAGCAAGAGGCGATGATGACTTTGTATCAGCTTTTAAAAAAGTTTCCTGATTTAGAGA
AAGATGATGATAAGTTACGTCGTTACTTTAAAACTAAGTTTAGGAATCGACTTAATGATGAAGTGAGGCGGCAGGAGTCA
GTAAAACGTCAAGCTAATAGACAGTGCTATGTTGAAATTTCAGATATTGCCTTTTGTATTCCCAATAAGGAGCTAGATAT
GGTTGATAGACTTGCTTATGATGAACAGCTTAATGCTTTTCGTGAGCAGTTATCATCGGAAGATTCTCTTAAGTTGGATC
GATTGTTGGGTGGTGAATGCTTTAGGGGAAGGAAAAAGATGATACGAGAGTTAAGATTTTGGATGGTTGACTTTGATCCA
TGTAATGAAGAAGACTGA

Domains

Predicted by InterProScan.

• Sigma-70 region 2 (Sigma70_r2) (10-79)

3D structure

• AlphaFold DB: Q5M6C4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX	Streptococcus thermophilus LMD-9	100	100	1
comX	Streptococcus thermophilus LMG 18311	100	100	1
comX/sigX	Streptococcus salivarius strain HSISS4	89.091	100	0.891
comX	Streptococcus salivarius SK126	88.485	100	0.885
comX	Streptococcus sobrinus strain NIDR 6715-7	41.975	98.182	0.412
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	41.667	94.545	0.394
comX/sigX	Streptococcus mutans UA159	41.026	94.545	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX	Streptococcus suis D9	40.523	92.727	0.376
comX/sigX	Streptococcus suis isolate S10	40.523	92.727	0.376
comX/sigX	Streptococcus suis P1/7	40.523	92.727	0.376