Detailed information NTG0259487

Bioinformatically predicted

Overview

• Name: comX
• Type: Regulator
• Locus tag: DQ228_RS00735
• Genome accession: NZ_CP030250
• Coordinates: 127009..127506 (+)
• Length: 165 a.a.
• NCBI ID: WP_002949220.1
• Uniprot ID: Q5M6C4
• Organism: Streptococcus thermophilus strain CS20
• Function: activation of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 122009..132506

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQ228_RS00705	-	123077..123298 (+)	222	WP_002948904.1	DUF4649 family protein	-
DQ228_RS00710	-	123383..123699 (-)	317	Protein_111	transposase	-
DQ228_RS00715	-	123895..124239 (+)	345	WP_023909336.1	aminoacylase	-
DQ228_RS00720	-	124342..125532 (+)	1191	WP_024704158.1	SAM-dependent methyltransferase	-
DQ228_RS00725	-	125791..126255 (-)	465	Protein_114	transposase family protein	-
DQ228_RS00730	-	126613..126717 (+)	105	Protein_115	IS200/IS605 family transposase	-
DQ228_RS00735	comX	127009..127506 (+)	498	WP_002949220.1	sigma factor	Regulator
DQ228_RS00740	-	127606..128448 (-)	843	WP_024704159.1	mechanosensitive ion channel family protein	-
DQ228_RS00745	tig	128589..129872 (+)	1284	WP_011680653.1	trigger factor	-
DQ228_RS00750	rpoE	130030..130605 (+)	576	WP_002949228.1	DNA-directed RNA polymerase subunit delta	-
DQ228_RS00755	-	130856..132460 (+)	1605	WP_002949230.1	CTP synthase	-

Sequence

Protein

• Length: 165 a.a.
• Molecular weight: 20160.12 Da
• Isoelectric Point: 5.2073

>NTDB_id=259487 DQ228_RS00735 WP_002949220.1 127009..127506(+) (comX) [Streptococcus thermophilus strain CS20]
MEQEVFVKAYEKVRPIVLKAFRQYFIQLWDQADMEQEAMMTLYQLLKKFPDLEKDDDKLRRYFKTKFRNRLNDEVRRQES
VKRQANRQCYVEISDIAFCIPNKELDMVDRLAYDEQLNAFREQLSSEDSLKLDRLLGGECFRGRKKMIRELRFWMVDFDP
CNEED

Nucleotide

• Length: 498 bp

>NTDB_id=259487 DQ228_RS00735 WP_002949220.1 127009..127506(+) (comX) [Streptococcus thermophilus strain CS20]
ATGGAACAAGAAGTTTTTGTTAAGGCATATGAAAAGGTAAGGCCAATTGTACTTAAGGCGTTTAGGCAATACTTTATTCA
GCTTTGGGATCAAGCTGACATGGAGCAAGAGGCGATGATGACTTTGTATCAGCTTTTAAAAAAGTTTCCTGATTTAGAGA
AAGATGATGATAAGTTACGTCGTTACTTTAAAACTAAGTTTAGGAATCGACTTAATGATGAAGTGAGGCGGCAGGAGTCA
GTAAAACGTCAAGCTAATAGACAGTGTTATGTTGAAATTTCAGATATTGCCTTTTGTATTCCCAATAAGGAGCTAGATAT
GGTTGATAGACTTGCTTATGATGAACAGCTTAATGCTTTTCGTGAGCAGTTATCATCGGAAGATTCTCTTAAGTTGGATC
GATTGTTGGGTGGTGAATGCTTTAGGGGAAGGAAAAAGATGATACGAGAGTTAAGATTTTGGATGGTTGACTTTGATCCA
TGTAATGAAGAAGACTGA

Domains

Predicted by InterProScan.

• Sigma-70 region 2 (Sigma70_r2) (10-79)

3D structure

• AlphaFold DB: Q5M6C4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX	Streptococcus thermophilus LMD-9	100	100	1
comX	Streptococcus thermophilus LMG 18311	100	100	1
comX/sigX	Streptococcus salivarius strain HSISS4	89.091	100	0.891
comX	Streptococcus salivarius SK126	88.485	100	0.885
comX	Streptococcus sobrinus strain NIDR 6715-7	41.975	98.182	0.412
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	41.667	94.545	0.394
comX/sigX	Streptococcus mutans UA159	41.026	94.545	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX	Streptococcus suis D9	40.523	92.727	0.376
comX/sigX	Streptococcus suis isolate S10	40.523	92.727	0.376
comX/sigX	Streptococcus suis P1/7	40.523	92.727	0.376