Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA   Type   Machinery gene
Locus tag   DK181_RS00910 Genome accession   NZ_CP029490
Coordinates   153729..154676 (+) Length   315 a.a.
NCBI ID   WP_002959503.1    Uniprot ID   A0ABM6W3S4
Organism   Streptococcus sobrinus strain SL1     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 148729..159676
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK181_RS00895 (DK182_00895) - 149608..149970 (-) 363 WP_002959493.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  DK181_RS00900 (DK182_00900) - 150331..152715 (-) 2385 WP_019771344.1 HAD-IC family P-type ATPase -
  DK181_RS00905 (DK182_00905) - 152935..153303 (+) 369 WP_019781971.1 DUF1033 family protein -
  DK181_RS00910 (DK182_00910) comGA/cglA 153729..154676 (+) 948 WP_002959503.1 competence type IV pilus ATPase ComGA Machinery gene
  DK181_RS00915 (DK182_00915) comGB 154600..155643 (+) 1044 WP_002959504.1 competence type IV pilus assembly protein ComGB Machinery gene
  DK181_RS00920 (DK182_00920) comGC 155640..155966 (+) 327 WP_019770073.1 competence type IV pilus major pilin ComGC Machinery gene
  DK181_RS00925 (DK182_00925) comGD 155920..156354 (+) 435 WP_254051091.1 competence type IV pilus minor pilin ComGD Machinery gene
  DK181_RS00930 (DK182_00930) comGE 156326..156619 (+) 294 WP_002959510.1 competence type IV pilus minor pilin ComGE Machinery gene
  DK181_RS00935 (DK182_00935) comGF 156603..157040 (+) 438 WP_002959513.1 competence type IV pilus minor pilin ComGF Machinery gene
  DK181_RS00940 (DK182_00940) comGG 157018..157479 (+) 462 WP_002959515.1 competence type IV pilus minor pilin ComGG Machinery gene
  DK181_RS00950 (DK182_00950) - 157681..157947 (+) 267 WP_002959516.1 type II toxin-antitoxin system RelE/ParE family toxin -
  DK181_RS00955 (DK182_00955) - 157934..158209 (+) 276 WP_002959518.1 helix-turn-helix domain-containing protein -
  DK181_RS00960 (DK182_00960) comGH 158308..159261 (+) 954 WP_019771347.1 class I SAM-dependent methyltransferase Machinery gene

Sequence

Protein


Download         Length: 315 a.a.        Molecular weight: 35348.71 Da        Isoelectric Point: 6.3082

>NTDB_id=253701 DK181_RS00910 WP_002959503.1 153729..154676(+) (comGA/cglA) [Streptococcus sobrinus strain SL1]
MVEVQELGKELIRQAVEEQAQDIYLLPKLAVYKIYLRFGEKRHLIQTCPPEQAAGLISHFKFLAGMNVGEKRRAQLGACD
YAFADGETAALRLSTVGDYQGRESLVIRLLFDRKRELKFWFDGLNALLPKIIGRGLYLFSGPVGSGKTTLMYELVSRKYP
DSQIITIEDPVEIKQDNMLQLQLNPSIGMTYDHLIKLSLRHRPDVLIIGEIRDRETAQAVIRASLTGIRVFSTVHAKSIP
GVYARILELGVSQDELDNCLAGIAYQRLIGGGGLIDFAQDHFQNHQAECWNEKIDQLLAAGHLTEEEAAAEKIKD

Nucleotide


Download         Length: 948 bp        

>NTDB_id=253701 DK181_RS00910 WP_002959503.1 153729..154676(+) (comGA/cglA) [Streptococcus sobrinus strain SL1]
ATGGTTGAAGTGCAGGAGCTGGGAAAGGAATTGATTAGACAGGCAGTTGAGGAGCAGGCTCAGGATATTTATCTTTTGCC
CAAGCTGGCTGTTTATAAGATTTATCTACGGTTTGGCGAGAAGCGGCACTTGATTCAGACTTGCCCTCCCGAGCAGGCTG
CGGGTCTGATTAGTCACTTTAAATTTCTTGCTGGCATGAATGTTGGTGAGAAGCGACGGGCCCAGCTGGGTGCCTGTGAT
TATGCCTTCGCTGATGGTGAGACAGCGGCCTTGCGTTTATCGACGGTTGGCGACTATCAAGGGCGAGAAAGTCTGGTTAT
TCGCCTGCTCTTTGACAGAAAACGAGAGTTGAAATTTTGGTTTGATGGTCTAAATGCCCTCCTGCCCAAGATTATCGGGC
GAGGCCTCTACCTTTTTTCTGGACCTGTCGGGTCGGGCAAGACGACCCTCATGTATGAACTGGTCAGTCGCAAGTACCCA
GACAGTCAGATTATTACCATTGAGGATCCTGTTGAGATTAAGCAGGATAATATGCTCCAACTCCAGCTTAATCCCTCTAT
CGGGATGACCTATGACCATTTGATTAAGCTCTCCCTGCGCCATCGGCCGGATGTTCTAATTATCGGAGAAATTCGCGATA
GGGAGACCGCCCAAGCAGTTATTAGGGCTAGCCTAACAGGGATCCGAGTTTTTTCGACTGTTCATGCCAAGAGTATTCCA
GGGGTCTACGCCCGGATTTTAGAGCTGGGTGTTAGCCAGGATGAGTTAGATAATTGTCTGGCCGGCATTGCCTACCAGCG
TTTAATTGGGGGAGGAGGATTGATTGATTTTGCCCAAGACCATTTTCAAAACCACCAGGCTGAGTGCTGGAATGAAAAAA
TTGACCAACTTCTTGCAGCAGGACATCTCACTGAGGAAGAGGCGGCCGCCGAAAAAATTAAAGACTAG

Domains

Predicted by InterProScan.

Type II/IV secretion system protein (T2SSE)

(11-269)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

99.683

100

0.997
  comGA Streptococcus mutans UA140

66.026

99.048

0.654
  comGA Streptococcus mutans UA159

66.026

99.048

0.654
  comGA Streptococcus gordonii str. Challis substr. CH1

65.705

99.048

0.651
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

62.903

98.413

0.619
  comGA/cglA/cilD Streptococcus pneumoniae D39

62.903

98.413

0.619
  comGA/cglA/cilD Streptococcus pneumoniae R6

62.903

98.413

0.619
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

62.903

98.413

0.619
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

62.581

98.413

0.616
  comGA Lactococcus lactis subsp. cremoris KW2

56.129

98.413

0.552