Detailed information NTG0247899

Bioinformatically predicted

Overview

• Name: comGC/cglC
• Type: Machinery gene
• Locus tag: CO686_RS10195
• Genome accession: NZ_CP023507
• Coordinates: 2048600..2048923 (+)
• Length: 107 a.a.
• NCBI ID: WP_000735800.1
• Uniprot ID: A0A0F2DUU0
• Organism: Streptococcus oralis strain FDAARGOS_367
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2043600..2053923

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CO686_RS10175 (CO686_10175)	nagA	2044959..2046110 (+)	1152	WP_001134442.1	N-acetylglucosamine-6-phosphate deacetylase	-
CO686_RS10180 (CO686_10180)	-	2046263..2046628 (+)	366	WP_000286399.1	DUF1033 family protein	-
CO686_RS10185 (CO686_10185)	comGA/cglA/cilD	2046693..2047634 (+)	942	WP_096753791.1	competence type IV pilus ATPase ComGA	Machinery gene
CO686_RS10190 (CO686_10190)	comGB/cglB	2047582..2048598 (+)	1017	WP_096753792.1	competence type IV pilus assembly protein ComGB	Machinery gene
CO686_RS10195 (CO686_10195)	comGC/cglC	2048600..2048923 (+)	324	WP_000735800.1	competence type IV pilus major pilin ComGC	Machinery gene
CO686_RS10200 (CO686_10200)	comGD/cglD	2048886..2049320 (+)	435	WP_172844179.1	competence type IV pilus minor pilin ComGD	Machinery gene
CO686_RS10205 (CO686_10205)	comGE/cglE	2049283..2049585 (+)	303	WP_000413383.1	competence type IV pilus minor pilin ComGE	Machinery gene
CO686_RS10210 (CO686_10210)	comGF/cglF	2049548..2050009 (+)	462	WP_000250700.1	competence type IV pilus minor pilin ComGF	Machinery gene
CO686_RS10215 (CO686_10215)	comGG/cglG	2049987..2050400 (+)	414	WP_000265645.1	competence type IV pilus minor pilin ComGG	Machinery gene
CO686_RS10220 (CO686_10220)	-	2050433..2051023 (+)	591	WP_000679770.1	class I SAM-dependent methyltransferase	-
CO686_RS10225 (CO686_10225)	comYH	2051082..2052035 (+)	954	WP_000345140.1	class I SAM-dependent methyltransferase	Machinery gene

Sequence

Protein

• Length: 107 a.a.
• Molecular weight: 11835.95 Da
• Isoelectric Point: 10.0527

>NTDB_id=247899 CO686_RS10195 WP_000735800.1 2048600..2048923(+) (comGC/cglC) [Streptococcus oralis strain FDAARGOS_367]
MKKLMTNLKKAKVKAFTLVEMLVVLLIISVLLLLFVPNLTKQKDAVDDKGKAAVVKVVESQAELYSLDKNEDASLSKLQA
DGRITAEQAKAYKDYHAKQKTSQTVAD

Nucleotide

• Length: 324 bp

>NTDB_id=247899 CO686_RS10195 WP_000735800.1 2048600..2048923(+) (comGC/cglC) [Streptococcus oralis strain FDAARGOS_367]
GTGAAAAAACTCATGACAAATTTAAAAAAAGCCAAGGTTAAAGCTTTCACTTTGGTAGAGATGCTAGTGGTCTTGCTCAT
CATCAGTGTTCTTCTCTTGCTCTTTGTGCCCAATTTGACCAAGCAAAAGGATGCCGTAGATGATAAAGGAAAAGCTGCTG
TTGTCAAGGTCGTAGAAAGCCAGGCAGAGCTCTATAGTCTGGACAAGAATGAAGATGCTAGCCTTAGCAAATTACAAGCG
GACGGCCGTATCACAGCTGAGCAAGCTAAAGCTTATAAAGACTACCATGCAAAACAAAAAACAAGTCAAACTGTTGCAGA
TTAA

Domains

Predicted by InterproScan.

• Prokaryotic N-terminal methylation motif (N_methyl) (11-34)

3D structure

• AlphaFold DB: A0A0F2DUU0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGC/cglC	Streptococcus mitis NCTC 12261	93.458	100	0.935
comGC/cglC	Streptococcus mitis SK321	90.909	92.523	0.841
comGC/cglC	Streptococcus pneumoniae R6	88.889	92.523	0.822
comGC/cglC	Streptococcus pneumoniae Rx1	88.889	92.523	0.822
comGC/cglC	Streptococcus pneumoniae D39	88.889	92.523	0.822
comGC/cglC	Streptococcus pneumoniae TIGR4	87.879	92.523	0.813
comYC	Streptococcus gordonii str. Challis substr. CH1	67.619	98.131	0.664
comYC	Streptococcus mutans UA140	69.072	90.654	0.626
comYC	Streptococcus mutans UA159	69.072	90.654	0.626
comYC	Streptococcus suis isolate S10	67.045	82.243	0.551
comGC	Lactococcus lactis subsp. cremoris KW2	56.436	94.393	0.533