Detailed information NTG0218439

Bioinformatically predicted

Overview

• Name: comX
• Type: Regulator
• Locus tag: CR921_RS00850
• Genome accession: NZ_CP025399
• Coordinates: 143562..144059 (+)
• Length: 165 a.a.
• NCBI ID: WP_002949220.1
• Uniprot ID: Q5M6C4
• Organism: Streptococcus thermophilus strain GABA
• Function: activation of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 138562..149059

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CR921_RS00825	-	139936..140258 (-)	323	Protein_109	transposase	-
CR921_RS00830	-	140447..140791 (+)	345	WP_023909336.1	aminoacylase	-
CR921_RS00835	-	140894..142084 (+)	1191	WP_084825614.1	SAM-dependent methyltransferase	-
CR921_RS00840	-	142344..142808 (-)	465	Protein_112	transposase family protein	-
CR921_RS00845	-	143166..143270 (+)	105	Protein_113	IS200/IS605 family transposase	-
CR921_RS00850	comX	143562..144059 (+)	498	WP_002949220.1	sigma factor	Regulator
CR921_RS00855	-	144159..145001 (-)	843	WP_023909339.1	mechanosensitive ion channel family protein	-
CR921_RS00860	tig	145142..146425 (+)	1284	WP_011680653.1	trigger factor	-
CR921_RS00865	rpoE	146583..147158 (+)	576	WP_002949228.1	DNA-directed RNA polymerase subunit delta	-
CR921_RS00870	-	147409..149013 (+)	1605	WP_002949230.1	CTP synthase	-

Sequence

Protein

• Length: 165 a.a.
• Molecular weight: 20160.12 Da
• Isoelectric Point: 5.2073

>NTDB_id=218439 CR921_RS00850 WP_002949220.1 143562..144059(+) (comX) [Streptococcus thermophilus strain GABA]
MEQEVFVKAYEKVRPIVLKAFRQYFIQLWDQADMEQEAMMTLYQLLKKFPDLEKDDDKLRRYFKTKFRNRLNDEVRRQES
VKRQANRQCYVEISDIAFCIPNKELDMVDRLAYDEQLNAFREQLSSEDSLKLDRLLGGECFRGRKKMIRELRFWMVDFDP
CNEED

Nucleotide

• Length: 498 bp

>NTDB_id=218439 CR921_RS00850 WP_002949220.1 143562..144059(+) (comX) [Streptococcus thermophilus strain GABA]
ATGGAACAAGAAGTTTTTGTTAAGGCATATGAAAAGGTAAGGCCAATTGTACTTAAGGCTTTTAGGCAATACTTTATTCA
GCTTTGGGATCAAGCTGACATGGAGCAAGAGGCGATGATGACTTTGTATCAGCTTTTAAAAAAGTTTCCTGATTTAGAGA
AAGATGATGATAAGTTACGTCGTTACTTTAAAACTAAGTTTAGGAATCGACTTAATGATGAAGTGAGGCGGCAGGAGTCA
GTAAAACGTCAAGCTAATAGACAGTGCTATGTTGAAATTTCAGATATTGCCTTTTGTATTCCCAATAAGGAGCTAGATAT
GGTTGATAGACTTGCTTATGATGAACAGCTTAATGCTTTTCGTGAGCAGTTATCATCGGAAGATTCTCTTAAGTTGGATC
GATTGTTGGGTGGTGAATGCTTTAGGGGAAGGAAAAAGATGATACGAGAGTTAAGATTTTGGATGGTTGACTTTGATCCA
TGTAATGAAGAAGACTGA

Domains

Predicted by InterProScan.

• Sigma-70 region 2 (Sigma70_r2) (10-79)

3D structure

• AlphaFold DB: Q5M6C4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX	Streptococcus thermophilus LMD-9	100	100	1
comX	Streptococcus thermophilus LMG 18311	100	100	1
comX/sigX	Streptococcus salivarius strain HSISS4	89.091	100	0.891
comX	Streptococcus salivarius SK126	88.485	100	0.885
comX	Streptococcus sobrinus strain NIDR 6715-7	41.975	98.182	0.412
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	41.667	94.545	0.394
comX/sigX	Streptococcus mutans UA159	41.026	94.545	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX	Streptococcus suis D9	40.523	92.727	0.376
comX/sigX	Streptococcus suis isolate S10	40.523	92.727	0.376
comX/sigX	Streptococcus suis P1/7	40.523	92.727	0.376