Detailed information NTG0216289

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: BWR56_RS00040
• Genome accession: NZ_CP019562
• Coordinates: 6000..6752 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866079.1
• Uniprot ID: A0A081R422
• Organism: Streptococcus oralis strain S.MIT/ORALIS-351
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1000..11752

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BWR56_RS00010 (BWR56_0002)	spo0J	1579..2337 (-)	759	WP_049505012.1	ParB/RepB/Spo0J family partition protein	Regulator
BWR56_RS00015 (BWR56_0003)	htrA	2395..3591 (-)	1197	WP_049505014.1	S1C family serine protease	Regulator
BWR56_RS00020 (BWR56_0004)	rlmH	3777..4256 (+)	480	WP_049505015.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
BWR56_RS00030 (BWR56_0006)	comC/comC1	4538..4663 (+)	126	WP_008282505.1	competence-stimulating peptide ComC	Regulator
BWR56_RS00035 (BWR56_0007)	comD	4684..6003 (+)	1320	WP_049505018.1	competence system sensor histidine kinase ComD	Regulator
BWR56_RS00040 (BWR56_0008)	comE	6000..6752 (+)	753	WP_000866079.1	competence system response regulator transcription factor ComE	Regulator
BWR56_RS00055 (BWR56_0011)	-	6990..7532 (-)	543	WP_049477913.1	TetR/AcrR family transcriptional regulator	-
BWR56_RS00060 (BWR56_0012)	-	7661..10315 (+)	2655	WP_076984213.1	YhgE/Pip domain-containing protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29884.23 Da
• Isoelectric Point: 6.9755

>NTDB_id=216289 BWR56_RS00040 WP_000866079.1 6000..6752(+) (comE) [Streptococcus oralis strain S.MIT/ORALIS-351]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=216289 BWR56_RS00040 WP_000866079.1 6000..6752(+) (comE) [Streptococcus oralis strain S.MIT/ORALIS-351]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCGGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAATTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATTGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACGTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAAGATATCAATGATGAATTGTTCAAAAAACGCATCGAGCAGAGTATTTTTTACACTAAGAGTATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCTAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTAGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGTCCCATTACCCGTTTGAAAGTTCGTAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081R422

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.6	100	0.956
comE	Streptococcus mitis SK321	94.8	100	0.948
comE	Streptococcus pneumoniae Rx1	94	100	0.94
comE	Streptococcus pneumoniae D39	94	100	0.94
comE	Streptococcus pneumoniae R6	94	100	0.94
comE	Streptococcus pneumoniae TIGR4	94	100	0.94
comE	Streptococcus infantis strain Atu-4	93.6	100	0.936
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4