Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   BWR56_RS00035 Genome accession   NZ_CP019562
Coordinates   4684..6003 (+) Length   439 a.a.
NCBI ID   WP_049505018.1    Uniprot ID   -
Organism   Streptococcus oralis strain S.MIT/ORALIS-351     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1..11003
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BWR56_RS00005 (BWR56_0001) dnaA 1..1362 (-) 1362 WP_061421574.1 chromosomal replication initiator protein DnaA -
  BWR56_RS00010 (BWR56_0002) spo0J 1579..2337 (-) 759 WP_049505012.1 ParB/RepB/Spo0J family partition protein Regulator
  BWR56_RS00015 (BWR56_0003) htrA 2395..3591 (-) 1197 WP_049505014.1 S1C family serine protease Regulator
  BWR56_RS00020 (BWR56_0004) rlmH 3777..4256 (+) 480 WP_049505015.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  BWR56_RS00030 (BWR56_0006) comC/comC1 4538..4663 (+) 126 WP_008282505.1 competence-stimulating peptide ComC Regulator
  BWR56_RS00035 (BWR56_0007) comD 4684..6003 (+) 1320 WP_049505018.1 competence system sensor histidine kinase ComD Regulator
  BWR56_RS00040 (BWR56_0008) comE 6000..6752 (+) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  BWR56_RS00055 (BWR56_0011) - 6990..7532 (-) 543 WP_049477913.1 TetR/AcrR family transcriptional regulator -
  BWR56_RS00060 (BWR56_0012) - 7661..10315 (+) 2655 WP_076984213.1 YhgE/Pip domain-containing protein -

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 50928.87 Da        Isoelectric Point: 6.5044

>NTDB_id=216288 BWR56_RS00035 WP_049505018.1 4684..6003(+) (comD) [Streptococcus oralis strain S.MIT/ORALIS-351]
MSLLGFGIVILHIFILTISYELICKVTKKERYLFIACIFVYQSVAEFFFDFISLGGLGIEKFIFPFILYTSIVVLKKYDK
HKGMFISLLLSLLYHSTHTFLSVTLSSITGDAFVIEHEVMFYLGVLLLTYLIIKKIITYFHLELTYFDKDYLYPFLKKVI
VAFFGLHILLFISDIVSTTHHLNSFGSILSTIVFICLLLIFFAMNSHKVQIEKEIALKQKKFEQKHLQTYTDEIVELYNE
IRGFRHDYAGMLVSMQMAIDSGDLQEINRVYNEVLVKANQKLRSEKYTYFDLNNIEDSALRSLIAQSIVYARKNDVEFTL
EVKDIITRLSIDLLDLVRIMSILLNNAVEGAADSYLKQMEVAVIKMDFETVIVIQNSCKITMTPSEDLFALGFSTKGRNR
GLGLNNVKEILDKYDNIILETEMEDNTFRQIIRFKREFE

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=216288 BWR56_RS00035 WP_049505018.1 4684..6003(+) (comD) [Streptococcus oralis strain S.MIT/ORALIS-351]
ATGAGTTTATTAGGATTTGGGATAGTTATTCTTCATATTTTTATTTTAACAATAAGCTATGAATTAATTTGTAAAGTAAC
TAAAAAAGAAAGATATTTATTTATAGCTTGTATATTTGTATATCAGTCTGTAGCTGAATTTTTCTTTGACTTTATTTCAT
TAGGTGGGTTAGGGATTGAAAAGTTTATATTTCCTTTTATTCTATATACTTCTATAGTAGTTTTAAAGAAATATGATAAG
CATAAAGGAATGTTTATCAGTTTACTATTGTCTTTATTATATCACAGTACACATACTTTTTTATCAGTAACCCTATCCTC
TATAACAGGTGATGCTTTTGTGATAGAACATGAAGTGATGTTTTATTTAGGAGTACTATTACTAACATATTTAATTATTA
AAAAAATTATTACTTATTTCCATTTAGAACTTACTTATTTTGATAAAGATTATCTGTACCCTTTTTTAAAAAAAGTAATA
GTTGCTTTCTTTGGTTTGCATATCTTATTGTTTATTTCAGATATAGTAAGTACAACTCATCATTTAAATAGCTTCGGAAG
TATTTTATCAACCATTGTTTTTATTTGCTTGTTATTGATTTTCTTTGCAATGAATTCTCACAAGGTTCAAATTGAAAAAG
AGATTGCTCTAAAACAAAAGAAATTTGAACAAAAACATTTACAGACTTATACTGATGAAATTGTGGAGTTGTATAATGAA
ATTCGAGGTTTTCGTCATGACTATGCAGGGATGCTTGTTAGCATGCAAATGGCGATTGACAGTGGAGATTTACAAGAAAT
TAACAGGGTTTACAATGAAGTCCTAGTAAAAGCAAATCAGAAATTGAGGTCAGAAAAATATACTTACTTTGATTTAAATA
ATATAGAAGACTCTGCTTTACGGAGTTTAATTGCTCAATCGATTGTCTATGCACGAAAAAATGATGTAGAGTTTACATTG
GAAGTAAAGGATATCATTACTAGACTGTCAATAGATTTACTTGATCTGGTTCGTATCATGAGCATTTTATTAAACAATGC
CGTTGAAGGTGCTGCAGATAGTTATTTGAAACAAATGGAAGTTGCAGTCATTAAAATGGATTTTGAAACAGTTATAGTTA
TCCAGAATTCATGCAAAATCACTATGACGCCTTCAGAGGATCTATTTGCCTTAGGTTTCTCTACCAAGGGAAGAAATAGA
GGTCTAGGGCTTAATAATGTCAAAGAGATCTTAGATAAGTATGACAACATTATCTTAGAAACTGAGATGGAAGACAACAC
ATTTAGACAAATTATTAGATTTAAGAGGGAATTCGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(333-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis NCTC 12261

75.737

100

0.761
  comD/comD2 Streptococcus pneumoniae TIGR4

74.376

100

0.747
  comD Streptococcus mitis SK321

74.376

100

0.747
  comD/comD1 Streptococcus pneumoniae Rx1

73.696

100

0.74
  comD/comD1 Streptococcus pneumoniae D39

73.696

100

0.74
  comD/comD1 Streptococcus pneumoniae R6

73.696

100

0.74
  comD/comD2 Streptococcus gordonii strain NCTC7865

50.532

85.649

0.433
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

50

85.194

0.426

Multiple sequence alignment