Detailed information    

insolico Bioinformatically predicted

Overview


Name   comC/comC1   Type   Regulator
Locus tag   BWR56_RS00030 Genome accession   NZ_CP019562
Coordinates   4538..4663 (+) Length   41 a.a.
NCBI ID   WP_008282505.1    Uniprot ID   A0A139Q4L7
Organism   Streptococcus oralis strain S.MIT/ORALIS-351     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context


Location: 1..9663
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BWR56_RS00005 (BWR56_0001) dnaA 1..1362 (-) 1362 WP_061421574.1 chromosomal replication initiator protein DnaA -
  BWR56_RS00010 (BWR56_0002) spo0J 1579..2337 (-) 759 WP_049505012.1 ParB/RepB/Spo0J family partition protein Regulator
  BWR56_RS00015 (BWR56_0003) htrA 2395..3591 (-) 1197 WP_049505014.1 S1C family serine protease Regulator
  BWR56_RS00020 (BWR56_0004) rlmH 3777..4256 (+) 480 WP_049505015.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  BWR56_RS00030 (BWR56_0006) comC/comC1 4538..4663 (+) 126 WP_008282505.1 competence-stimulating peptide ComC Regulator
  BWR56_RS00035 (BWR56_0007) comD 4684..6003 (+) 1320 WP_049505018.1 competence system sensor histidine kinase ComD Regulator
  BWR56_RS00040 (BWR56_0008) comE 6000..6752 (+) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  BWR56_RS00055 (BWR56_0011) - 6990..7532 (-) 543 WP_049477913.1 TetR/AcrR family transcriptional regulator -

Sequence


Protein


Download         Length: 41 a.a.        Molecular weight: 4957.73 Da        Isoelectric Point: 10.2767

>NTDB_id=216287 BWR56_RS00030 WP_008282505.1 4538..4663(+) (comC/comC1) [Streptococcus oralis strain S.MIT/ORALIS-351]
MKNTVKLEQFKEVTEAELQEIRGGDKRLPYFFKHLFSNRTK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=216287 BWR56_RS00030 WP_008282505.1 4538..4663(+) (comC/comC1) [Streptococcus oralis strain S.MIT/ORALIS-351]
ATGAAAAATACAGTAAAGTTGGAACAATTTAAAGAAGTAACAGAGGCAGAATTGCAGGAGATTCGAGGTGGAGATAAAAG
ACTACCTTACTTTTTTAAACATCTTTTTTCAAATAGGACAAAGTAG

Domains


Predicted by InterproScan.

(1-31)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A139Q4L7

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC1 Streptococcus pneumoniae R6

53.659

100

0.537

  comC/comC1 Streptococcus pneumoniae G54

53.659

100

0.537

  comC/comC1 Streptococcus pneumoniae D39

53.659

100

0.537

  comC/comC1 Streptococcus pneumoniae Rx1

53.659

100

0.537

  comC Streptococcus mitis SK321

68.966

70.732

0.488

  comC/comC2 Streptococcus pneumoniae A66

58.621

70.732

0.415

  comC/comC2 Streptococcus pneumoniae TIGR4

58.621

70.732

0.415

  comC Streptococcus mitis NCTC 12261

55.556

65.854

0.366

  comC/blpC Streptococcus mutans UA159

44.118

82.927

0.366


Multiple sequence alignment